Preparation method of absorbable biological film

A biofilm and copolymer technology, applied in the medical and health field, can solve problems such as difficult organ repair, life-threatening, bleeding, etc., and achieve good biocompatibility, optimized mechanical properties, and simple operation

Inactive Publication Date: 2018-08-28
SUZHOU ORIZA MEDICAL INSTR CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to these anatomical, physiological and pathological characteristics, it is difficult to repair the viscera, and the viscera has to be partially removed or even completely removed during the operation. Some postoperative bleeding, intestinal flaccidity, adhesive intestinal obstruction, and even life-threatening

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The absorbable biofilm of this embodiment includes the following raw materials in parts by weight: 50 parts by weight of polylactide, 100 parts by weight of gelatin, 120 parts by weight of polylactic acid-glycolic acid copolymer, and 30 parts by weight of aloin. The thickness of the absorbable biofilm is 2mm.

[0023] Its preparation method is as follows:

[0024] (1) Take the polylactide, gelatin, polylactic acid-glycolic acid copolymer, and aloin in parts by weight, add to water, heat the mixed solution to 60°C, add plasticizer glycerin, stir evenly, and Spinning solution was obtained after degassing for 0.5h in the environment of -0.05Mpa;

[0025] (2) Put the spinning solution described in step (1) into an electrospinning device with a temperature of 60°C, use hot air as the medium, and the air velocity is 0.5m / min, and adjust the feeding rate of the solution to 100ul / min, the distance between the spinneret and the collector is 10cm, under the voltage of 20kv, th...

Embodiment 2

[0027] The absorbable biofilm of this embodiment includes the following raw materials in parts by weight: 100 parts by weight of polylactide, 65 parts by weight of gelatin, 100 parts by weight of polylactic acid-glycolic acid copolymer, and 80 parts by weight of aloin. The thickness of the absorbable biofilm is 5mm.

[0028] Its preparation method is as follows:

[0029] (1) Take the polylactide, gelatin, polylactic acid-glycolic acid copolymer, and aloin in parts by weight, add to water, heat the mixed solution to 80°C, add plasticizer glycerin, stir evenly, and Spinning solution was obtained after degassing in the environment of -0.1Mpa for 2 hours;

[0030] (2) Put the spinning solution described in step (1) into an electrospinning device with a temperature of 60°C, use hot air as the medium, and the air velocity is 1.5m / min, and adjust the feeding rate of the solution to 50ul / min, the distance between the spinneret and the collector is 20cm, under the voltage of 25kv, t...

Embodiment 3

[0032] The absorbable biofilm of this embodiment includes the following raw materials in parts by weight: 75 parts by weight of polylactide, 30 parts by weight of gelatin, 150 parts by weight of polylactic acid-glycolic acid copolymer, and 55 parts by weight of aloin. The thickness of the absorbable biofilm is 0.8mm.

[0033] Its preparation method is as follows:

[0034] (1) Take the polylactide, gelatin, polylactic acid-glycolic acid copolymer, and aloin in parts by weight, add to water, heat the mixed solution to 60°C, add plasticizer glycerin, stir evenly, and Spinning solution was obtained after degassing in the environment of -0.1Mpa for 2 hours;

[0035] (2) Put the spinning solution described in step (1) into an electrospinning device with a temperature of 50°C, use hot air as the medium, and the air velocity is 0.5m / min, and adjust the feeding rate of the solution to 50ul / min, the distance between the spinneret and the collector is 20cm, under the voltage of 25kv, ...

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Abstract

The invention provides a preparation method of an absorbable biological film. The biological film is prepared by adopting an electrostatic spinning technology, so that the operation is simple, and conditions are easy to control. In a spinning process, a plasticizer is added, so that the mechanical property of the absorbable biological film is optimized. Adopted raw materials are biologically absorbable macromolecules, so that the absorbable biological film is high in biocompatibility and can be biologically decomposed and absorbed, and no foreign matters are retained; furthermore, the tensilestrength is improved, and the flexibility of the biological film is improved.

Description

technical field [0001] The invention relates to the medical and health field, in particular to a method for preparing an absorbable biofilm. Background technique [0002] Substantial organs in the abdominal cavity, such as the liver, spleen, and kidneys, have rich blood circulation, thin capsules, and fragile tissues. Trauma and surgical hemostasis and repair are difficult. The viscera in the cavity of the gastrointestinal tract has a peristaltic function, and there is liquid and gas in the cavity. When peritonitis occurs or after surgery, intestinal peristalsis is weakened, a large amount of liquid and gas are retained in the cavity, and the pressure increases, resulting in relatively thinning of the gastrointestinal wall. Increased tension, inflammatory edema, and fragile tissues. Due to these anatomical, physiological and pathological characteristics, it is difficult to repair the viscera. During the operation, the viscera has to be partially removed, or even completely ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/14A61L31/06A61L31/04A61L31/16D04H1/728D01D5/00
CPCA61L31/045A61L31/06A61L31/14A61L31/148A61L31/16A61L2300/216A61L2300/404D01D5/0015D04H1/728C08L67/04
Inventor 吴鸿
Owner SUZHOU ORIZA MEDICAL INSTR CO LTD
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