Preparation method of etodolac sustained release preparation

A technology of etodolac and sustained-release preparations, which is applied in the direction of anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc. It can solve the problems of large amount of excipients, changes in drug release, and unfavorable oral administration, etc., and achieves high production efficiency and low dosage. Moderate and good sustained-release effect

Inactive Publication Date: 2018-12-18
刘丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dosage forms produced by this technology have the risk of sudden release and changes in drug release during storage, and the amount of excipients is large, which is not conducive to oral administration

Method used

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  • Preparation method of etodolac sustained release preparation
  • Preparation method of etodolac sustained release preparation
  • Preparation method of etodolac sustained release preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1) Dissolve 100g etodolac in 140g 95% ethanol to obtain etodolac ethanol solution, which is recorded as solution A;

[0024] 2) Add 150g of hydroxypropyl β-cyclodextrin and 20g of mannitol to solution A to obtain solution B;

[0025] 3) Dissolve 150 g of polylactic acid and 20 g of polyethylene glycol 200 in 150 g of acetone to obtain a solution of polylactic acid and polyethylene glycol 200, which is recorded as solution C;

[0026] 4) Mix solution B and solution C to obtain solution D;

[0027] 5) Transfer solution D to a magnetic stirrer, control the temperature of solution D at 15℃~18℃, continuously stir solution D for 12 hours, and then reduce the temperature of solution D to 0℃~1℃ within 2 hours and let it stand for 12 Keep the temperature of solution D at 0℃~1℃ during standing;

[0028] 6) Heat the solution D obtained in step 5, and when the temperature of the solution D rises to 15°C-18°C, continue stirring for 12 hours, and control the temperature of the solution D at 1...

Embodiment 2

[0032] 1) Dissolve 100 g etodolac in 150 g 95% ethanol to obtain etodolac ethanol solution, which is recorded as solution A;

[0033] 2) Add 160g of hydroxypropyl β-cyclodextrin and 25g of mannitol to solution A to obtain solution B;

[0034] 3) Dissolve 160 g of polylactic acid and 30 g of polyethylene glycol 200 in 160 g of acetone to obtain a solution of polylactic acid and polyethylene glycol 200, which is recorded as solution C;

[0035] 4) Mix solution B and solution C to obtain solution D;

[0036] 5) Transfer solution D to a magnetic stirrer, control the temperature of solution D at 15℃~18℃, continuously stir solution D for 12 hours, and then reduce the temperature of solution D to 0℃~1℃ within 2 hours and let it stand for 12 Keep the temperature of solution D at 0℃~1℃ during standing;

[0037] 6) Heat the solution D obtained in step 5, and when the temperature of the solution D rises to 15°C-18°C, continue stirring for 12 hours, and control the temperature of the solution D at...

Embodiment 3

[0041] 1) Dissolve 100g etodolac in 160g 95% ethanol to obtain etodolac ethanol solution, which is recorded as solution A;

[0042] 2) Add 170g of hydroxypropyl β-cyclodextrin and 30g of mannitol to solution A to obtain solution B;

[0043] 3) Dissolve 170 g of polylactic acid and 40 g of polyethylene glycol 200 in 170 g of acetone to obtain a solution of polylactic acid and polyethylene glycol 200, which is recorded as solution C;

[0044] 4) Mix solution B and solution C to obtain solution D;

[0045] 5) Transfer solution D to a magnetic stirrer, control the temperature of solution D at 15℃~18℃, continuously stir solution D for 12 hours, and then reduce the temperature of solution D to 0℃~1℃ within 2 hours and let it stand for 12 Keep the temperature of solution D at 0℃~1℃ during standing;

[0046] 6) Heat the solution D obtained in step 5, and when the temperature of the solution D rises to 15°C-18°C, continuously stir for 12 hours, and the temperature of the solution D is controlle...

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Abstract

The invention provides a preparation method of an etodolac sustained release preparation. The preparation method is characterized in that the etodolac is dissolved in 95% ethanol to obtain a solutionA, and hydroxypropyl beta-cyclodextrin and mannitol are added in the solution A to obtain a solution B; polylactic acid and polyethylene glycol 200 are dissolved in acetone to obtain a solution C, thesolution B and the solution C are mixed to obtain a solution D, the solution D is transferred to a magnetic stirrer, the solution D is continuously stirred for 12 hours, the temperature of the solution D is lowered to 0 DEG C to 1 DEG C in 2 hours and the solution D is subjected to standing for 12 hours, and the temperature of the solution D is kept to 0 DEG C to 1 DEG C during a standing period;after standing for 12 hours, the solution D is heated, when the temperature of the solution D is increased to 15 DEG C to 18 DEG C, the solution D is continuously stirred, when the temperature of thesolution D is controlled at 15 DEG C to 18 DEG C while stirring, after the material is continuously stirred for 12 hours, the etodolac sustained release preparation is prepared by a low-temperature spray-drying method. The dosage of a capsule material is moderate, the drying temperature of the material is low, the obtained drug-loading preparation is uniform, the drug release is stable, and the etodolac sustained release preparation has sustained release characteristics.

Description

Technical field: [0001] The invention relates to a pharmaceutical preparation of a drug-carrying polymer preparation, in particular to a preparation method of etodolac acid sustained-release preparation. Background technique: [0002] Hydroxypropyl β-cyclodextrin is an ideal injection solubilizer and pharmaceutical excipient in the pharmaceutical industry. It can improve the water solubility of poorly soluble drugs, increase drug stability, improve drug bioavailability, increase the efficacy of the drug or reduce the dosage, adjust or control the release rate of the drug, and reduce the toxic side effects of the drug. It can be used for oral drugs, injections, mucosal drug delivery systems (including nasal mucosa, rectum, cornea, etc.), transdermal absorption drug delivery systems, and lipophilic targeted drug carriers. [0003] Polylactic acid is highly safe to the human body, has good biocompatibility and biodegradability, and is widely used in drug delivery. At present, the pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/407A61K47/10A61K47/34A61K47/40A61P29/00A61P19/02
CPCA61K31/407A61K9/5031A61K9/5036
Inventor 刘丽
Owner 刘丽
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