Biological antibacterial material for medical catheter and preparation method

An antibacterial material and biological technology, applied in the field of medical materials, can solve the problems of obvious foreign body sensation, poor biocompatibility, poor antibacterial performance, etc., to prevent foreign body sensation, improve biocompatibility, and increase self-lubricating smoothness Effect

Inactive Publication Date: 2018-12-07
CHENDU NEW KELI CHEM SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Aiming at the currently widely used medical catheter materials, there are defects such as large differences with human body tissues, poor biocompatibility, poor antibacterial performance, obvious foreign body sensation, and easy tissue infection. The present invention proposes a biological antibacterial material for medical catheters. Materials and preparation methods, thereby effectively improving the biocompatibility of materials, preventing foreign body sensation, and having self-lubricating smoothness and self-cleaning properties, avoiding the risk of tissue infection

Method used

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  • Biological antibacterial material for medical catheter and preparation method

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Effect test

Embodiment 1

[0032] The preparation process is:

[0033] (1) Mixing silicone, graphene, and medicine, so that silicone and graphene are closely combined to obtain a self-lubricating material; the medicine is a composition of antibacterial agent, analgesic, and anti-inflammatory agent; the mixing rotor speed is 46r / min, the mixing time is 16min; in the self-lubricating material, 7 parts by weight of silicone, 4 parts by weight of graphene, and 0.5 parts by weight of drug;

[0034] (2) Knead and mix soybean protein, dialdehyde polysaccharide crosslinking agent and plasticizer evenly, add the self-lubricating material prepared in step (1), then add polycaprolactone and silicone rubber, knead evenly, and extrude to make Granules, made of self-lubricating biological antibacterial material pellets; plasticizer is mannitol; silicone rubber is methyl silicone rubber; kneading fast paddle speed is 33r / min, slow paddle speed is 24r / min, kneading time is 13min The rotor speed of mixing is 69r / min, a...

Embodiment 2

[0037] The preparation process is:

[0038] (1) Mixing silicone, graphene, and medicine, so that silicone and graphene are closely combined to obtain a self-lubricating material; the medicine is a composition of antibacterial agent, analgesic, and anti-inflammatory agent; the mixing rotor speed is 42r / min, the mixing time is 16min; in the self-lubricating material, 6 parts by weight of silicone, 4 parts by weight of graphene, and 0.9 parts by weight of drug;

[0039] (2) Knead and mix soybean protein, dialdehyde polysaccharide crosslinking agent and plasticizer evenly, add the self-lubricating material prepared in step (1), then add polycaprolactone and silicone rubber, knead evenly, and extrude to make Granules, made of self-lubricating biological antibacterial material pellets; plasticizer is monoglyceride; silicone rubber is methyl vinyl silicone rubber; kneading fast paddle speed is 31r / min, slow paddle speed is 23r / min, kneading time is 13min; the rotor speed of mixing is ...

Embodiment 3

[0042] The preparation process is:

[0043] (1) Mixing silicone, graphene, and medicine, so that silicone and graphene are closely combined to obtain a self-lubricating material; the medicine is a composition of antibacterial agent, analgesic, and anti-inflammatory agent; the mixing rotor speed is 48r / min, the mixing time is 16min; in the self-lubricating material, 8 parts by weight of silicone, 5 parts by weight of graphene, and 0.8 parts by weight of drug;

[0044] (2) Knead and mix soybean protein, dialdehyde polysaccharide crosslinking agent and plasticizer evenly, add the self-lubricating material prepared in step (1), then add polycaprolactone and silicone rubber, knead evenly, and extrude to make Granules, obtained self-lubricating biological antibacterial material pellets; Plasticizer is mannitol; Silicone rubber is methyl vinyl phenyl silicone rubber; The fast paddle speed of kneading is 34r / min, and the slow paddle speed is 27r / min, The kneading time is 9min; the ro...

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Abstract

The invention provides a biological antibacterial material for a medical catheter and a preparation method. The preparation method comprises the following steps: mixing silicone with graphene and medicines to obtain self-lubricating materials; adding soybean protein, a dialdehyde polysaccharide crosslinking agent and a plasticizer into the self-lubricating materials to obtain a mixture; then adding polycaprolactone and silicon rubber into the mixture, and performing extrusion and granulation to obtain self-lubricating biological antibacterial material granules; performing heating and extrusionmolding on the granules to prepare the medical catheter and then using the medical catheter. According to the method, through compounding of the silicone, the graphene and the antibacterial medicines, the silicone and the antibacterial medicines are tightly bonded with the graphene, so that the self-lubricating smoothness and self-cleanliness of the materials are increased, the risks that the materials are adhered with tissues and inflammation syndrome is produced are effectively avoided, and meanwhile, the soybean protein is added into the polycaprolactone system, so that the biocompatibility between the materials and the tissues is promoted, and a sense of foreign materials is effectively prevented.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to the preparation of biological antibacterial materials, in particular to a biological antibacterial material used for medical catheters and a preparation method. Background technique [0002] Various types of catheters are often used in medical treatment to achieve the purpose of replacing and controlling certain functions of the human body. Such as urinary catheter, tracheal intubation, central venous catheter, PICC tube, in-tube cannula, ventricular drainage tube, three-chamber two-bag tube, closed chest drainage tube, etc. There are many kinds of medical catheter materials-there are dozens of organic polymer materials used in medical plastic products-used in products for different purposes due to their different properties. Biomedical materials-refers to a class of materials with special properties and special functions, which are used in medical and health care fields such as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/06A61L29/04A61L29/02A61L29/14A61L29/16
CPCA61L29/06A61L29/02A61L29/048A61L29/14A61L29/16A61L2300/402A61L2300/404A61L2300/41A61L2400/10C08L67/04C08L83/04C08L89/00
Inventor 陈庆曾军堂
Owner CHENDU NEW KELI CHEM SCI CO LTD
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