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Preparation method and application of PAMs (natural plant antimicrobial solution) hydrogel patch

A hydrogel patch, natural plant technology, applied in the direction of topical antibacterial agents, plant/algae/fungus/moss ingredients, antibacterial drugs, etc. and other problems, to achieve the effect of good skin adhesion, avoiding secondary damage, and not polluting clothes

Active Publication Date: 2018-11-23
云南民族医药研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the large alcohol content (about 50%) of the conventional disinfectant and antibacterial agent, it has greater irritation to the damaged skin surface (such as scalding), and there are problems that the drug has a short action time on the wound surface and the drug effect is not sufficient.

Method used

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  • Preparation method and application of PAMs (natural plant antimicrobial solution) hydrogel patch
  • Preparation method and application of PAMs (natural plant antimicrobial solution) hydrogel patch
  • Preparation method and application of PAMs (natural plant antimicrobial solution) hydrogel patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The hydrogel patch includes the following raw materials in parts by weight: 15 parts of glycerin, 2 parts of NP-700, 0.2 parts of aluminum glycolate, 13.6 parts of distilled water, 0.1 part of tartaric acid, 1.5 parts of azone, 1.5 parts of propylene glycol, 0.25 parts of SDS, and PAMs 15.85 parts;

[0046] The preparation method of hydrogel patch, comprises the following steps:

[0047] S1. Disperse NP-700 and aluminum glycolate in glycerin under stirring conditions to form phase A;

[0048] S2, dispersing tartaric acid, PAMs, azone, propylene glycol, and SDS in water under stirring conditions to form phase B;

[0049] S3, then add phase B to phase A, stir evenly, put it in an incubator, adjust the temperature to 45°C, keep it warm for 30 hours, take it out and let it stand at room temperature for 1d to obtain the hydrogel patch;

[0050] Wherein, the PAMs include safflower, rue, comfrey, echinacea, and ethanol with a mass volume ratio of 20g:10g:20g:20g:1L;

[0051...

Embodiment 2

[0056] The hydrogel patch includes the following raw materials in parts by weight: 30 parts of glycerin, 4 parts of NP-700, 0.4 parts of aluminum glycylate, 27.2 parts of distilled water, 0.2 parts of tartaric acid, 3 parts of azone, 3 parts of propylene glycol, 0.5 parts of SDS, and 31.7 parts of PAMs;

[0057] The preparation method of hydrogel patch, comprises the following steps:

[0058] S1. Disperse NP-700 and aluminum glycolate in glycerin under stirring conditions to form phase A;

[0059] S2, dispersing tartaric acid, PAMs, azone, propylene glycol, and SDS in water under stirring conditions to form phase B;

[0060] S3, then add phase B to phase A, stir evenly, place in an incubator, adjust the temperature to 50°C, keep warm for 24 hours, take it out and let it stand at room temperature for 2 days to obtain a hydrogel patch;

[0061] Wherein, the PAMs include safflower, rue, comfrey, echinacea, and ethanol with a mass volume ratio of 30g:15g:25g:30g:1L;

[0062] Th...

Embodiment 3

[0067] The hydrogel patch includes the following raw materials in parts by weight: 45 parts of glycerin, 6 parts of NP-700, 0.6 parts of aluminum glycolate, 40.7 parts of distilled water, 0.3 parts of tartaric acid, 4.5 parts of azone, 4.5 parts of propylene glycol, 0.75 parts of SDS, and PAMs 47.55 parts;

[0068] The preparation method of hydrogel patch, comprises the following steps:

[0069] S1. Disperse NP-700 and aluminum glycolate in glycerin under stirring conditions to form phase A;

[0070] S2, dispersing tartaric acid, PAMs, azone, propylene glycol, and SDS in water under stirring conditions to form phase B;

[0071] S3. Then add phase B to phase A, stir evenly, place in an incubator, adjust the temperature to 55°C, keep warm for 18 hours, take it out and let it stand for 3 days at room temperature to obtain a hydrogel patch;

[0072] Wherein, the PAMs include safflower, rue, comfrey, echinacea, and ethanol with a mass volume ratio of 40g:20g:30g:40g:1L;

[0073]...

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Abstract

The invention discloses a preparation method and application of PAMs (natural plant antimicrobial solution) hydrogel patch. The hydrogel patch is prepared from 15-45 parts by weight of glycerol, 2-6 parts by weight of NP-700, 0.2-0.6 parts by weight of dihydroxyaluminium aminoacetate, 13.6-40.7 parts by weight of distilled water, 0.1-0.3 parts by weight of tartaric acid, 1.5-4.5 parts by weight ofazone, 1.5-4.5 parts by weight of propylene glycol, 0.25-0.75 parts by weight of SDS (sodium dodecyl sulfate), and 15.85-47.55 parts by weight of PAMs. The hydrogel patch provided by the invention has the beneficial effects of good moldability, viscoelasticity, gas permeability, good peeling property from skin and good therapeutic effect on skin burns, and can prevent skin ulceration, and has good antimicrobial and anti-inflammatory effects on wounds and good repairing effects on wound surface to slow down the problem of scar residue. The hydrogel patch is obtained by one-time heat preservation crosslinking, and the operation is convenient and advantageous for large-scale production.

Description

technical field [0001] The invention relates to the technical field of preparations. More specifically, the present invention relates to the preparation method and application of natural plant antibacterial liquid PAMs hydrogel patch. Background technique [0002] Scalds are tissue injuries caused by flameless high-temperature liquids (wastewater, hot oil, molten steel), high-temperature solids (burning metal, etc.) , second degree injury, and third degree injury. Among them, first-degree burns only damage the surface layer of the skin, local mild redness, no blisters, and obvious pain, which can be cured after soaking in cold water; third-degree burns have damage to the subcutaneous tissue, fat, muscles, and bones , and be gray or reddish-brown, should immediately wrap the wound surface with gauze and send it to a doctor for treatment; second-degree burns are dermal burns, with local redness, swelling and pain, and blisters of various sizes. At present, there are many ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/06A61K47/32A61P17/02A61P31/02A61P31/04A61K35/618
CPCA61K9/06A61K35/618A61K36/286A61K36/30A61K36/534A61K36/81A61K36/899A61K47/32A61K2236/19A61P17/02A61P31/02A61P31/04A61K2300/00
Inventor 郝静杨飘向飞丹州茆灿泉李迪强周永刚
Owner 云南民族医药研究所有限公司
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