Preparation method of starch-based hard capsule

Abstract

The invention belongs to the technical field of medicine preparation, and particularly discloses a preparation method of a starch-based hard capsule. The preparation method comprises the following steps of acid degradation of starch, etherification, solation, insulating, defoaming, glue dipping and forming, drying and the like. According to the preparation method disclosed by the invention, the starch is treated by acid degradation and etherification composite modification, and further the viscosity of the starch is reduced; meanwhile, the film forming property of the starch is improved; the starch-based hard capsule is prepared by adopting high-amylose starch with the amylase content of 80 percent as a matrix and the modified starch as a reinforced phase and using a traditional dipping forming process. The starch-based hard capsule prepared by the method disclosed by the invention has the advantages of high transparency, smooth surface, good bending resistance, short disintegration time limit and the like; a production process is also simplified; the preparation method is suitable for being popularized and applied on a large scale.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a method for preparing starch-based hard capsules. Background technique [0002] Capsules are generally used to package drugs that are not suitable for direct contact with the esophagus and need to be disintegrated in the stomach or intestinal tract. At present, most of the hard capsules of medicinal or health food are made of gelatin, and gelatin still has certain problems in terms of medicinal properties and safety. On the one hand, gelatin comes from animal skin or bone, which is treated with acid or alkali and boiled. In the production process, there will inevitably be animal protein residues, which are prone to cross-linking reactions with the drugs contained in them and have the risk of carrying viruses, which will lead to adverse consequences such as drug deterioration. On the other hand, animal-derived gelatin is unacceptable to vegetarians and those who ho...

AI Technical Summary

Problems solved by technology

[0003] Starch is plant-derived, with a wide range of sources and very low price. It has good film-forming properties, and it is very attractive to prepare hollow capsules with it. However, because starch molecules are easy to form strong hydrogen bonds, the preparation of starch films is fragile. Brittle, it is difficult to make hollow capsules with high strength and filling resistance

In the existing process of preparing starch hard capsules by traditional dipping and forming methods, the biggest difficulty is that the viscosity of the starch solution is too high and it is difficult to control the thickness