Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Non-steroidal anti-inflammatory eye drops and preparation method thereof

A technology of non-steroidal anti-inflammatory eye drops, which is applied in the field of medicine, can solve the problems of non-steroidal anti-inflammatory eye drops in terms of comfort and stability, and achieve significant economic benefits, strong targeting effect, and penetration powerful effect

Inactive Publication Date: 2018-11-02
广州君博医药科技有限公司
View PDF5 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Aiming at the problem that the existing non-steroidal anti-inflammatory eye drops are insufficient in terms of medication comfort and stability, the object of the present invention is to provide an eye drop with good medication comfort, strong stability and wide application range , and the present invention also provides the preparation method and application of the eye drops

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Non-steroidal anti-inflammatory eye drops and preparation method thereof
  • Non-steroidal anti-inflammatory eye drops and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] The present invention also provides the preparation method of this non-steroidal anti-inflammatory eye drop, it is characterized in that comprising the steps:

[0025] A, disperse the flurbiprofen prodrug with an appropriate amount of water for injection, and set aside to obtain liquid A;

[0026] B. Disperse the thickener with an appropriate amount of water for injection and let it cool, then add the antibacterial agent, stir well and filter, add to the liquid A obtained in step A) to obtain liquid B;

[0027] C. Dissolve the pH adjuster with water for injection, slowly add it to liquid B, adjust the pH value to 5.5-7.5, and obtain liquid C;

[0028] D. Dissolve the osmotic pressure regulator with water for injection, slowly add to the solution C obtained in step 3), adjust the osmotic pressure molar concentration to 250-350mOsmol / kg, and obtain liquid D;

[0029] E. Add water for injection to the liquid D to make up the volume, so that the concentration of flurbiprof...

Embodiment 1-10

[0033] Raw materials and proportioning situation of table 1 eye drops

[0034]

Embodiment 1

[0036] At first will prepare raw materials by formula shown in table 1;

[0037] Step 1), dissolve the flurbiprofen prodrug with 50% water for injection, and set aside;

[0038] Step 2), disperse the thickener with water for injection and let cool, then add the antibacterial agent, stir and filter, and add to the flurbiprofen prodrug solution obtained in step 1);

[0039]Step 3), dissolve the pH regulator with water for injection, slowly add in the flurbiprofen prodrug solution obtained in step 2), adjust the pH value to 5.5 and stop;

[0040] Step 4), dissolve the osmotic pressure regulator with water for injection, slowly add to the solution obtained in step 3), adjust the osmotic pressure molar concentration to 250mOsmol / kg and stop adding;

[0041] Step 5), add water for injection to 100ml, filter, sub-package, to get final product;

[0042] Thimerosal is used as antibacterial agent, polyvinyl alcohol is used as thickener, sodium hydroxide solution and / or hydrochloric ac...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses non-steroidal anti-inflammatory eye drops. Per 100mL of the eye drops include the following components: 0.01-0.5g of a flurbiprofen precursor drug, 0.0004-0.5g of a bacteriostatic agent, 0.1-0.5g of a thickener, a pH regulator, an osmotic pressure regulator, and the balance water for injection. The flurbiprofen precursor drug is flurbiprofen axetil or a pharmaceutically acceptable salt of flurbiprofen. The pH value of the eye drops is 5.5-7.5, and the osmotic pressure molar concentration of the eye drops is 250-350mOsmol / kg. The invention also provides a preparation method of the eye drops. The eye drops provided by the invention have the advantages of strong comfort, no irritation, good efficacy and the like, and the preparation method is easy for industrial production.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a non-steroidal anti-inflammatory eye drop and a preparation method thereof. Background technique [0002] Flurbiprofen prodrugs are propionic acid non-steroidal anti-inflammatory drugs (NSAIDs), and its mechanism of action is to inhibit the activity of cyclooxygenase and block the synthesis of prostaglandins. Prostaglandins are mediators of certain intraocular inflammations, which can cause blood-aqueous barrier breakdown, vasodilation, increased vascular permeability, leukocyte chemotaxis, and miosis unrelated to cholinergic mechanisms. Clinical studies have shown that this product can inhibit the miosis during cataract surgery, and has no significant effect on intraocular pressure. Its analgesic effect is 10-20 times stronger than ketoprofen, indomethacin, and naproxen. It has powerful and balanced analgesic, anti-inflammatory, and antipyretic effects; it is safer to use, and the inci...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/08A61K31/192A61K31/222A61P27/02A61P29/00
CPCA61K9/0048A61K9/08A61K31/192A61K31/222A61K47/02A61K47/32A61P27/02A61P29/00
Inventor 谭上彬王延东崔明黄俊杰陈宇明
Owner 广州君博医药科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com