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Calcium gluconate-L-calcium lactate oral liquid and preparation method thereof

A technology of calcium lactate oral liquid and calcium gluconate, applied in the field of medicine, can solve the problems of low calcium content, low storage stability, easy crystallization and precipitation of calcium gluconate oral liquid, etc. effect of dissolution

Active Publication Date: 2018-11-23
北京华润高科天然药物有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The first problem to be solved by the present invention is that the existing calcium gluconate oral liquid has low stability and is easy to crystallize and precipitate and reduce the problem of drug efficacy. The second technical problem to be solved by the present invention is the glucose in the prior art Calcium Acid Oral Liquid contains low calcium content

Method used

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  • Calcium gluconate-L-calcium lactate oral liquid and preparation method thereof
  • Calcium gluconate-L-calcium lactate oral liquid and preparation method thereof
  • Calcium gluconate-L-calcium lactate oral liquid and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0038] (1) Quantitatively weigh 1000ml of purified water and place it in a reflux tank, heat and boil to 100°C, then continue to heat and reflux at 100°C for 30min, separate 200ml of boiled purified water for later use;

[0039] (2) Weigh 53.01g of calcium gluconate, 3.80g of lactic acid and 43.50g of L-calcium lactate, and slowly add them to the above-mentioned reflux tank successively under constant stirring, stir evenly, continue heating and reflux at 100°C for 30min, after reflux Stop heating, pass circulating water to cool down to 34°C, and prepare medicinal liquid, wherein, the content of D-calcium lactate in L-calcium lactate is 0.5wt%;

[0040] (3) Take the freshly boiled purified water separated from step (1) and stir to cool down to 60°C, add 0.24g of sucralose, stir to fully dissolve it, add it to the above-mentioned reflux tank, stir evenly, and then add to the above-mentioned reflux tank Freshly boiled purified water cooled to 37°C, dilute the solution in the refl...

Embodiment 2

[0043] (1) Quantitatively weigh 1050ml of purified water and place it in a reflux tank, heat and boil to 100°C, then continue to heat and reflux at 100°C for 50min, separate 150ml of boiled purified water for later use;

[0044] (2) Weigh 50.01g of calcium gluconate, 3.98g of lactic acid and 44.50g of L-calcium lactate, slowly add them to the above-mentioned reflux tank in turn under continuous stirring, stir evenly, continue heating and reflux at 100°C for 40min, after the reflux Stop heating, cool down to 40°C through circulating water, and prepare a medicinal solution, wherein the content of D-calcium lactate in L-calcium lactate is 1.5wt%;

[0045] (3) Take the freshly boiled purified water separated from step (1) and stir to cool down to 55°C, add 0.20 g of sucralose, stir to fully dissolve it, add it to the above-mentioned reflux tank, stir evenly, and then add to the above-mentioned reflux tank Freshly boiled purified water (30-40) cooled to 32°C, dilute the solution in...

Embodiment 3

[0048] (1) Quantitatively weigh 950ml of purified water and place it in a reflux tank, heat and boil to 100°C, then continue to heat and reflux at 100°C for 40min, separate 300ml of boiled purified water for later use;

[0049](2) Weigh 55.01g of calcium gluconate, 3.50g of lactic acid and 40.50g of L-calcium lactate, slowly add them to the above-mentioned reflux tank in turn under constant stirring, stir evenly, continue heating and reflux at 100°C for 50min, after the reflux Stop heating, pass circulating water to cool down to 40°C, and prepare medicinal solution, wherein the content of D-calcium lactate in L-calcium lactate is 1.0wt%;

[0050] (3) Take the freshly boiled purified water separated from step (1) and stir to cool down to 65°C, add 0.28g of sucralose, stir to fully dissolve it, add it to the above-mentioned reflux tank, stir evenly, and then add to the above-mentioned reflux tank Freshly boiled purified water cooled to 30°C, dilute the solution in the reflux tan...

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Abstract

The invention relates to a calcium supplementing agent, in particular to calcium gluconate-L-calcium lactate oral liquid and a preparation method thereof, and belongs to the technical field of medicine. The oral liquid is prepared from the following raw materials including 45 to 60 weight parts of calcium gluconate, 38 to 48 weight parts of L-calcium lactate, 2 to 5 weight parts of lactic acid and900 to 1100 weight parts of parts of pure water, wherein the content of D-calcium lactate in L-calcium lactate is less than or equal to 2.0 weight percent; the ingredients are mutually matched to obtain the oral liquid with high calcium content and high stability.

Description

technical field [0001] The invention relates to a calcium supplement, in particular to a calcium gluconate-L-calcium lactate oral liquid and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Calcium gluconate oral liquid is one of the most widely used calcium supplements, mainly used for the prevention and treatment of calcium deficiency, such as osteoporosis, tetany, bone hypoplasia, rickets, and calcium supplementation for pregnant and lactating women . Since the saturated solubility of calcium gluconate is only 10%, it is unstable during placement and is prone to crystallization and precipitation. In order to improve the stability of calcium gluconate, the current conventional method is to reduce the content of calcium gluconate, and the stability of placement is better at present. Calcium content in the calcium gluconate oral liquid is mostly between 2.4-5.3mg / ml, so low calcium content forces patients to take a la...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/26A61K31/191A61K31/19A61K33/06A61P3/14
CPCA61K9/0095A61K31/19A61K31/191A61K33/06A61K47/26A61P3/14A61K2300/00
Inventor 王秋平黄元红冉建明杜秀琴李建龙
Owner 北京华润高科天然药物有限公司
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