Modified hyaluronic acid injectable filling material and preparation method thereof

A filling material, hyaluronic acid technology, applied in pharmaceutical formulations, pharmaceutical sciences, prostheses, etc., can solve the problems of non-disclosure, and achieve the effects of good stability, good biocompatibility, and stable metabolism

Active Publication Date: 2018-12-18
福建拓烯新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In the prior art, there is no document disclosing that hyaluronic acid and polyethylene glycol are bonded through ester bonds to form a gel and applied to subcutaneous filling materials

Method used

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  • Modified hyaluronic acid injectable filling material and preparation method thereof
  • Modified hyaluronic acid injectable filling material and preparation method thereof
  • Modified hyaluronic acid injectable filling material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Step (1) Preparation of cross-linked hyaluronic acid gel:

[0040] a. Weigh hyaluronic acid / polyethylene glycol / HOBc / EDC (hyaluronic acid / polyethylene glycol / HOBt / EDC=1g / 0.5g / 0.1 / 0.1,w / w) according to a certain ratio, and dissolve them in 50mL deionized Stir well in water to make it evenly mixed;

[0041] b. Add NaH to the reaction system 2 PO 4 -NaHPO 4 , control the pH value of the reaction system=5,;

[0042] c. Control the reaction temperature to 60-80°C and stir thoroughly for 12 hours;

[0043] d. Dialyzing the reaction product to obtain a cross-linked hyaluronic acid gel.

[0044] Step (2): Weigh free transparent hyaluronic acid gel aqueous solution (molecular weight: 50KDa) according to the proportion (free transparent hyaluronic acid gel: cross-linked hyaluronic acid gel = 0.8g / 1g, w / w), and add to the solution prepared in step (1). Preparation of the prepared cross-linked hyaluronic acid gel, and fully mixing and stirring at room temperature;

[0045] S...

Embodiment 2

[0048] Step (1) Preparation of cross-linked hyaluronic acid gel:

[0049] a. Weigh hyaluronic acid / polyethylene glycol / HOBc / EDC (hyaluronic acid / polyethylene glycol / HOBt / EDC=1g / 1g / 0.1 / 0.1,w / w) according to a certain ratio, and dissolve them in 50mL deionized water Stir well to make it evenly mixed;

[0050] b. Add NaH to the reaction system 2 PO4 -NaHPO 4 , control the pH value of the reaction system=5,;

[0051] c. Control the reaction temperature to 60-80°C and stir thoroughly for 12 hours;

[0052] d. Dialyzing the reaction product to obtain a cross-linked hyaluronic acid gel.

[0053] Step (2): Weigh the free transparent hyaluronic acid gel aqueous solution (molecular weight is 50KDa) according to the proportion (free transparent hyaluronic acid gel: cross-linked hyaluronic acid gel = 0.5g / 1g, w / w), add to step (1) Preparation of the prepared cross-linked hyaluronic acid gel, and fully mixing and stirring at room temperature;

[0054] Step (3): Weigh water-soluble vi...

Embodiment 3

[0057] Step (1) Preparation of cross-linked hyaluronic acid gel:

[0058] a. Weigh hyaluronic acid / polyethylene glycol / HOBc / EDC (hyaluronic acid / polyethylene glycol / HOBt / EDC=0.5g / 1 / 0.1 / 0.1,w / w) according to a certain ratio, and dissolve them in 50mL deionized Stir well in water to make it evenly mixed; b. Add NaH to the reaction system 2 PO 4 -NaHPO 4 , control the pH value of the reaction system=5;

[0059] c. Control the reaction temperature to 60-80°C and stir thoroughly for 12 hours;

[0060] d. Dialyzing the reaction product to obtain a cross-linked hyaluronic acid gel.

[0061] Step (2): Weigh the free transparent hyaluronic acid gel aqueous solution (molecular weight is 50KDa) according to the proportion (free transparent hyaluronic acid gel: cross-linked hyaluronic acid gel = 0.5g / 1g, w / w), add to step (1) Preparation of the prepared cross-linked hyaluronic acid gel, and fully mixing and stirring at room temperature;

[0062] Step (3): Weigh water-soluble vitamin...

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Abstract

The invention discloses a modified hyaluronic acid injectable filling material and a preparation method thereof. The modified hyaluronic acid injectable filling material comprisesis prepared from freehyaluronic acidgel, cross-linked hyaluronic acid gel, water soluble cellulose and a buffering solution, wherein the hyaluronic-polyethylene glycol modifying material has the following structure: (shown in the description), wherein n is selected from 10 to 5000, and m is selected from 100 to 5000. The modified hyaluronic acid injectable filling material is good in injectability, stability and biological compatibility, applicable to soft tissue filling, restoration and surgical operation such as wrinkle removal, rhinoplastynose re-shaping and breast implanting, and also applicable to the anti-adhesion of the medical surgical operation and lubrication of bone joints.

Description

technical field [0001] The invention relates to the cosmetic field, in particular to the field of a modified hyaluronic acid injectable filling material crosslinked by polyethylene glycol. Background technique [0002] Hyaluronic acid (hyaluronic acid) is a kind of linear polymer polysaccharide composed of disaccharide units (glucuronic acid-N-ethylthioglucosamine) widely present in humans and animals. Its structural formula is: [0003] [0004] Widely present in the connective tissue, mucus tissue and bacterial capsule of vertebrates, and also in high content in the epidermis, dermis, umbilical cord, joint bone fluid and cartilage tissue. Since Meyer in the United States first isolated hyaluronic acid from the vitreous body of the bull's eye in 1934, it has gradually been discovered by the people to have important properties such as good biocompatibility, high viscoelasticity, plasticity and permeability. Therefore, it has been widely used in the fields of medical trea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/20A61L27/50A61L27/52A61L31/04A61L31/06A61L31/14
CPCA61L27/18A61L27/20A61L27/50A61L27/52A61L31/042A61L31/06A61L31/14A61L31/145A61L2400/06A61L2400/10A61L2430/34C08L5/08C08L71/02
Inventor 翁松青
Owner 福建拓烯新材料科技有限公司
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