Preparation method of starch-based hard capsule

A starch-based and hard-based technology, which is applied in the field of starch-based hard capsule preparation, can solve problems such as difficulty in making strong hollow capsules, high viscosity of starch solution, and friable and brittle starch film, so as to reduce viscosity, improve mechanical properties, show smooth effect

Active Publication Date: 2018-09-07
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Starch is plant-derived, with a wide range of sources and very low price. It has good film-forming properties, and it is very attractive to prepare hollow capsules with it. However, because starch molecules are easy to form strong hydrogen bonds, the preparation of starch films is fragile. Brittle,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The present embodiment provides a kind of preparation method of starch-based hard capsule, comprises the steps:

[0029] 1. Accurately weigh a certain amount of cornstarch, put it in a stainless steel blending container, use a hydrochloric acid solution with a concentration of 0.14mol / L to prepare the starch into starch milk with a starch content of 40%, and place it in a constant temperature shaking incubator at 35°C and 200rpm Acid hydrolysis in 11h. After the acid hydrolysis, the pH value of the starch milk was adjusted to 5.5 with 5% NaOH solution. First use a centrifuge to discard the supernatant, then centrifuge and wash with twice the volume of distilled water for 3 times, set the centrifuge speed to 5000r / min, and centrifuge for 10min, then react in an oven (40-45°C) for 10h , to get acid-thinned starch.

[0030] 2. Take the acid-thinned starch obtained in step 1, make starch milk with a starch content of 20% with distilled water, pour it into a stainless stee...

Embodiment 2

[0033] The present embodiment provides a kind of preparation method of starch-based hard capsule, comprises the steps:

[0034] 1. Accurately weigh a certain amount of cornstarch, place it in a stainless steel blending container, use a hydrochloric acid solution with a concentration of 0.14mol / L to prepare the starch into starch milk with a starch content of 40%, and place it in a constant temperature shaking incubator at 37°C and 200rpm Acid hydrolysis in 18h. After the acid hydrolysis, the pH value of the starch milk was adjusted to 5.5 with 5% NaOH solution. First use a centrifuge to discard the supernatant, then centrifuge and wash with twice the volume of distilled water for 3 times, set the centrifuge speed to 5000r / min, and centrifuge for 10min, then react in an oven (40-45°C) for 11h , to get acid-thinned starch.

[0035]2. Take the acid-thinned starch obtained in step 1, make starch milk with a starch content of 20% with distilled water, pour it into a stainless ste...

Embodiment 3

[0038] The present embodiment provides a kind of preparation method of starch-based hard capsule, comprises the steps:

[0039] 1. Accurately weigh a certain amount of corn starch, put it in a stainless steel blending container, use a hydrochloric acid solution with a concentration of 0.14mol / L to prepare the starch into starch milk with a starch content of 40%, and place it in a constant temperature shaking incubator at 40°C and 200rpm Acid hydrolysis in 12h. After the acid hydrolysis, the pH value of the starch milk was adjusted to 5.5 with 5% NaOH solution. First use a centrifuge to discard the supernatant, then centrifuge and wash with twice the volume of distilled water for 3 times, set the centrifuge speed to 5000r / min, and centrifuge for 10min, then react in an oven (40-45°C) for 12h , to get acid-thinned starch.

[0040] 2. Take the acid-thinned starch obtained in step 1, make starch milk with a starch content of 20% with distilled water, pour it into a stainless ste...

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PUM

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Abstract

The invention belongs to the technical field of medicine preparation, and particularly discloses a preparation method of a starch-based hard capsule. The preparation method comprises the following steps of acid degradation of starch, etherification, solation, insulating, defoaming, glue dipping and forming, drying and the like. According to the preparation method disclosed by the invention, the starch is treated by acid degradation and etherification composite modification, and further the viscosity of the starch is reduced; meanwhile, the film forming property of the starch is improved; the starch-based hard capsule is prepared by adopting high-amylose starch with the amylase content of 80 percent as a matrix and the modified starch as a reinforced phase and using a traditional dipping forming process. The starch-based hard capsule prepared by the method disclosed by the invention has the advantages of high transparency, smooth surface, good bending resistance, short disintegration time limit and the like; a production process is also simplified; the preparation method is suitable for being popularized and applied on a large scale.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a method for preparing starch-based hard capsules. Background technique [0002] Capsules are generally used to package drugs that are not suitable for direct contact with the esophagus and need to be disintegrated in the stomach or intestinal tract. At present, most of the hard capsules of medicinal or health food are made of gelatin, and gelatin still has certain problems in terms of medicinal properties and safety. On the one hand, gelatin comes from animal skin or bone, which is treated with acid or alkali and boiled. In the production process, there will inevitably be animal protein residues, which are prone to cross-linking reactions with the drugs contained in them and have the risk of carrying viruses, which will lead to adverse consequences such as drug deterioration. On the other hand, animal-derived gelatin is unacceptable to vegetarians and those who ho...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/36C08B31/00C08B31/10A23P10/30A23L29/30A23L33/00
CPCA23L29/30A23L33/00A23P10/30A61K9/4816A61K47/36C08B31/00C08B31/10
Inventor 陈佩乔倩李远志
Owner SOUTH CHINA AGRI UNIV
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