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A composition for prolonging skin aging and improving its function and its preparation method

A technology for skin aging and composition, which is applied in the field of anti-aging composition and its preparation, which can solve the problems of unsustainable and poor long-term effects, need for repeated injections, and poor viscosity, etc., so as to achieve fast adaptation of cells to the culture environment and increase the amplification efficiency , prevent the effect of pro-inflammatory response

Active Publication Date: 2022-03-11
天晴干细胞股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the paracrine ability of fibroblasts is weak, and the simple use of self-transplantation of fibroblasts can improve local skin texture, wrinkles, collagen secretion massage, etc. and is safe, but the effect on skin UV spots and brown spots is not good; in addition After simple fibroblast transplantation, the secretion of collagen will be gradually reduced due to changes in the body environment, so the sustained effect is poor, and repeated injections are required to maintain a good anti-aging effect; if cytokine injection is performed alone, Or platelet plasma injection, due to its poor viscosity, can not support the base tissue, so there will be problems such as insignificant short-term effect and long-term effect.

Method used

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  • A composition for prolonging skin aging and improving its function and its preparation method
  • A composition for prolonging skin aging and improving its function and its preparation method
  • A composition for prolonging skin aging and improving its function and its preparation method

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specific Embodiment approach 1

[0039] Specific embodiment one: a composition for prolonging skin aging and improving its function, its active ingredients include platelet factor with a mass percentage of 40-50%, and a concentration of 2-10×10 7 Fibroblasts per mL, low molecular weight hyaluronic acid with a mass percentage of 20-30%, laminin with a concentration of 1-10 μg / mL, superoxide dismutase with a concentration of 20-50 ng / mL, and a concentration of 5-5.5 mg / mL sodium gluconate, 2-2.5 mg / mL sodium acetate, 5-5.5 mg / mL sodium chloride, 0.3-0.5 mg / mL potassium chloride and 0.1 -0.2 mg / mL of magnesium chloride.

specific Embodiment approach 2

[0040] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the pH of the combination is 6.7-7.4. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0041] Specific embodiment three: the difference between this embodiment and specific embodiment one is: its active ingredient includes the platelet factor that mass percent content is 40~50%, concentration is 2~10×10 7 Fibroblasts per mL, low molecular weight hyaluronic acid with a mass percentage of 20-30%, laminin with a concentration of 1-10 μg / mL, superoxide dismutase with a concentration of 20-50 ng / mL, and a concentration of Sodium gluconate at 5.02 mg / mL, sodium acetate at 2.22 mg / mL, sodium chloride at 5.25 mg / mL, potassium chloride at 0.38 mg / mL, and magnesium chloride at 0.14 mg / mL.

[0042] Others are the same as in the first embodiment.

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Abstract

A composition for prolonging skin aging function and improving its preparation method. It relates to a composition and its preparation method. The short-term effect is not obvious and the long-term effect is not long-lasting due to the poor effect of continuous secretion, the poor viscosity of the local simple factor injection, the weak support effect on the base tissue, and the poor ability to balance the cells and tissues. The active ingredients of the composition of the present invention include platelet factor, fibroblast, low molecular weight hyaluronic acid, laminin, superoxide dismutase, sodium gluconate, sodium acetate, sodium chloride, potassium chloride and magnesium chloride. The present invention can prolong the effect of improving skin aging function. Through the application of this combination, the effect of pure platelet factor and pure fibroblast on improving skin aging function can be prolonged.

Description

technical field [0001] The invention belongs to the field of biotechnology, and relates to an anti-aging composition and a preparation method thereof. Background technique [0002] Skin aging is caused by both its own reasons and the external environment. After birth, the skin tissue is gradually perfected and its function is gradually strengthened, but when it reaches a certain period, it will begin to degenerate. This degeneration often has no prominent external manifestations but proceeds slowly without awareness. Generally, when a human reaches the age of 25, the growth of the skin will proceed simultaneously with aging, and the aging of the skin will become more and more obvious as time goes by at the age of 30. Skin aging is mainly manifested in dryness, roughness, pigmentation, relaxation, and the gradual formation of spots and wrinkles. After aging, the protective barrier ability of the stratum corneum of the skin decreases, the fibroblasts gradually decrease, the ...

Claims

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Application Information

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IPC IPC(8): A61K8/98A61K8/73A61K8/66A61K8/64A61K8/365A61K8/36A61K8/20A61Q19/08A61Q19/02A61Q19/00C12N5/077
CPCA61Q19/00A61Q19/02A61Q19/08A61K8/20A61K8/36A61K8/365A61K8/64A61K8/66A61K8/735A61K8/981A61K8/983C12N5/0656A61K2800/592A61K2800/5922C12N2509/00
Inventor 张怡王浩宇车彦川王琳娜刘煜刘艳青
Owner 天晴干细胞股份有限公司
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