Injectable biocompatible bone matrix used for facial bone repair and preparation method thereof

A biocompatibility and bone matrix technology, applied in the field of bioengineering, can solve problems such as cartilage defects, large surgical incisions, and obvious recovery marks, and achieve the effects of good combination, high initial strength, and easy repair

Inactive Publication Date: 2018-11-06
宣城南巡智能科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the commonly used treatment methods for cartilage injury are transplantation of autologous cartilage or transplantation of allogeneic cartilage, but new cartilage defects are likely to occur when autologous cartilage is transplanted, and there is an immunogenic reaction in allogeneic cartilage transplantation, so the regeneration and repair of cartilage damage ha

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0019] Example 1:

[0020] An injectable biocompatible bone matrix for facial bone repair, which is composed of decellularized homogenous or heterogeneous cartilage with a mass fraction of 7.5 parts, a mass fraction of 7.5, and degreasing, decalcification, and decellularization processes. Said cartilage homogenous bone tissue, a mass fraction of 10 collagen fibrils, and a mass fraction of 75 parts of distilled water are mixed in a physiological state. This formula contains the decellularized cartilage of the same species or heterogeneity and the mass fraction of collagen fibrils. Therefore, the prepared bone matrix material has better growth and initial strength. The bone matrix material made according to this formula has better growth and initial strength.

Example Embodiment

[0021] Example 2:

[0022] An injectable biocompatible bone matrix for facial bone repair, which consists of 5 parts decellularized homogenous or heterogeneous cartilage, 10 mass fractions and degreasing, decalcification, and decellularization processes. Said cartilage homogenous bone tissue, a mass fraction of 10 collagen fibrils, and a mass fraction of 75 parts of distilled water are mixed in a physiological state. The mass fraction of the same or heterogeneous cartilage that has undergone decellularization used in this formula is relatively small, but the mass fraction of the cartilage of the same species that has undergone degreasing, decalcification, and decellularization has a greater mass fraction. According to this implementation The bone matrix prepared in Example 1 has higher initial strength than Example 1. The bone matrix material made according to this formula has higher initial strength than that of Example 1.

[0023] Further, the physiological state is a pH value ...

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PUM

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Abstract

The invention discloses an injectable biocompatible bone matrix used for facial bone repair and a preparation method thereof. The injectable biocompatible bone matrix is formed by mixing 5 to 10 partsof homogeneous or heterogeneous soft bone through acellular disposal, 5 to 10 parts of bone tissues homogeneous with the soft bone through degreasing, decalcification and decellularization, 10 partsof collagen fibril and 75 parts of distilled water in physiological conditions. The injectable biocompatible bone matrix has the beneficial effects that the binding performance of the material with human bones is preferable by simulating the composition of human body soft bones, the initial strength is relatively high, rapid repair for human body soft bone tissue damage is facilitated, and the injectable biocompatible bone matrix can be applicable to nose beautifying.

Description

technical field [0001] The invention belongs to the technical field of bioengineering, in particular to an injectable biocompatible bone matrix for facial bone repair. Background technique [0002] Cartilage is the basic raw material for human bone development. When human cartilage tissue is damaged, the cartilage regeneration ability is poor due to the limited cartilage repair ability of the human body. Leading to damage to cartilage is known as one of the problems of orthopedic surgery. [0003] At present, the commonly used treatment methods for cartilage injury are transplantation of autologous cartilage or transplantation of allogeneic cartilage, but new cartilage defects are likely to occur when autologous cartilage is transplanted, and there is an immunogenic reaction in allogeneic cartilage transplantation, so the regeneration and repair of cartilage damage has become an important issue in orthopedics. Clinical research hotspot. [0004] Modern surgical operations ...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/24
CPCA61L27/24A61L27/3633A61L27/3654A61L2430/06
Inventor 张培英
Owner 宣城南巡智能科技有限公司
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