A kind of high molecular weight pullulan polysaccharide additive and its application in capsule preparation

A technology of pullulan polysaccharide and high molecular weight, which is applied in the field of capsule preparations, and can solve the problems of weak gelling ability of starch solution, rapid molding, and reduced storage stability.

Active Publication Date: 2021-10-22
OCEAN UNIV OF CHINA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the gelling ability of the starch solution is weak and cannot be quickly formed on the surface of the mold, so it is not suitable to use the traditional dipping method to prepare hollow ha

Method used

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  • A kind of high molecular weight pullulan polysaccharide additive and its application in capsule preparation
  • A kind of high molecular weight pullulan polysaccharide additive and its application in capsule preparation
  • A kind of high molecular weight pullulan polysaccharide additive and its application in capsule preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Example 1 Separation and Purification of High Molecular Weight Pullulan

[0063] The instruments and equipment involved in the embodiment 1 of table 1

[0064] equipment name model supplier high power electric mixer SHF-DY Ningbo Xinyi Biotechnology Co., Ltd. Digital display constant temperature water bath XMDT-204 Changzhou Zhiborui Instrument Manufacturing Co., Ltd. electronic analytical balance ME104E / 02 Mettler-Toledo Instruments Ltd. Electric constant temperature blast drying oven DHG-9030A Shanghai Qixin Scientific Instrument Co., Ltd. Kjeldahl nitrogen analyzer SKD-1000 Shanghai Peiou Desktop High Speed ​​Refrigerated Centrifuge TGL-20M Xiangyi Group Electronic Display pH Meter STARTER3100 Changzhou Danrui Experimental Instrument Co., Ltd. muffle furnace TOL-1400A Tianyuan Instrument Co., Ltd. Atomic Absorption UV Spectrophotometer GGX-100 Haiguang Instrument Co., Ltd. ...

Embodiment 2

[0103] Embodiment 2 pullulan film preparation

[0104] 1, adopt the PLA pullulan polysaccharide (referred to as P4) that embodiment 1 makes, utilize cast method to prepare pullulan polysaccharide film; And, set 3 groups of low molecular weight pullulan polysaccharide comparison groups, wherein, P1 is Mw =88290 pullulan (food grade, purchased from Zibo United Technology Chemical Co., Ltd.), P2 is the pullulan of Mw=140800 (food grade, purchased from Zhongke Hongji Biotechnology Co., Ltd.), P3 is Mw =174200 pullulan (food grade, purchased from Zhongke Hongji Biotechnology Co., Ltd.).

[0105] Weigh 2.7 g of P1 pullulan, dissolve it in 120 mL of distilled water, and prepare a 30 g / L pullulan solution. 120mL pullulan solution is equally divided into four parts, placed in four small beakers, and 0%, 10%, 20%, and 30% of the pullulan quality are added to the pullulan solution in the beakers. Glycerin was stirred magnetically at 800rpm, and after mixing, the air bubbles in the solu...

Embodiment 3

[0122] Embodiment 3 capsule preparation

[0123] (1) Prepare the glue solution: according to the proportioning requirements, the PLA pullulan polysaccharide (P4) prepared in Example 1 of 110g / L, 0.2g / L gellan gum (food grade, purchased from Shandong Zhongkai Food Ingredients Co., Ltd. ) and 0.8g / L potassium citrate and glycerol (glycerol addition is 10% of the P4 pullulan quality), pour in the 150mL beaker that fills 100mL distilled water, prepare 100mL mixed glue, then put into 80 ℃ water bath In the pot, stir continuously until the polysaccharide is completely dissolved. The dissolved glue was degassed, kept at 45°C for 30 minutes, and set aside.

[0124] (2) Glue dipping: at 15°C, slowly insert the 0# capsule mold vertically downward into the prepared glue solution, pull out the mold at a constant speed after standing for 5 seconds, and fix the pulled out capsule mold on the support placed in a drying oven at 50°C for 30 min.

[0125] (3) Shelling and cutting: the dried ...

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Abstract

The invention belongs to the technical field of capsule preparations; the invention provides a high molecular weight pullulan polysaccharide additive and a preparation method thereof. , the main component of which is high molecular weight pullulan, with a weight-average molecular weight of ≥1.8×10 5 ; The total nitrogen content of the high molecular weight pullulan additive is ≤0.05%. The present invention provides a film product such as a hard capsule, and also provides a preparation method for the hard capsule. Using the high-molecular-weight pullulan additive provided by the present invention, the prepared capsule has strong gas barrier and impact resistance , good quality stability, not brittle, stable disintegration, not easy to be hydrolyzed, the capsule is used to replace gelatin capsules and is superior to vegetable starch capsules, etc., and has broad application prospects.

Description

technical field [0001] The invention belongs to the technical field of capsule preparations, and in particular relates to a high molecular weight pullulan additive and its application in capsule preparation, specifically a high molecular weight pullulan additive and a preparation method thereof, a film product and a A preparation method of a hard capsule. Background technique [0002] Hard capsule preparations are prepared by making uniform powder or granules of medicines and pharmaceutical auxiliary materials, and filling them into hollow capsules. In the production of modern preparations, hard capsules have been widely used in recent years because they have many advantages such as easy expansion, taste masking, and drug protection. At present, hard capsules are one of the largest solid preparations prepared by pharmaceutical companies in various countries. According to the literature, the total production and sales of hard capsules in the world in 2016 was about 3.5 trill...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K9/48A61K31/43A61P31/04A23L33/125A23P10/30
CPCA61K9/4816A61K31/43A23L33/125A23P10/30A61P31/04
Inventor 刘晨光池哲池振明丁园园于钰丁松李生慧
Owner OCEAN UNIV OF CHINA
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