Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Rhodamine-based Cd<2+> fluorescent probe prepared by using Mannich reaction, and synthesis method of rhodamine-based Cd<2+> fluorescent probe

A fluorescent probe and rhodamine-based technology, applied in the direction of fluorescence/phosphorescence, chemical instruments and methods, luminescent materials, etc., can solve the problems of cumbersome synthesis steps of fluorescent probes, short excitation wavelength, low sensitivity, etc., and achieve mild reaction conditions, Simple operation and good anti-interference ability

Inactive Publication Date: 2018-10-12
QUANGANG PETROCHEM RES INST OF FUJIAN NORMAL UNIV
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the problems of cumbersome synthesis steps of fluorescent probes, short excitation wavelength, and low sensitivity, the present invention uses a Mannich reaction to prepare rhodamine-based Cd 2+ Fluorescent probe and its synthesis method

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Rhodamine-based Cd&lt;2+&gt; fluorescent probe prepared by using Mannich reaction, and synthesis method of rhodamine-based Cd&lt;2+&gt; fluorescent probe
  • Rhodamine-based Cd&lt;2+&gt; fluorescent probe prepared by using Mannich reaction, and synthesis method of rhodamine-based Cd&lt;2+&gt; fluorescent probe
  • Rhodamine-based Cd&lt;2+&gt; fluorescent probe prepared by using Mannich reaction, and synthesis method of rhodamine-based Cd&lt;2+&gt; fluorescent probe

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Step 1: Synthesize rhodamine lactam intermediate, weigh 2g of rhodamine B dye, dissolve it in ethanol solvent, then add ethylenediamine solution dropwise into rhodamine B solution, heat to 50°C, and reflux for 6h , the solution changes from maroon red to orange yellow during the reaction process, and the rhodamine B lactam intermediate is obtained;

[0029] Step 2: Synthesis of rhodamine base Cd 2+ As a fluorescent probe, rhodamine lactam (1.0mmol), paraformaldehyde (1.2mmol), and 7-hydroxycoumarin (1.5mmol) were dissolved in an organic solvent, heated to 80°C under the protection of an inert gas, and refluxed. TLC monitors the reaction process, and the reaction can be stopped until the raw material point no longer disappears. The reaction solution is cooled to room temperature, the solvent is evaporated under reduced pressure, and CHCl is added. 3 Dissolved to obtain a clear solution, and then 5% Na 2 CO 3 The solution was washed three times with water, dried over a...

Embodiment 2

[0031] Such as figure 2 As shown, add 5 times the equivalent of K to the probe solution + 、Na + , Ca2+ , Mg 2+ , Zn 2+ , Hg 2+ , Mn 2+ , Fe 3+ 、Cu 2+ , Pb 2+ When ionized, the probe solution is colorless, and the fluorescence intensity at 580nm does not change. It can be seen that the probe maintains its original structure and can exist stably in these solution systems. When Cd is added to the probe solution 2+ After that, the solution changed from colorless to red, and the fluorescence intensity at 580nm was obviously enhanced, and a strong emission peak appeared. This is due to Cd 2+ Reaction with the probe causes the rhodamine helix to open, resulting in fluorescence emission.

Embodiment 3

[0033] Such as image 3 As shown, taking the fluorescence intensity at the position of the maximum emission peak as the ordinate, and the metal ion as the abscissa, first add 5 times the equivalent of interference ions (K + 、Na + , Ca 2+ , Mg 2+ , Zn 2+ , Hg 2+ , Mn 2+ , Fe 3+ 、Cu 2+ , Pb 2 + ), then add 3 times the equivalent of Cd 2+ , the solution turns red immediately from the colorless state, and its fluorescence intensity is tested. It can be seen from the figure that, in the presence of other interfering ions, the probe is not sensitive to Cd 2+ Still have good recognition ability.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the field of cadmium ion analysis and detection, and particularly relates to a rhodamine-based Cd<2+> fluorescent probe prepared by using a Mannich reaction, and a synthesis method of the rhodamine-based Cd<2+> fluorescent probe. The structural formula of the rhodamine-based Cd<2+> fluorescent probe is represented in the figure. According to the invention, the synthesis isbased on the Mannich reaction, a condensation reaction is carried out on a certain amount of rhodamine lactam, paraformaldehyde and 7-hydroxycoumarin under a certain condition, the reaction is finished by one step, the condition is mild, and the operation is simple. The probe has good selectivity to cadmium ions, has good anti-interference ability to metal ions such as K<+>, Na<+>, Ca<2+>, Mg<2+>, Zn<2+>, Hg<2+>, Mn<2+>, Fe<3+>, Cu<2+>, Pb<2+> and the like, has the advantages of high detection sensitivity and short resolution time, can be applied to cadmium ion detection in an environmental water body sample, and has a wide application prospect.

Description

technical field [0001] The invention belongs to the field of analysis and detection of cadmium ions, and in particular relates to a rhodamine base Cd prepared by Mannich reaction. 2+ Fluorescent probes and methods for their synthesis. Background technique [0002] With the rapid development of modern industry, the problem of heavy metal ion pollution is becoming more and more serious. Among them, cadmium is widely used in industrial production, because of its good corrosion resistance to alkaline substances, it is used in plastic manufacturing and metal plating, and is also used to make batteries, produce pigments and phosphors, etc. Cadmium is not an essential element for the human body, it is a very toxic heavy metal, due to the cadmium ion (Cd 2+ ) has the characteristics of bioaccumulation, long half-life (20-30 years), and is not suitable for decomposition. Once it enters the human body through the biological chain and accumulates in the body, it can cause human lung ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D519/00C09K11/06G01N21/64
CPCC07D519/00C09K11/06C09K2211/1029C09K2211/1033C09K2211/1088G01N21/6428G01N21/643
Inventor 陈嘉炼陈登龙白欣刘金玲刘志鹏
Owner QUANGANG PETROCHEM RES INST OF FUJIAN NORMAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com