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Polymer loaded with penicillin and nitric oxide at same time as well as preparation method and application of polymer

A technology of nitric oxide and penicillin, which is applied in the field of biomedical engineering to achieve the effect of high density, high-efficiency loading and increasing loading

Active Publication Date: 2018-12-11
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, polymer materials and their applications that can simultaneously achieve high loading of penicillin and nitric oxide have not been reported

Method used

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  • Polymer loaded with penicillin and nitric oxide at same time as well as preparation method and application of polymer
  • Polymer loaded with penicillin and nitric oxide at same time as well as preparation method and application of polymer
  • Polymer loaded with penicillin and nitric oxide at same time as well as preparation method and application of polymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Referring to Example 4 of the Chinese publication "CN201711008528.3-a dendrimer-modified gold nanoparticle and its preparation method and application", a chitosan-grafted dendritic polyamide-amine (CS-PAMAM) was prepared.

Embodiment 2

[0051] Referring to Example 5 of the Chinese publication "CN201711008528.3-a dendrimer-modified gold nanoparticle and its preparation method and application", a chitosan-grafted dendrimer polyamide-amine (CS-PAMAM) was prepared.

Embodiment 3

[0053] Referring to Example 6 of the Chinese publication "CN201711008528.3-a dendrimer-modified gold nanoparticle and its preparation method and application", a chitosan-grafted dendritic polyamide-amine (CS-PAMAM) was prepared.

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PUM

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Abstract

The invention belongs to the field of biomedical engineering and discloses a polymer loaded with penicillin and nitric oxide at the same time as well as a preparation method and application of the polymer. The structural formula of the polymer is described in the following description. For the polymer, a dendritic cation alkynyl group-contained polyamide-amine dendritic molecule PAMAM (polyamide-amine) as an NO donor, and a dendritic structure and a great quantity of secondary amine in the structure are beneficial to efficient loading of NO; in addition, PAMAM contains a great quantity of primary amine groups at the same time, so that efficient loading of the penicillin is facilitated, and efficient loading of NO and PCN is realized; polyamide-amine is grafted with chitosan, so that the biocompatibility of a material can be greatly improved, and meanwhile, high grafting ratio of a chitosan long chain to the polyamide-amine greatly increases the loading amounts of NO and PCN; and meanwhile, the antibacterial effect of the polymer loading the penicillin and NO at the same time is better than the antibacterial effect of a polymer singly loading the penicillin or NO, and the synergistic effect is generated. (The formula is shown in the description.).

Description

technical field [0001] The invention belongs to the field of biomedical engineering, in particular to a polymer simultaneously loaded with penicillin and nitric oxide, a preparation method and application thereof. Background technique [0002] According to the 2014 CHINET China Bacterial Resistance Surveillance Report, bacterial drug resistance is still on the rise, and the emergence and increasing of multidrug-resistant, extensively drug-resistant and fully drug-resistant strains have brought challenges to anti-infective treatment. Antibiotic resistance has become a serious problem of global concern and a hot topic of scientific research. [0003] Research results in recent years have revealed that the problem of antibiotic resistance is not only related to the large number of drug-resistant strains, but also closely related to the growth of pathogenic bacteria in the form of biofilm in the human body. Biofilm is a highly structured film-like complex formed by bacteria adh...

Claims

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Application Information

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IPC IPC(8): A61K47/59A61K47/61A61K31/43A61K33/00A61P31/04
CPCA61K31/43A61K33/00A61K47/595A61K47/61A61P31/04A61K2300/00
Inventor 马栋刘施欣张武胡云峰薛巍
Owner JINAN UNIVERSITY
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