Method of preparing beta-alanine by means of microchannel reactor

A microchannel reactor, aminopropionic acid technology, applied in the preparation of cyanide reaction, chemical instruments and methods, preparation of organic compounds, etc., can solve the problems of low conversion rate of raw materials, low product yield, short reaction time, etc., To achieve the effect of improving reaction efficiency and high atom economy

Active Publication Date: 2018-11-27
ZHEJIANG NHU CO LTD +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention mainly solves the problems of long reaction time, additional use of additives, poor product selectivity, low conversion rate of raw materials and low product yield in the prior art, and provides a method for preparing β-alanine using a microchannel reactor, The method has the advantages of short reaction time, no need for additional additives, good product selectivity, and high conversion rate of raw materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Acrylic acid and ammonia water are simultaneously pumped into the mixer of the microchannel reactor by using a metering pump, and the reaction gauge pressure of the microchannel reactor is 2.3Mpa. The microchannel reactor has a straight-line channel with a tubular structure and an enhanced mixing channel with a T-shaped structure. The hydraulic diameter of the channel is 0.5mm, and the flow rate of the controlled acrylic acid is 1.0ml / min, and the flow rate of ammonia water (25wt%) is 6.1ml / min. The mixed raw materials are put into the microchannel reactor for reaction at 140° C., and the residence time of the reaction solution is 40 minutes. The temperature of the reaction product is lowered through the cooling coil to obtain the discharge liquid containing β-alanine, and the ammonia gas absorption pump is turned on to absorb the remaining ammonia gas from the reaction. The product liquid is tested by gas phase, and the conversion rate of acrylic acid is greater than...

Embodiment 2

[0032] Acrylic acid and ammonia water are simultaneously pumped into the mixer of the microchannel reactor by using a metering pump, and the reaction gauge pressure of the microchannel reactor is 2.5Mpa. The microchannel reactor has a straight-line channel with a tubular structure and an enhanced mixing channel with a T-shaped structure. The hydraulic diameter of the channel is 0.5mm, and the flow rate of the controlled acrylic acid is 1.0ml / min, and the flow rate of ammonia water (25wt%) is 11.8ml / min. The mixed raw materials are then put into the microchannel reactor for reaction at 150° C., and the residence time of the reaction solution is 60 minutes. The temperature of the reaction product is lowered through the cooling coil to obtain the discharge liquid containing β-alanine, and the ammonia gas absorption pump is turned on to absorb the remaining ammonia gas from the reaction. The product liquid is tested by gas phase, and the conversion rate of acrylic acid is greate...

Embodiment 3

[0034] Acrylic acid and ammonia water are simultaneously pumped into the mixer of the microchannel reactor by using a metering pump, and the reaction gauge pressure of the microchannel reactor is 2.5Mpa. The microchannel reactor has a straight-line channel with a tubular structure and an enhanced mixing channel with a T-shaped structure. The hydraulic diameter of the channel is 4mm, and the flow rate of the controlled acrylic acid is 1.0ml / min, and the flow rate of ammonia water (18wt%) is 12.8ml / min. min. The mixed raw materials are put into the microchannel reactor for reaction at 160° C., and the residence time of the reaction solution is 60 minutes. The temperature of the reaction product is lowered through the cooling coil to obtain the discharge liquid containing β-alanine, and the ammonia gas absorption pump is turned on to absorb the remaining ammonia gas from the reaction. The product liquid is tested by gas phase, and the conversion rate of acrylic acid is greater t...

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Abstract

The invention discloses a method of preparing beta-alanine by means of a microchannel reactor. The method comprises the steps of (1) mixing well acrylic acid and ammonia water by a premixer of the microchannel reactor, allowing the mixture to enter a thermostatic reactor of the microchannel reactor and react to obtain discharge that includes beta-alanine; (2) decoloring the discharge of the step (1), filtering, concentrating, crystallizing, and drying to obtain refined beta-alanine. The microchannel reactor is used herein as a reaction device; adding additives to inhibit side reactions is notrequired; conversion rate of the acrylic acid is higher than 99%; product yield reaches 85% and above.

Description

technical field [0001] The invention relates to a method for preparing amino acids using a microchannel reactor, in particular to a method for preparing β-alanine. Background technique [0002] β-alanine, also known as 3-alanine, is an important biological reagent and organic synthesis intermediate, mainly used in the synthesis of pantothenic acid and calcium pantothenate, carnosine, sodium pamidronate, balsalazide, etc. It can be used to prepare electroplating corrosion inhibitor, and it is widely used in medicine, feed, food and other fields. [0003] At present, the techniques for producing β-alanine mainly include acrylonitrile ammoniation method, acrylic acid (ester) ammoniation method and succinimide method. Among them, the acrylonitrile ammoniation method has a long route, accompanied by multi-step side reactions, a large amount of waste salt is produced in the hydrolysis process, and the production cost is high; the succinimide method has strict process requirements...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C227/08C07C229/08
CPCC07C227/08C07C229/08
Inventor 李博彭俊华李继涛倪海江王钰于明毛建拥
Owner ZHEJIANG NHU CO LTD
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