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Insulin closed-loop controlled release mechanism driven by biological fuel cell

A technology of biofuel cells and insulin, which is applied in the direction of pharmaceutical devices and other medical devices, can solve the problems of seldom considering the driving and sensing links, and the impossibility of implantable applications.

Pending Publication Date: 2018-10-19
NANJING FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, most MEMS-based drug delivery chips rely on external control signals to "passively" release drugs, and related research has only focused on the actuator itself, rarely considering the driving and sensing links, and it is far from being able to achieve implantation. application

Method used

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  • Insulin closed-loop controlled release mechanism driven by biological fuel cell
  • Insulin closed-loop controlled release mechanism driven by biological fuel cell
  • Insulin closed-loop controlled release mechanism driven by biological fuel cell

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A biofuel cell-driven insulin intelligent closed-loop controlled-release mechanism is placed in the body of a volunteer or patient. The biofuel cell will use the blood sugar in the human body as fuel, and convert the chemical energy in the fuel into electrical energy to supply power to the drug release mechanism to release the drug. The valve is bent and deformed, and the opening of the drug release port is related to the loading voltage of the drug release mechanism. The higher the concentration of blood sugar, the greater the current and voltage will be, the greater the opening of the release port, and the greater the amount of insulin entering the blood of the human body through the release port. The magnitude of the voltage and the action of the release mechanism determine the speed and dose of insulin release, and the released insulin will lower the blood sugar concentration. When the blood sugar concentration of the human body decreases, the electricity generated b...

Embodiment 2

[0051] The working process of this embodiment is the same as that of Embodiment 1.

[0052] Preparation of body parts:

[0053] (1) Preparation of the drug release mechanism: the counter electrode of the drug release mechanism is a silver electrode, and the drug release valve is composed of platinum, PPy, adhesive film, and barrier film as the working electrode. The working electrode and the counter electrode were prepared by other processes, and a layer of PPy film was deposited on the working electrode by electrochemical deposition to induce the change of the electric field. The thickness of the platinum is about 50-300 nm, and the thickness of the deposited pyrrole is about 0.5-3 μm.

[0054] (2) Preparation of biofuel cell enzyme electrode: The electrode structure of BFC is copper microelectrode structure, which is obtained by photolithography and etching process. The copper microelectrode structure will be used as the positive and negative electrodes of the BFC, and the...

Embodiment 3

[0057] The working process of this embodiment is the same as that of Embodiment 1.

[0058] Preparation of body parts:

[0059] Preparation of the drug release mechanism: the counter electrode of the drug release mechanism is a platinum electrode, and the drug release valve is composed of silver, PPy, adhesive film, and barrier film as the working electrode, and is prepared by photolithography, glue removal, and metal layer deposition. The working electrode and the counter electrode are taken out, and a layer of PPy thin film is deposited on the working electrode by electrochemical deposition to induce the change of the electric field. The thickness of the silver is about 50-300 nm, and the thickness of the deposited pyrrole is about 0.5-3 μm.

[0060] (1) Preparation of biofuel cell enzyme electrode: The electrode structure of BFC is gold microelectrode structure, and the microstructure is obtained by photolithography and etching process. The gold microelectrode structure w...

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Abstract

The invention provides an insulin closed-loop controlled release mechanism driven by a biological fuel cell. The mechanism adjust the opening degree of a medicine release opening as blood sugar concentration varies, thereby intelligently releasing medicine. The mechanism comprises the biological fuel cell taking blood sugar as a fuel and a medicine release mechanism. The medicine release mechanismcomprises two parts including a counter electrode and a medicine release valve. The medicine release valve comprises a polypyrrole layer and a metal layer, both of which are composited vertically. The biological fuel cell and the medicine release mechanism are both arranged on a monocrystalline silicon piece. The middle of the counter electrode is the medicine release valve. One end of the medicine release valve is fixed with the surface of the monocrystalline silicon piece. The monocrystalline silicon piece opposite to the surface of the metal layer is equipped with the medicine release opening. A positive electrode and a negative electrode of the biological fuel cell are connected with a chip resistor. The positive electrode and the negative electrode of the biological fuel cell are electrically connected with the counter electrode and the metal layer. Electric energy converted by the biological fuel cell is used for driving the medicine release mechanism. The polypyrrole layer expands or contracts due to effect of an electric field. The medicine release valve warps such that the medicine release valve closes, opens or partially opens the medicine release opening.

Description

technical field [0001] The invention relates to the field of drug sustained release, in particular to an intelligent insulin control release mechanism driven by a biofuel cell. Background technique [0002] With the general improvement of people's quality of life and the increase in the proportion of the elderly population, the incidence of diabetes has increased year by year, and it has become the third most dangerous disease after cardiovascular and cancer, seriously threatening people's health and normal life. Insulin is the most effective drug for treating diabetes and plays an irreplaceable role in the treatment of diabetes. [0003] In order to effectively exert the function of insulin and achieve a good therapeutic effect, it is necessary to select the appropriate drug carrier, drug dosage form and route of administration so that the body can effectively absorb the drug. At present, injection administration is still the main method. In order to achieve the persisten...

Claims

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Application Information

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IPC IPC(8): A61M31/00
CPCA61M31/002A61M2230/201A61M2205/8206A61M2205/825A61M2230/005
Inventor 习爽左双双朱银龙刘英杨雨图郁毛林缑斌丽
Owner NANJING FORESTRY UNIV
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