Multifunctional coating of biodegradable scaffold and preparation method thereof

Abstract

The invention provides a multifunctional coating of a biodegradable polymer stent and a preparation method thereof. An innermost coating layer is prepared from an anticoagulation drug and a drug carrier (water soluble chitosan and a cross-linking agent genipin); a middle coating layer is prepared from a cell proliferation resistant fat soluble drug and a drug carrier (polymer PLCL and a cross-linking agent HDI); and the outermost coating layer is prepared from an anticoagulation drug, an endothelialization enhancement drug and a drug carrier (water soluble chitosan and a cross-linking agent genipin), and the outermost coating layer is only prepared on the inner side of the stent. The preparation method adopts a dip-coating method to prepare the coating, the technology is simple, the requirement to the equipment is low, the prepared three-layered drug carrying polymer coating can achieve time sequence release of different drugs, reduces formation of thrombus at the early stage and the later stage, promotes endothelialization, inhibits proliferation of smooth muscle cells, and decreases the in-stent restenosis, meanwhile, the middle layer of elastomer coating completes wraps the stent body, the damage of the stent after being pressed and held and expanded is reduced, and the radial supporting property of the stent is improved.

Description

technical field [0001] The invention belongs to the technical field of implanted medical devices, and in particular relates to a multifunctional coating of a biodegradable polymer stent and a preparation method thereof. Background technique [0002] According to the research of the World Health Organization, coronary artery disease will become the main cause of human death, and the main manifestation of coronary artery disease is the appearance of atheromatous plaque on the inner wall cavity of the blood vessel. Currently, the most effective way to treat coronary artery disease is drug-eluting stents (Drug-eluting stents, DES). The metal of the DES body will remain in human blood vessels for a long time, hindering the reconstruction of blood vessels in the later stage, and causing a series of complications, such as late thrombosis and allergic reactions. Biodegradable stents (Bioresorbable stents, BRS) provide radial support to diseased stenotic vessels, and then gradually ...

AI Technical Summary

Problems solved by technology

However, a large number of clinical results show that the rate of late thrombosis caused by BRS is higher than that of DES, so it needs to be improved.

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