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Chinese medicine effective part for treating depressive disorder and insomnia, preparation method and application thereof

A technology of effective parts and traditional Chinese medicines, which is applied to the effective parts of traditional Chinese medicines for treating depression and insomnia and the fields of preparation and application thereof, can solve the problems of clinical application limitation, respiratory inhibition, narrow antidepressant spectrum, etc., and achieves significant antidepressant and sedative effects. Hypnotic activity, good economic benefits and application prospects, the effect of improving appearance and solubility

Inactive Publication Date: 2018-11-02
TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of depression and insomnia is mainly based on synthetic drugs. Although the therapeutic effect of these drugs is very ideal, most of the antidepressant western medicines have the characteristics of narrow antidepressant spectrum and large toxic side effects. For example, MAOI may cause toxic liver damage in patients and hypertensive crisis, TCA may cause constipation, urinary retention and blurred vision in users due to its obvious anticholinergic effect, and even cause serious adverse reactions such as orthostatic hypotension, arrhythmia and myocardial infarction in patients
However, sedative hypnotics have sequelae such as dizziness and drowsiness, and have an inhibitory effect on breathing. Long-term use may cause adverse reactions such as tolerance and addiction, which limits their clinical application.

Method used

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  • Chinese medicine effective part for treating depressive disorder and insomnia, preparation method and application thereof
  • Chinese medicine effective part for treating depressive disorder and insomnia, preparation method and application thereof
  • Chinese medicine effective part for treating depressive disorder and insomnia, preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Preparation method of SHF effective part

[0026] 1. The preparation method of effective part of SHF

[0027] Weigh the four medicinal materials by weight (24g jujube seed, 13g bark of Albizia juniper, 6g white peony root, 10g cypress kernel), pulverize, heat and reflux with 10 times the amount and 8 times the amount of 70% ethanol for 2h and 1h respectively, filter, and combine The filtrate; the filtrate is concentrated under reduced pressure to the liquid extract, which is the compound SHF, for subsequent use; the liquid extract is dissolved in water, passed through the treated AB-8 macroporous adsorption resin, dissolved in distilled water respectively, passed through the treated AB-8 large Pore ​​adsorption resin, eluted with 7BV 1% NaOH solution, 4BV distilled water, 5BV 70% ethanol solution respectively. The ethanol eluate was collected, concentrated under reduced pressure, and dried to obtain the effective fraction of SHF, wherein the percentage of total terpeno...

Embodiment 2

[0035] Experimental Study on Effective Parts of SHF in Treating Depression and Insomnia

[0036] 1. Experimental materials

[0037] 1.1 Experimental animals: 70 male ICR mice (clean grade, body weight 20±2g) from the Experimental Animal Center of the Institute of Radiological Medicine, Chinese Academy of Medical Sciences, certificate number: SCXKjin 2005-0001. Raised in the laboratory for 1 week before the experiment to adapt to the environment. The room temperature is 22±2°C, and the relative humidity is 65% to 70%. Sunlight for 12 hours, food and water ad libitum.

[0038] 1.2 Drugs and reagents: SHF extract, SHF active part extract (self-made in our laboratory); Venlafaxine hydrochloride sustained-release capsules (Effexor, Wyeth Pharmaceuticals, Ireland, batch number: 0902052).

[0039] 1.3 Experimental instruments: BP211D 1 / 100,000 analytical balance (Shanghai Junda Instrument Factory); R204 rotary evaporator (Shanghai Shensheng Technology Co., Ltd.); SHB-IIIA circulat...

Embodiment 4

[0101] Preparation of effective fraction granules

[0102] 1. Prescription screening of granules

[0103]1.1 Selection of excipients According to the prescription designed in Table 7, take quantitative effective part dry cream powder and excipients (through 80 mesh sieve) and pass through 40 mesh sieve, mix evenly, use 70% ethanol as binder to make soft material, pass through 20 mesh sieve to granulate, 60U Blow drying for 20 minutes, pass through a 18-mesh sieve for granulation, and dry at 60°C for 10mm. Calculate the fine powder rate, see Table 7.

[0104] 1.2 Determination of Solubility Precisely weigh 1.0g of each of the three granules under Item 1.1, add 200mL of water at about 60°C, shake, and measure the time required for complete dissolution. The appendix of the 2010 edition of the Chinese Pharmacopoeia stipulates that the granules should be completely dissolved within 5 minutes, and slight turbidity is allowed. Results The three granules were all dissolved in 2 minu...

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Abstract

The invention discloses a Chinese medicine compound effective part for treating depressive disorder and insomnia, a preparation method and application of the Chinese medicine compound active part. Chinese herbal compound suanzaoren hehuan formula is extracted by ethanol, concentrated, purified by macroporous resin, and eluted with aqueous slkali to collect 50%-80% ethanol solution elution part, sothat total terpene effective part can be obtained. The obtained effective part mainly comprises albiforin,(-)-syringaresinol-4-0-Beta-D-apiofuranosy-(1 arrow 2)-Beta-D- glucopyranoside, betulinic acid, botulin and daucosterol. Experiment results shows that the effective part provided by the invention has remarkable effects of anti-depression and sedative-hypnotic activity, can be applied to prevent and treat depressive disorder and insomnia at the same time, and has very good economic benefits and application prospects.

Description

technical field [0001] The invention relates to an effective part of a traditional Chinese medicine for treating depression and insomnia, a preparation method and an application thereof, in particular to an effective part of a compound Chinese medicine, a preparation method and an application thereof. Background technique [0002] Insomnia caused by depression is the most common sleep disorder. Both insomnia and depression belong to the category of emotional diseases, and are closely related to liver stagnation. The China Sleep Research Society determined that the theme of Sleep Day in 2015 is "Healthy Mental Health, Good Sleep". According to the World Health Organization survey, more than one-third of the world's population has sleep disorders, and the number of people with various sleep disorders in China is as high as 38.2%. Among them, psychological factors are the main factors causing sleep problems. Modern medical research has proved that sleep disorders are closely...

Claims

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Application Information

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IPC IPC(8): A61K36/725A61K31/7048A61P25/20A61P25/24A61K31/56A61K31/704
CPCA61K31/56A61K31/704A61K31/7048A61K36/14A61K36/48A61K36/65A61K36/71A61K36/725A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 乔卫段宏泉杨旭李俊强李冰洁宋伟王冉冉
Owner TIANJIN MEDICAL UNIV
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