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Preparation and prescription technology for berberine hydrochloride tablet preparation

A berberine hydrochloride preparation technology, which is applied in the preparation of berberine hydrochloride tablet preparations and in the field of prescription technology, can solve the problems of poor berberine hydrochloride tablet granule formation, slow content dissolution, large tablet weight differences, etc., and achieve convenient Effects of granule fluidity, rapid dissolution of content, and reduction of tablet weight differences

Inactive Publication Date: 2018-11-23
江苏长江药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the present invention provides a preparation and prescription process of a berberine hydrochloride tablet preparation, which solves the problem of poor particle formation of berberine hydrochloride tablets, easy sticking and punching during the tableting process, large discrepancies in tablet weight, and problems in finished products. Problems of low yield and slow content dissolution

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment one: a kind of preparation and prescription technology of berberine hydrochloride tablet preparation, comprises the following steps:

[0026] S1) Sample extraction: select 0.25 parts of ethanol and 10 parts of pure water and stir evenly for 3 minutes to prepare a 70% ethanol solution as a wetting agent, select 0.20 parts of 8% starch slurry (1.6 parts of cornstarch, washed with hot water), Prepared and cooled for 3 hours as a binder; select berberine hydrochloride: 1 part, cornstarch: 0.36 part and carboxymethyl starch sodium: 0.06 part;

[0027] S2) Sample mixing and granulation: put berberine hydrochloride: 1 part, corn starch: 0.36 part and carboxymethyl starch sodium: 0.06 part selected in S1) into the high-efficiency wet granulator, start stirring at low speed for 5 minutes, and then start Stir at high speed for 5 minutes. After stirring for a total of 10 minutes, add 0.20 parts of 8% starch slurry as a binder, start the pelletizing motor, and discharge ...

Embodiment 2

[0030] Embodiment two: a kind of preparation and prescription technology of berberine hydrochloride tablet preparation, comprises the following steps:

[0031] S1) Sample extraction: select ethanol: 0.5 parts and 11 parts of pure water and stir evenly for 3.2 minutes to prepare a 70% ethanol solution as a wetting agent, select 0.9 parts of 8% starch slurry (2 parts of cornstarch, washed with hot water), Prepared and cooled for 3 hours to make a binder; select berberine hydrochloride: 2 parts, corn starch: 0.9 part and carboxymethyl starch sodium: 1 part;

[0032] S2) Sample mixing and granulation: put berberine hydrochloride: 2 parts, corn starch: 2 parts and carboxymethyl starch sodium: 0.1 part selected in S1) in the high-efficiency wet granulator, start stirring at low speed for 5 minutes, and then start Stir at high speed for 5 minutes. After stirring for a total of 10 minutes, add 3 parts of 8% starch slurry as a binder, start the pelletizing motor, and discharge the mate...

Embodiment 3

[0035] Embodiment three: the preparation of a kind of berberine hydrochloride tablet preparation and prescription technology, comprise the following steps:

[0036] S1) Sample extraction: select ethanol: 2 parts and 13 parts of pure water and stir evenly for 3.5 minutes to prepare a 70% ethanol solution as a wetting agent, select 1.8 parts of 8% starch slurry (3 parts of cornstarch, washed with hot water), Prepared and cooled for 3 hours to make a binder; select berberine hydrochloride: 4 parts, corn starch: 2 parts and carboxymethyl starch sodium: 1.5 parts;

[0037] S2) Sample mixing and granulation: put berberine hydrochloride: 4 parts, corn starch: 5 parts and carboxymethyl starch sodium: 0.5 parts selected in S1) in a high-efficiency wet granulator, start stirring at a low speed for 5 minutes, and then start Stir at high speed for 5 minutes. After stirring for a total of 10 minutes, add 5 parts of 8% starch slurry as a binder, start the pelletizing motor, and discharge th...

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Abstract

The invention discloses preparation and a prescription technology for berberine hydrochloride tablet preparation. The berberine hydrochloride tablet preparation is prepared from the following raw materials in parts by weight: 1 to 15 parts of berberine hydrochloride, 0.36 to 36 parts of corn starch, 0.06 to 6 parts of carboxymethyl starch sodium, 0.25 to 25 parts of 70% ethyl alcohol, 0.20 to 20 parts of 8% starch slurry, 0.004 to 0.40 part of magnesium stearate and 0.004 to 0.40 part of silicon dioxide. By means of the preparation of the berberine hydrochloride tablet preparation, a berberinehydrochloride tablet can be prepared. According to the prepared berberine hydrochloride tablet, carboxymethyl starch sodium is utilized for improving internal disintegration of particles, so that content dissolution is quickened, and the efficiency is improved; the amount of utilizing a 70% ethanol solution as a wetting agent is reduced; the starch slurry is added to serve as an adhesive, so thatparticle formation and particle fluidity are facilitated; silicon dioxide is added, so that the sticking phenomenon in a particle tabletting process is improved, fluidity is improved, the phenomenonthat the berberine hydrochloride tablet particles are prone to sticking in a tabletting process is solved, tablet weight difference is reduced, a finished product yield is improved, and content dissolution is quick.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the preparation and prescription process of a berberine hydrochloride tablet preparation. Background technique [0002] Berberine hydrochloride tablets are used for intestinal infection, such as gastroenteritis. Each tablet of this product contains 0.1 g of berberine hydrochloride as the main ingredient, and the auxiliary materials are starch, silicon dioxide, hypromellose, sodium starch glycolate, Magnesium Stearate, Ethanol. [0003] Today's berberine hydrochloride tablets are prone to sticking and punching during the tableting process, with large differences in tablet weight, low yield of finished products, slow content dissolution, and inconvenient granule molding. The sticking phenomenon in the process of granule tableting needs to be improved. Contents of the invention [0004] (1) Solved technical problems [0005] Aiming at the deficiencies of the prior art, the pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4375A61K47/36A61K47/04
CPCA61K9/2009A61K9/2059A61K9/2095A61K31/4375
Inventor 戴恩达刘正华
Owner 江苏长江药业有限公司
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