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Gastrodia elata superfine powder preparation and preparation method thereof

A technology of ultrafine powder and gastrodia elata, applied in the directions of anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc., can solve the problems of poor consumer experience, small particle size of ultrafine powder, poor solubility, etc. Good effect, less fine powder and uniform particle size

Active Publication Date: 2021-08-06
张奉明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Therefore, Gastrodia elata is widely used in clinical and health care fields, and its use methods are diverse. In recent years, the popular ultrafine pulverization is popular among consumers, but the ultrafine powder has small particle size, poor fluidity, and poor solubility, which makes the consumer experience not strong. In order to enrich the way of taking and improve the utilization rate and consumption quality of the product, a Gastrodia elata ultrafine powder preparation and its preparation method are provided

Method used

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  • Gastrodia elata superfine powder preparation and preparation method thereof
  • Gastrodia elata superfine powder preparation and preparation method thereof
  • Gastrodia elata superfine powder preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Gastrodia elata 100g, silicon dioxide 50g, lactitol 20g, mannitol 10g.

[0029] Preparation:

[0030] (1) Gastrodia elata medical material is placed in the traditional Chinese medicine slicer, is cut into the gastrodia elata sheet of 0.5mm, for subsequent use;

[0031] (2) Put the material in (1) in a universal pulverizer, control the screen mesh number to be ≥80 mesh, pulverize, collect pulverized powder, and set aside;

[0032] (3) Put the material in (2) and silicon dioxide, lactitol, and mannitol in a three-dimensional mixer, set the speed at 3 rpm, mix for 2 minutes, and set aside;

[0033] (4) Place the material in (3) in a wet granulator, add 0.1% ethanol solution with a concentration of 3% of the material weight, set the rotation speed to 2 rpm, stir for 3 minutes, and set aside;

[0034] (5) Put the material in (4) in the rubber mixing machine, control the distance between the rollers of the rubber mixing machine to be 1 mm, repeat extrusion 2 times, and set ...

Embodiment 2

[0040] Gastrodia elata 10000g, silicon dioxide 9000g, lactitol 8000g, mannitol 8000g.

[0041] Preparation:

[0042] (1) Gastrodia elata medical material is placed in the traditional Chinese medicine slicer, is cut into the gastrodia elata sheet of 8mm, for subsequent use;

[0043] (2) Put the material in (1) in a universal pulverizer, control the screen mesh number to be ≥80 mesh, pulverize, collect pulverized powder, and set aside;

[0044] (3) Put the material in (2) and silicon dioxide, lactitol, and mannitol in a three-dimensional mixer, set the speed at 15 rpm, mix for 22 minutes, and set aside;

[0045] (4) Place the material in (3) in a wet granulator, add a 75% concentration ethanol solution that is 200% times the weight of the material, set the rotating speed to 28 rpm, stir for 20 minutes, and set aside;

[0046] (5) Place the material in (4) in the rubber mixing machine, control the roller spacing of the rubber mixing machine to be 4mm, repeat extrusion 6 times, ...

Embodiment 3

[0052] Gastrodia elata 5000g, silicon dioxide 4300g, lactitol 4000g, mannitol 3800g.

[0053] Preparation:

[0054] (1) Gastrodia elata medical material is placed in the traditional Chinese medicine slicer, is cut into the gastrodia elata sheet of 4mm, for subsequent use;

[0055] (2) Put the material in (1) in a universal pulverizer, control the screen mesh number to be ≥80 mesh, pulverize, collect pulverized powder, and set aside;

[0056](3) Put the material in (2) and silicon dioxide, lactitol, and mannitol in a three-dimensional mixer, set the rotation speed at 9 rpm, mix for 12 minutes, and set aside;

[0057] (4) Place the material in (3) in a wet granulator, add a 40% concentration of ethanol solution that is 100% times the weight of the material, set the rotating speed to 15 rpm, stir for 12 minutes, and set aside;

[0058] (5) Place the material in (4) in the rubber mixing machine, control the roller spacing of the rubber mixing machine to be 2mm, repeat extrusion ...

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Abstract

The invention provides a Gastrodia elata superfine powder preparation and a preparation method thereof, which comprises 1-100 parts of Gastrodia elata, 0.5-90 parts of silicon dioxide, 0.2-80 parts of lactitol and 0.1-80 parts of mannitol. It is made through the steps of pulverization, extrusion, drying, superfine pulverization, granulation and the like. The Gastrodia elata ultrafine powder preparation prepared by the invention has uniform particle size, less fine powder, good suspension effect when dissolved in water, can reduce wall sticking and bottom sinking, improve dosage accuracy, and simultaneously improve the dissolution efficiency of active ingredients.

Description

technical field [0001] The invention relates to medicine and functional food, in particular to a Gastrodia elata superfine powder preparation and a preparation method thereof. Background technique [0002] Gastrodia elata is the rhizome of the orchid plant Gastrodia elata Bl. Also known as Guiduyou ("The Classic"), Chijian ("The Classic"), Mingma ("Clinical Guide to Medical Records"). Sweet in the mouth, flat in nature. Go into Liver Channel. Function: calming the liver, calming the wind and relieving convulsions. Indications: dizziness, dark eyes, head wind and headache, numbness of limbs, hemiplegia, astringent speech, convulsions and wind in children. "Drug Huayi" records: "Gastrodia elata, gas and slow, "Jing" says, the liver is suffering and urgent, and it is relieved with sweetness. Use this to slow the liver qi. The liver is covered with wood, and the gallbladder is wind. If the liver is deficient, it will cause liver urgency If you are strong and cannot nourish ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/8988A61K47/26A61K47/04A61P29/00A61P25/00A61P9/00A23L33/105
CPCA23V2002/00A61K9/1611A61K9/1623A61K36/8988A23L33/105A61P9/00A61P25/00A61P29/00A23V2200/30
Inventor 张奉明
Owner 张奉明