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Preparation method of nano silicon dioxide/ferroferric oxide magnetic radiographic particle enhanced biological magnesium-based composite material

A nano-silicon dioxide and iron tetroxide technology, used in medical science, surgery, etc., can solve the problems of poor targeting and positioning ability, low forming ability, etc., to improve the strength and toughness, improve the degree of bonding, and greatly improve the performance. Effect

Active Publication Date: 2018-12-25
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The present invention aims to solve the technical problems of poor targeting ability and low forming ability of existing biomedical magnesium-based composite materials, and provides a nano-silicon dioxide / ferric oxide magnetic contrast particle-enhanced bio-magnesium-based composite material preparation method

Method used

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  • Preparation method of nano silicon dioxide/ferroferric oxide magnetic radiographic particle enhanced biological magnesium-based composite material
  • Preparation method of nano silicon dioxide/ferroferric oxide magnetic radiographic particle enhanced biological magnesium-based composite material
  • Preparation method of nano silicon dioxide/ferroferric oxide magnetic radiographic particle enhanced biological magnesium-based composite material

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specific Embodiment approach 1

[0028] Specific implementation mode 1: This implementation mode is a preparation method of nano-silica / ferric iron tetroxide magnetic contrast particle-enhanced bio-magnesium-based composite material, which is specifically carried out according to the following steps:

[0029] 1. Preparation of nano-silica / ferroferric oxide magnetic contrast particle combination: mix nano-silica hollow microspheres with ferroferric oxide magnetic nanoparticles at a temperature of 250°C to 400°C by high-temperature ball milling, Then carry out hot pressing, and naturally cool to room temperature to obtain nano silicon dioxide / ferric oxide magnetic contrast particle combination;

[0030] The mass ratio of the nano-silica hollow microspheres to the ferroferric oxide magnetic nanoparticles is 1:(1.8~3);

[0031] The ball milling time of the high temperature ball milling is 0.5h~1.5h, and the ball milling speed is 250r / min~400r / min;

[0032] The temperature of the hot pressing is 250°C-400°C, the ...

specific Embodiment approach 2

[0040] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the particle diameter of the nano-silica hollow microspheres described in step one is 40nm~100nm, the aperture is 15nm~35nm, and the porosity is 85%~ 100%. Others are the same as the first embodiment.

specific Embodiment approach 3

[0041] Embodiment 3: This embodiment differs from Embodiment 1 or Embodiment 2 in that: the particle size of the ferroferromagnetic nanoparticles described in step 1 is 30nm-100nm. Others are the same as those in Embodiment 1 or 2.

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Abstract

The invention discloses a preparation method of a nano silicon dioxide / ferroferric oxide magnetic radiographic particle enhanced biological magnesium-based composite material and relates to a preparation method of a magnesium-based composite material. The preparation method solves the technical problem that an existing biomedical magnesium-based composite material is relatively poor in targeting and positioning ability and low in forming ability. The preparation method comprises the following steps: I, preparing a nano magnetic radiographic particle coalition; and II, carrying out ultrasonic coupling, stirring and self-regulating treatment and graded temperature-changing infiltrating and hot press molding. The interfacial activity of nano silicon dioxide hollow microspheres and ferroferricoxide magnetic particles are improved favorably by means of high-temperature mechanical ball milling, inclusion of a magnesium liquid can be reduced by means of ultrasonic coupling, stirring and self-regulating treatment, the tissue uniformity is improved, and the target positioning ability is improved. The infiltration ability can be further improved by means of graded temperature-changing hot pressing, and the casting defects are reduced and the crystal grains are refined. Under the action of ultrasonic coupling, stirring and self-regulating treatment and graded temperature-changing infiltrating and hot press molding, the strength and toughness of the magnesium-based composite material can be improved obviously.

Description

technical field [0001] The invention relates to a preparation method of biological magnesium-based composite material. Background technique [0002] Metal stents have achieved remarkable curative effects after clinical treatment, but they are prone to thrombosis, high restenosis rate, and damage to the vessel wall. Magnesium-based alloys are degradable, have good vascular support, and can effectively reduce stent restenosis, so they have received widespread attention. However, traditional magnesium-based alloys cannot achieve effective diagnosis and real-time monitoring of living tissue diseases, and have low strength and poor plasticity. [0003] In view of the above problems, mesoporous nano-biomaterials can be used as imaging particles to replace the easy-to-displace The gas microbubble contrast agent, which dissolves and ruptures in the blood, and whose particle size is difficult to control, is expected to play an important role in the diagnosis and treatment of major ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C23/00C22C23/04C22C32/00C22C1/10A61L31/02A61L31/18
CPCA61L31/022A61L31/18C22C1/1015C22C1/1036C22C23/00C22C23/04C22C32/0036C22C1/1073C22C1/12
Inventor 聂凯波朱智浩邓坤坤韩俊刚杨安
Owner TAIYUAN UNIV OF TECH
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