Silk fibroin three-dimensional porous scaffold and preparation method thereof

A three-dimensional porous, silk fibroin technology, applied in medical science, prosthesis, etc., can solve the problems of inability to transport and absorb nutrients, poor water absorption and water retention performance of gel film, poor processability, etc., and achieve good biocompatibility. high water absorption, excellent mechanical properties
CN109096501AActive Publication Date: 2018-12-28WUHAN TEXTILE UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WUHAN TEXTILE UNIV
Publication Date
2018-12-28

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Abstract

The invention relates to a preparation method for a silk fibroin three-dimensional porous scaffold and the silk fibroin three-dimensional porous scaffold prepared from the method. The preparation method comprises the following steps of preparing silk fibroin by degumming silk fibers; and dissolving the silk fibroin in a salt-acid binary solution and standing to obtain a silk fibroin solution, adding polysaccharides for dissolution and standing to obtain a silk fibroin and polysaccharide blending solution; preparing a silk fibroin hydrogel by dialysis of the blending solution; and freeze-dryingthe hydrogel to obtain the silk fibroin three-dimensional porous scaffold. The method is simple to operate, a process is short, the pore diameter of the prepared scaffold is adjustable, the scaffoldhas good mechanical properties and hydroscopicity, and a series of alternative materials can be provided for the field of biomedical materials.
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Description

technical field

[0001] The invention relates to the technical field of biomaterials, in particular to a silk fibroin three-dimensional porous scaffold and a preparation method thereof. Background technique

[0002] At present, hydrogel has become an important carrier in the fields of biomaterials, biomedicine and structural biology. Traditionally, although double-network hydrogels, nanocomposite hydrogels, and topological hydrogels have excellent mechanical properties, most of them require complex synthesis, assembly, and cross-linking processes, which are long and unavoidable. Use of toxic solvents and reduction in overall performance. For example, most synthetic hydrogels have poor biocompatibility, and their degradation products are potentially toxic during the degradation process, which restricts the application of most synthetic hydrogels in the field of biomedicine.

[0003] Silk fibroin protein is an important resource with Chinese characteristics and advantages. It...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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