Polypeptide-protein-drug-carried solid particulate matter with mucous penetrability and preparation containing same, and preparing methods and application of polypeptide-protein-drug-carried solid particulate matter with mucous penetrability and preparation

Abstract

The invention relates to a polypeptide-protein-drug-carried solid particulate matter with mucous penetrability and a preparation containing the same, and preparing methods and application of the polypeptide-protein-drug-carried solid particulate matter with the mucous penetrability and the preparation. The solid particulate matter comprises, by weight, 0.5-90 parts, preferably 1-50 parts, of polypeptide protein drugs, 0.5-90 parts, preferably 5-50 parts, of absorption enhancers, 0-50 parts, preferably 1-30 parts, of protease inhibitors, and 5-90 parts, preferably 10-90 parts, of mucous penetrability materials. The provided mucous penetrability solid preparation contains the solid particulate matters wrapped with the mucous penetrability materials and colon-specific materials. A prepared drug delivery system can resist degradation of gastric acid and gastric intestinal enzymes to the polypeptide protein drugs during oral administration and meanwhile has the mucous penetrability and colon-specific effects, and absorption of polypeptide proteins in an intestinal tract can be effectively promoted; and a preparation technology is simple, the required cost is low, and the polypeptide-protein-drug-carried solid particulate matter with the mucous penetrability and the preparation are suitable for industrial production.

Description

technical field [0001] The present invention relates to the field of biopharmaceuticals, and more specifically relates to a mucus-penetrating solid particle containing polypeptide protein drugs, a preparation containing the solid particle, a preparation method and an application thereof. The mucus-penetrating solid preparation of the present invention is mainly used for preparing oral polypeptide and protein medicines, and has a better effect of improving the biological efficacy of polypeptide and protein medicines. Background technique [0002] Peptide protein drugs, such as insulin, human growth hormone, and calcitonin, are administered by injection. However, there are many disadvantages in injection administration, such as the short biological half-life of insulin, and 1-2 insulin injections per day will cause side effects such as local redness and swelling, subcutaneous nodules, subcutaneous fat atrophy, etc., which bring great pain and pain to patients. inconvenient. ...

AI Technical Summary

Problems solved by technology

[0005] In the above methods, some absorption enhancers have irreversible damage to cells, and the preparation process of some drug carriers is relatively complicated, which leads to many difficulties in practical application.

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