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Cefixime capsule preparation method

A technology of cefixime and capsules, which is applied in the field of capsule preparation, can solve the problems of cefixime capsules hazards and liquid paraffin hazards to human body, and achieve better dispersion effect, lower dissolution rate and remarkable effect

Inactive Publication Date: 2018-10-23
SICHUAN XINGZHI ZHIHUI INTPROP OPERATION CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention solves the problem that the formula of cefixime capsules in the prior art has certain hazards; it provides a method for preparing cefixime capsules that solves the above problems, and can effectively solve the problem of liquid paraffin wax by optimizing the composition and proportioning ratio. Harmful to the human body, it can also achieve the dissolution rate of the existing cefixime composition, and the effect is very significant

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A method for preparing cefixime capsules, comprising a capsule shell and granules arranged in the capsule shell, the granules comprising:

[0034] 3-7 parts of cefixime;

[0035] 1-3 parts of microcrystalline cellulose;

[0036] 16-20 parts of pregelatinized starch;

[0037] Micropowder silica gel 2-4 parts;

[0038] 1-3 parts of hydrogenated vegetable oil.

[0039] In this embodiment, the preferred amount of cefixime is 5 parts; the preferred amount of microcrystalline cellulose is 3 parts; the preferred amount of pregelatinized starch is 17 parts; the preferred amount of micronized silica gel is 3 parts; and the preferred amount of hydrogenated vegetable oil is 2 parts.

[0040] The preparation technology of above-mentioned cefixime granule capsule is as follows:

[0041] First, mix cefixime and hydrogenated vegetable oil evenly according to the proportion, then add microcrystalline cellulose and micropowder silica gel in sequence and mix evenly;

[0042] Next, a...

Embodiment 2

[0047] The difference between this embodiment and Embodiment 1 is that the specific composition ratio is optimized in this embodiment, and the specific settings are as follows:

[0048] In this embodiment, cefixime is preferably 7 parts; microcrystalline cellulose is preferably 2 parts; pregelatinized starch is preferably 20 parts; micronized silica gel is preferably 2 parts; and hydrogenated vegetable oil is preferably 3 parts.

[0049] The capsules prepared in this example were used for the dissolution test, and the results showed that the dissolution rate after 30 minutes was 95%, the dissolution rate after 6 months was 93%, and the dissolution rate after 12 months was 95%.

Embodiment 3

[0051] This example is a comparative example. In this example, the granules include: 40 parts of cefixime; 4 parts of magnesium stearate; 130 parts of pregelatinized starch; preferably 2 parts of hydrogenated vegetable oil.

[0052] The capsules prepared in this example were used for the dissolution test, and the results showed that the dissolution rate after 30 minutes was 82%, the dissolution rate after 6 months was 73%, and the dissolution rate after 12 months was 69%.

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Abstract

The invention discloses a cefixime capsule preparation method and solves the problem that a cefixime capsule formula in the prior art has certain harms. The cefixime capsule preparation method includes: firstly, well mixing cefixime with hydrogenated vegetable oil proportionally, sequentially adding microcrystalline cellulose and aerosil, and well mixing; secondly, adding pre-gelatinized starch, and well mixing; finally, subjecting well mixed materials to dry pressing and granulating, filtering through a 40-mesh screen to obtain granules, and adding the granules into capsule shells to obtain finished products. Cefixime capsules are prepared from, by weight, 3-7 parts of cefixime, 1-3 parts of microcrystalline cellulose, 16-20 parts of pre-gelatinized starch, 2-4 parts of aerosil and 1-3 parts of hydrogenated vegetable oil. Effectiveness in dispersion of cefixime into pre-gelatinized starch is realized, and excellent dispersion effects are achieved. In addition, the hydrogenated vegetable oil can be absorbed by human bodies, and harms are avoided.

Description

technical field [0001] The invention relates to a method for preparing capsules, in particular to a method for preparing cefixime capsules. Background technique [0002] Cefixime, the English name is Cefixime, the Chinese aliases are acetioxime cephalosporin, Shifusu granules, and the CAS number is 79350-37-1. It is a third-generation cephalosporin antibiotic and is absorbed through the gastrointestinal tract when taken orally. Finally, it can prevent the synthesis of bacterial cell walls and play an antibacterial effect, which is safe, efficient and resistant to enzymes. Cefixime is white to light yellow crystalline powder, bitter and slightly specific odor, unstable to damp heat, easily soluble in methanol and dimethyl sulfoxide, slightly soluble in acetone, hardly soluble in ethanol, almost insoluble in water, Ethyl acetate, ether, hexane. [0003] At present, oral preparations of cefixime mainly include tablets, dispersible tablets, dry suspensions and capsules. Its p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/44A61K47/04A61K31/546A61P31/04
CPCA61K9/1617A61K9/1611A61K31/546A61P31/04
Inventor 周豪
Owner SICHUAN XINGZHI ZHIHUI INTPROP OPERATION CO LTD
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