Preparation method and application of a gold@gadolinium-based coordination polymer nanocomposite material
A technology of nanocomposite materials and coordination polymers, applied in the preparation/processing of rare earth metal compounds, rare earth metal compounds, nanotechnology, etc., can solve problems such as low relaxation rate, achieve simple synthesis methods, enhance imaging signals, The effect of good biocompatibility
Active Publication Date: 2021-10-22
JIANGXI NORMAL UNIV
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Problems solved by technology
In rare earth UCNPs, rare earth gadolinium ions (Gd 3+ ) has a large magnetic moment due to seven unpaired electrons, and is currently the most widely used magnetic contrast agent in clinical practice, but the low relaxation rate of Gd and certain nephrotoxicity affect its application, so the development of low toxicity Magnetic contrast agents with strong relaxation properties are very meaningful
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[0023] Firstly, 0.1mmol allantoin was dissolved in 20mL water and heated until dissolved, then cooled to room temperature; secondly, boiled sodium citrate solution (1mL, 0.035mol / L) and gold nanoparticle solution (2mL) were respectively injected, mixed evenly and placed in Stir magnetically at room temperature for 5 minutes; finally, take a certain concentration of Gd(NO 3 ) 3 , Yb(NO 3 ) 3 , Er(NO 3 ) 3 Aqueous solution (5 mL, 0.02 mol / L) was mixed with the above solution, magnetically stirred at room temperature for 5 minutes, and placed in a 50 mL polytetrafluoroethylene-lined reactor at 160°C for 15 hours. After the reaction was complete, it was cooled to room temperature, centrifuged, and the product was washed three times with deionized water and ethanol. After drying in a vacuum oven at 60°C for 12 hours, a purple product was obtained, and the sample was designated as Au@GdCP.
[0024] figure 1 are the SEM and TEM images of GdCP and Au@GdCP. from figure 1 It ca...
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Abstract
The present invention relates to the utilization of a one-pot method to combine GdCP with up-converting luminescent properties: Yb 3+ , Er 3+ (GdCP) nanoparticles combined with gold nanoparticles (AuNPs) to prepare gold@gadolinium-based coordination polymer core-shell structure multifunctional nanocomposites (Au@GdCP), and apply it to T 1 Weighted MRI (T 1 ‑MRI) imaging. In the present invention, the gold nanoparticles, due to their strong plasmon resonance effect (LRET), can increase the magnetic field intensity around the GdCP and play a role in improving contrast relaxation rate and MRI imaging effect. The hydrothermal synthesis method adopted in the present invention has the advantages of simple synthesis path, easy regulation, green and high efficiency, and the like. Due to its good biocompatibility, Au@GdCP can be further investigated for its application in magnetic resonance imaging, which provides a new way to obtain high-efficiency magnetic resonance imaging materials.
Description
technical field [0001] The invention relates to the field of rare earth up-conversion nanomaterials, in particular to a gold@gadolinium-based coordination polymer nanocomposite material and its method and application. Background technique [0002] Magnetic resonance imaging (MRI) is a non-radiation imaging technique that can be used to observe the structure of diseased tissues, including solid tumors, and is an effective mode of clinical diagnosis. It plays the role of contrast imaging by changing the longitudinal and transverse relaxation time of the water environment in the body. It has the advantage that it does not require ionizing radiation and provides high spatial resolution and high contrast 3D images. [0003] Rare-earth up-conversion nanomaterials (Up conversion, UCNPs) are excited by continuous visible light, and through the reverse Stokes process, multi-photon absorption or energy transfer, they can display unique, high-energy, narrow emission spectra. Based on...
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IPC IPC(8): A61K49/08A61K49/18B82Y5/00B82Y15/00C01F17/10
CPCA61K49/08A61K49/183B82Y5/00B82Y15/00C01P2004/03C01P2004/04C01P2004/34C01P2004/62C01F17/30
Inventor 钟声亮肖琛王雷陈燕红宁海金徐先进
Owner JIANGXI NORMAL UNIV