Polymeric hydrogel based on acyl hydrazone bond and preparation method thereof as well as skin tissue adhesive

Abstract

The invention relates to the field of preparation of hydrogel and in particular relates to polymeric hydrogel based on an acyl hydrazone bond and a preparation method thereof as well as a skin tissueadhesive. The polymeric hydrogel based on the acyl hydrazone bond is prepared from the following raw materials: acylhydrazino modified hyaluronic acid HAHZ and polyethylene oxide-polypropylene oxide-polyethylene oxide; the substituted degree of acylhydrazino is 3 to 100 percent. The hydrogel, which is prepared by taking a dynamic covalent bond as a crosslinking point, can have relatively high mechanical strength and self-repairing performance. The acyl hydrazone bond does not strongly irritate wound tissues and the high-density acyl hydrazone bond means proper tissue interface bonding strength, so that the polymeric hydrogel is a material combining advantages of hydrogel dressing and a tissue adhesive.

Description

technical field [0001] The invention relates to the field of hydrogel preparation, in particular to a polymer hydrogel based on an acylhydrazone bond, a preparation method thereof and a skin tissue adhesive. Background technique [0002] Polymer hydrogel is a three-dimensional network formed by chemical or physical cross-linking of polymers, which has certain mechanical strength and elasticity. Both natural and synthetic polymers can be used in the preparation of hydrogels. The cross-linked structure of polymer hydrogel can include various covalent bonds, chain entanglements, hydrogen bonds, hydrophobic interactions, electrostatic interactions, supramolecular interactions and other physical interactions, as well as disulfide bonds, Schiff bases, etc. And specially designed cross-linking forms such as dynamic covalent bonds such as acylhydrazone bonds. [0003] As a soft and wet material, it is no longer rare for polymer hydrogels to be used in clinical medicine. For examp...

AI Technical Summary

Problems solved by technology

However, there are two important challenges in the current clinical product development: ①The above-mentioned hydrogel materials have too high or too low tissue adhesion strength, which is not conducive to their application; ②Improve the adhesion of polymer hydrogels. Intensity necessarily means an increase in the density of polar groups, but the increase in the density of most polar groups will cause discomfort or inflammation in patients with skin wounds

At present, there is no polymer hydrogel system, which not only has suitable bonding strength, but also can protect and care for wounds well.

[0004] On the other hand, the current application of polymer hydrogels in soft tissue repair has received extensive attention and research, but its composition and structure are complex, and there are also challenges such as mechanical strength, structure and comprehensive performance that cannot be unified and improved together, and need to be further improved : ① For hydrogels with physical interaction as cross-linking points, their strength is relatively weak, so multiple cross-linking mechanisms are often used to design hydrogels; but this will undoubtedly increase the complexity of the hydrogel, which is not conducive to its Clinical promotion and commercialization; ②For hydrogels constructed with covalent bonds as cross-linking points, they do not have self-healing and plasticity. The degree of cross-linking will lead to the low scale of the hydrogel network, which will affect the infiltration and migration of cells; ③In addition, the molecular weight of most polymer materials is too high, the degradation rate is too fast or too slow, uncontrollable, or their biocompatibility is not good. good, but also restricts its application in the medical field

Images