A kind of preparation method of moisturizing lipstick containing shikonin liposome
A production method and a technique for shikonin lipid are applied in the directions of skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., and can solve the problems of high extraction cost of natural pigments, difficulty in adding, affecting coloring effects, and the like, and improve the emulsification effect. , The effect of increased film strength and not easy to break demulsification
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Embodiment 1
[0049] Table 1.1
[0050]
[0051]
[0052] The steps for preparing the above-mentioned products are as follows:
[0053] (1) Preparation of shikonin liposomes: Weigh 2g of lecithin and 0.4g of cholesterol in a round bottom flask, add 500mL of petroleum ether, stir to dissolve, then add 0.4g of shikonin, and rotate under reduced pressure at 40°C Recover the organic solvent, form a uniform purple-red lipid film in the round bottom flask, then add 200mL PBS buffer solution (pH=7.4), stir and elute the lipid film for 1 hour, sonicate in a water bath at 25°C for 5 minutes, filter with a 0.45 μm microporous membrane, Stand still for 10 minutes, repeat ultrasonic and filter membrane filtration under the same conditions, use a spray dryer to spray dry the obtained product at an inlet temperature of 110°C, and obtain 1.2 g of shikonin liposome;
[0054] (2) Beeswax, carnauba wax, microcrystalline wax, jojoba oil, avocado oil, squalane, oleyl erucate, polyhydroxystearic acid, ce...
Embodiment 2
[0079] Table 2.1
[0080]
[0081]
[0082] The steps for preparing the above-mentioned products are as follows:
[0083] (1) Preparation of shikonin liposomes: Weigh 1.5g lecithin and 0.25g cholesterol in a round bottom flask, add 300mL petroleum ether, stir to dissolve, then add 0.5g shikonin, spin under reduced pressure at 50°C Evaporate and recover the organic solvent, and form a uniform purple-red lipid film in the round bottom flask, then add 180mL 0.9% NaCl solution, stir and elute the lipid film for 2 hours, ultrasonicate in a water bath at 26°C for 10 minutes, filter with a 0.45 μm microporous membrane, and stand for 5 minutes , repeated ultrasonication and filter membrane filtration under the same conditions, using a spray dryer to spray dry the obtained product at an inlet temperature of 130° C. to obtain 1 g of shikonin liposome;
[0084] (2) Carnauba wax, microcrystalline wax, candelilla wax, avocado oil, macadamia nut oil, polyhydroxystearic acid, cetyl et...
Embodiment 3
[0105] chart 3.1
[0106]
[0107]
[0108]
[0109] The steps for preparing the above-mentioned products are as follows:
[0110] (1) Preparation of shikonin liposomes: Weigh 2.1g lecithin and 0.4g cholesterol in a round bottom flask, add 450mL petroleum ether, stir to dissolve, then add 0.3g shikonin, spin under reduced pressure at 45°C Evaporate and recover the organic solvent, and form a uniform purple-red lipid film in the round bottom flask, then add 200mL 0.9% NaCl solution, stir and elute the lipid film for 2 hours, ultrasonicate in a water bath at 28°C for 8 minutes, filter with a 0.45μm microporous membrane, and let stand for 10 minutes , repeated ultrasonication and membrane filtration under the same conditions, using a spray dryer to spray dry the obtained product at an inlet temperature of 120°C to obtain 1.5 g of shikonin liposomes;
[0111] (2) Beeswax, microcrystalline wax, candelilla wax, jojoba oil, macadamia nut oil, polyhydroxystearic acid, octyld...
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