Method for preparation of core-shell structure microcapsule based on gel network limited anti-solvent technique

A core-shell structure and gel network technology is applied in the field of core-shell structure microcapsule preparation, and the method is simple and easy to implement.

Inactive Publication Date: 2018-12-18
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, researchers at home and abroad mainly use single hydrophilic, hydrophobic and amphiphilic materials as wall materials

Method used

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  • Method for preparation of core-shell structure microcapsule based on gel network limited anti-solvent technique
  • Method for preparation of core-shell structure microcapsule based on gel network limited anti-solvent technique
  • Method for preparation of core-shell structure microcapsule based on gel network limited anti-solvent technique

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Embodiment 1

[0043] The present invention is suitable for sodium alginate samples of various molecular weights capable of forming gels, and a method for preparing a hydrophilic-hydrophobic core-shell microcapsule with sodium alginate as a nucleus, comprising the following steps:

[0044] (1) Preparation of hydrophilic nucleosomes: 50 g (3% w / w) of sodium alginate solution containing 50 mmol / L calcium carbonate was prepared with deionized water. The prepared sodium alginate solution was mixed with MCT containing 2% (w / w) lecithin according to the mass ratio of 1:4. By controlling stirring rate (600r / min, 800r / min, 10000r / min) and stirring time (1h, 1h, 5min) to regulate and control the particle size of emulsion, the MCT (20% emulsion gross mass) that will contain 0.45mol / L glacial acetic acid afterwards Drop into the emulsion and stir at 60r / min for 15min to solidify the emulsion particles. In this way, hydrophilic gel cores of various particle sizes can be prepared, such as figure 1 The ...

Embodiment 2

[0050] A kind of preparation that takes agar as the hydrophilic-hydrophobic core-shell structure microcapsule of core body, comprises the steps:

[0051] (1) Preparation of hydrophilic nucleosomes: prepare 50 g (0.5% w / w) of agar solution with deionized water, and mix the prepared agar solution with 2% (w / w) lecithin in a mass ratio of 1:4 MCT blend. Control the particle size of the emulsion by controlling the stirring rate (200r / min, 500r / min, 1000r / min) and stirring time (30min) in a 60°C water bath, then take it out and immediately place it in 4°C ice water and stir at 60r / min After 15 minutes, the emulsion particles were solidified. In this way, hydrophilic gel cores with different particle sizes can be prepared, such as figure 1 The first sheet in the second row in the middle is the optical microscope picture of the agar gel particle nuclei prepared at 200r / min.

[0052] 2)) Preparation of hydrophilic-hydrophobic core-shell microcapsules: prepare 1%-3% (w / w) zein in 70...

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Abstract

Belonging to the technical field of microcapsule preparation, the invention discloses a method for preparation of a core-shell structure microcapsule based on gel network limited anti-solvent technique. The method adopts lecithin as the emulsifier, takes sodium alginate or agar or k-carrageenan as the disperse phase, employs medium chain triglyceride as the water-in-oil emulsion of a continuous phase, ion or temperature variation is utilized to solidify the disperse phase into gel particles, then an emulsion containing solidified gel particles is added into an alcohol soluble zein solution, based on the elasticity of the gel network and the balance of osmotic pressure, water in the gel particles exudes slowly as an anti-solvent to lower the alcohol concentration of the zein solution, thusprecipitating zein dissolved in alcohol out, self-assembly occurs on the surfaces of gel particles to form a shell, and finally the core-shell structure microcapsule adopting zein as the shell and taking the gel particles as the core can be formed finally. The materials used by the method provided by the invention are all natural and edible materials, the preparation method is simple, and the formed core-shell structure microcapsule can be used for storage of easily oxidizable and deliquescent substances and slow release of flavor substances and drugs.

Description

technical field [0001] The invention relates to the technical field of preparation of core-shell structure microcapsules, in particular to a preparation method of hydrophilic-hydrophobic core-shell structure microcapsules based on gel network limited anti-solvent. Background technique [0002] The properties of the microcapsule wall material are closely related to its storage, stability, and controlled release properties, and are the key factors determining its functional properties. Microcapsules with different coating structures are formed according to the microcapsule preparation process, the properties of the core material and the wall material. In the process of food processing, the selection of microcapsule wall materials usually needs to consider the affinity and hydrophobicity of the core material. For example, when the core material is an oil-soluble substance, it is advisable to use hydrophilic or amphiphilic wall materials such as sodium alginate, gum arabic, gel...

Claims

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Application Information

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IPC IPC(8): B01J13/02
CPCB01J13/02
Inventor 方亚鹏胡冰麻瑞祥韩玲钰
Owner HUBEI UNIV OF TECH
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