Polymeric hydrogel based on acyl hydrazone bond and preparation method thereof as well as skin tissue adhesive

A polymer hydrogel, acylhydrazone bond technology, applied in the field of skin tissue adhesives and polymer hydrogels, can solve the problems of low tissue bonding strength, complex composition and structure, poor biocompatibility, etc. , to achieve the effect of high mechanical strength

Inactive Publication Date: 2018-09-07
SUN YAT SEN UNIV
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Problems solved by technology

However, there are two important challenges in the current clinical product development: ①The above-mentioned hydrogel materials have too high or too low tissue adhesion strength, which is not conducive to their application; ②Improve the adhesion of polymer hydrogels. Intensity necessarily means an increase in the density of polar groups, but the increase in the density of most polar groups will cause discomfort or inflammation in patients with skin wounds
At present, there is no polymer hydrogel system, which not only has suitable bonding strength, but also can protect and care for wounds well.
[0004] On the other hand, the current application of polymer hydrogels in soft tissue repair has received extensive attention and research, but its composition and structure are complex, and there are also challenges such as mechanical strength, structure and comprehensive performance t

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  • Polymeric hydrogel based on acyl hydrazone bond and preparation method thereof as well as skin tissue adhesive
  • Polymeric hydrogel based on acyl hydrazone bond and preparation method thereof as well as skin tissue adhesive
  • Polymeric hydrogel based on acyl hydrazone bond and preparation method thereof as well as skin tissue adhesive

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preparation example Construction

[0039] The present invention also provides a method for preparing a polymer hydrogel based on an acylhydrazone bond, which includes:

[0040] Step 110, preparing hydrazide-modified hyaluronic acid HAHZ;

[0041] Step 112, at room temperature, mix hydrazide-modified hyaluronic acid HAHZ with polyethylene oxide-polyoxypropylene-polyoxyethylene and water solvent in a preset ratio;

[0042] Step 114, stirring evenly to obtain a pre-crosslinked gel;

[0043] In step 116, the pre-crosslinked gel gradually becomes an elastic water-swellable three-dimensional network product or hydrogel.

[0044] Wherein, in step 112, HAHZ and part of the water solvent can be mixed to obtain a mixture 1, and the triblock polymer can be mixed with a part of the water solvent to obtain a mixture 2, and then the mixture 1 and 2 can be mixed and stirred evenly to obtain a pre-crosslinked gel. Or directly mix HAHZ and triblock polymer with water solvent.

[0045] Normal temperature is mentioned in step ...

Embodiment 1

[0051] At room temperature, the hydrazide-modified HA (HAHZ) was dissolved in water to prepare a 10% HAHZ solution, and the aldehyde-modified polyethylene oxide (PEO)-polyoxypropylene (PPO)-polyoxyethylene ( PEO), also known as poloxamer (PFAH), is dissolved in water to form a 10% PFAH solution, and 10% HAHZ solution and 10% PFAH solution are mixed in a volume ratio of 9:1 to obtain a gel precursor The mixture gradually becomes a water-swellable three-dimensional network or hydrogel with certain elasticity.

Embodiment 2

[0053] At room temperature, dissolve the hydrazide-modified HA (HAHZ) in water to make a 10% HAHZ solution, and dissolve the aldehyde-modified poloxamer (PFAH) in water to make a 10% PFAH solution 10% HAHZ solution and 10% PFAH solution are mixed uniformly at a volume ratio of 8:2 to obtain a gel precursor solution, and the mixture gradually becomes a water-swellable three-dimensional network or hydrogel with certain elasticity.

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Abstract

The invention relates to the field of preparation of hydrogel and in particular relates to polymeric hydrogel based on an acyl hydrazone bond and a preparation method thereof as well as a skin tissueadhesive. The polymeric hydrogel based on the acyl hydrazone bond is prepared from the following raw materials: acylhydrazino modified hyaluronic acid HAHZ and polyethylene oxide-polypropylene oxide-polyethylene oxide; the substituted degree of acylhydrazino is 3 to 100 percent. The hydrogel, which is prepared by taking a dynamic covalent bond as a crosslinking point, can have relatively high mechanical strength and self-repairing performance. The acyl hydrazone bond does not strongly irritate wound tissues and the high-density acyl hydrazone bond means proper tissue interface bonding strength, so that the polymeric hydrogel is a material combining advantages of hydrogel dressing and a tissue adhesive.

Description

technical field [0001] The invention relates to the field of hydrogel preparation, in particular to a polymer hydrogel based on an acylhydrazone bond, a preparation method thereof and a skin tissue adhesive. Background technique [0002] Polymer hydrogel is a three-dimensional network formed by chemical or physical cross-linking of polymers, which has certain mechanical strength and elasticity. Both natural and synthetic polymers can be used in the preparation of hydrogels. The cross-linked structure of polymer hydrogel can include various covalent bonds, chain entanglements, hydrogen bonds, hydrophobic interactions, electrostatic interactions, supramolecular interactions and other physical interactions, as well as disulfide bonds, Schiff bases, etc. And specially designed cross-linking forms such as dynamic covalent bonds such as acylhydrazone bonds. [0003] As a soft and wet material, it is no longer rare for polymer hydrogels to be used in clinical medicine. For examp...

Claims

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Application Information

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IPC IPC(8): A61L24/00A61L24/04A61L24/08
CPCA61L24/0031A61L24/046A61L24/08C08L5/08C08L71/02
Inventor 李自伊李志勇陈永明刘利新
Owner SUN YAT SEN UNIV
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