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Controlled-release type scar repairing and beautifying gel material and preparation method

A gel material and scar technology, applied in the field of medical cosmetology, can solve problems such as poor controllability, poor scar repair effect, and difficulty in effectively restoring metabolic function, and achieves good controlled release effect.

Inactive Publication Date: 2018-11-13
CHENDU NEW KELI CHEM SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] It can be seen that the technical methods for scar repair in the prior art, including the method of using TGC protease for scar repair, generally have poor controllability, slow release effect is not as good, it is difficult to effectively penetrate into the skin, and it is difficult to effectively restore metabolism. Function, scar repair effect is poor

Method used

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  • Controlled-release type scar repairing and beautifying gel material and preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] a. Disperse commercially available TGC protease in graphene airgel, freeze-dry, and stably encapsulate TGC protease;

[0030] b. Add fatty alcohol polyoxyethylene ether and alkyl glycoside, and ultrasonically disperse evenly;

[0031] c. It is further mixed with chitosan, acrylic acid, collagen, and azone to make a jelly, which is a controlled-release scar repairing cosmetic gel material.

[0032] The freeze-drying temperature is -20°C.

[0033] The ultrasonic frequency of ultrasonic dispersion is 100kHz, and the power density is 0.8W / cm 2 , the dispersion time is 20min.

[0034] Among the raw materials, 4 parts by weight of TGC protease, 5 parts by weight of graphene airgel, 5 parts by weight of fatty alcohol polyoxyethylene ether, 4 parts by weight of alkyl glycoside, 10 parts by weight of chitosan, 12 parts by weight of acrylic acid, collagen 57 parts by weight, 3 parts by weight of azone.

Embodiment 2

[0036] a. Disperse commercially available TGC protease in graphene airgel, freeze-dry, and stably encapsulate TGC protease;

[0037] b. Add fatty alcohol polyoxyethylene ether and alkyl glycoside, and ultrasonically disperse evenly;

[0038] c. It is further mixed with chitosan, acrylic acid, collagen, and azone to make a jelly, which is a controlled-release scar repairing cosmetic gel material.

[0039] The freeze-drying temperature is -10°C.

[0040] The ultrasonic frequency of ultrasonic dispersion is 70kHz, and the power density is 0.6W / cm 2 , The dispersion time is 40min.

[0041]Among the raw materials, 2 parts by weight of TGC protease, 8 parts by weight of graphene airgel, 5 parts by weight of fatty alcohol polyoxyethylene ether, 4 parts by weight of alkyl glycoside, 5 parts by weight of chitosan, 15 parts by weight of acrylic acid, collagen 60 parts by weight, 1 part by weight of azone.

Embodiment 3

[0043] a. Disperse commercially available TGC protease in graphene airgel, freeze-dry, and stably encapsulate TGC protease;

[0044] b. Add fatty alcohol polyoxyethylene ether and alkyl glycoside, and ultrasonically disperse evenly;

[0045] c. It is further mixed with chitosan, acrylic acid, collagen, and azone to make a jelly, which is a controlled-release scar repairing cosmetic gel material.

[0046] The freeze-drying temperature is -15°C.

[0047] The ultrasonic frequency of ultrasonic dispersion is 70kHz, and the power density is 0.7W / cm 2 , The dispersion time is 30min.

[0048] Among the raw materials, 3 parts by weight of TGC protease, 7 parts by weight of graphene airgel, 5 parts by weight of fatty alcohol polyoxyethylene ether, 2 parts by weight of alkyl glycoside, 5 parts by weight of chitosan, 12 parts by weight of acrylic acid, collagen 63 parts by weight, 3 parts by weight of azone.

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Abstract

The invention discloses a controlled-release type scar repairing and beautifying gel material and a preparation method. The controlled-release type scar repairing and beautifying gel material is prepared through the following steps: a, dispersing commercially-available TGC protease into graphene aerocolloid, carrying out freeze drying, and then stably packaging the TGC protease; b, adding the TGCprotease into fatty acid-polyoxyethylene ether and alkyl glycoside, and ultrasonically and uniformly dispersing; c, mixing with chitosan, acrylic acid, collagen and azone, thus preparing a colloid, i.e., the controlled-release type scar repairing and beautifying gel material. The preparation method disclosed by the invention has the following beneficial effects that by packaging the TGC protease in the graphene aerocolloid and further utilizing the permeability of fatty acid-polyoxyethylene ether, alkyl glycoside and azone, the purposes of controllable releasing and deep in skin can be achieved during scar repairing; meanwhile, nutrition supply and nutrition regulation can be effectively carried out, a skin metabolic function can be recovered, and perfect repairing on scars, striae gravidarum, acne scars, scabies scars and the like can be realized.

Description

technical field [0001] The invention relates to the field of medical cosmetology, in particular to the preparation of a repairing gel, in particular to a controlled-release scar repairing and beautifying gel material and a preparation method. Background technique [0002] With the improvement of people's living standards, people pay more and more attention to the pursuit of external beauty, and plastic surgery and beauty are gradually becoming popular. Eliminating scars is a common problem in beauty treatment. The scars caused by acne spots on the face, long-term scabies, body sutures, caesarean section, burns, etc. have seriously affected the body image. The main cause of scars is the irregular growth and thickening of collagen fibers in the deep part of the scar, which is irregularly arranged, or wavy, or entangled into ropes. Moreover, the blood vessels and nerves inside the scar are disordered, lack of stable blood supply and activity function, and often show redness, ...

Claims

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Application Information

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IPC IPC(8): A61K38/48A61K9/06A61K47/04A61K47/10A61K47/26A61K47/22A61P17/02
CPCA61K38/48A61K9/0014A61K9/06A61K47/02A61K47/10A61K47/22A61K47/26A61P17/02
Inventor 陈庆曾军堂
Owner CHENDU NEW KELI CHEM SCI CO LTD
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