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Preparation method of magnesium alloy surface hydroxyapatite composite coating

A technology of hydroxyapatite and composite coating, which is applied in the field of composite materials and biomedical materials, can solve the problems of hydroxyapatite easy to agglomerate, affect biological characteristics, and not suitable for large-scale applications, so as to improve biocompatibility Sexuality and the effect of inducing new bone growth

Inactive Publication Date: 2019-01-11
长沙瑞联材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, unmodified hydroxyapatite is easy to agglomerate, and the modified hydroxyapatite may affect its biological characteristics, or the modification method is complicated, which is not suitable for large-scale application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Step 1, preparation of hydroxyapatite dispersion

[0022] 1. Prepare 0.5mol / L calcium nitrate solution, 0.2mol / L sodium dihydrogen phosphate solution, and 0.3mol / L disodium hydrogen phosphate solution, mix the sodium dihydrogen phosphate solution and disodium hydrogen phosphate solution in equal volumes, Slowly add calcium nitrate solution equal in volume to the obtained mixed solution, react in a water bath at 120°C for 4 hours, then cool down to room temperature, let stand for 10 hours, filter and wash to obtain hydroxyapatite;

[0023] 2. Suspend and disperse the hydroxyapatite in step 1 in water, add 25 mg / ml of dopamine, adjust the pH to 9, and stir for 30 hours in the dark, then centrifuge, wash with deionized water, and disperse in deionized water under the action of ultrasound , to obtain polydopamine-modified hydroxyapatite dispersion.

[0024] Step 2. Composite coating preparation

[0025] After polishing the magnesium alloy with 200 mesh, 360 mesh, 400 mesh...

Embodiment 2

[0027] 1. Prepare 1mol / L calcium nitrate solution, 0.3mol / L sodium dihydrogen phosphate solution, 0.3mol / L disodium hydrogen phosphate solution, mix the sodium dihydrogen phosphate solution and disodium hydrogen phosphate solution in equal volumes, slowly Add calcium nitrate solution equal to the volume of the obtained mixed solution, react in a water bath at 130°C for 4 hours, then cool down to room temperature, let stand for 10 hours, filter and wash to obtain hydroxyapatite;

[0028] 2. Suspend and disperse the hydroxyapatite in step 1 in water, add 40 mg / ml of dopamine, adjust the pH to 9, and stir for 30 hours in the dark, then centrifuge, wash with deionized water, and disperse in deionized water under the action of ultrasound , to obtain polydopamine-modified hydroxyapatite dispersion.

[0029] Step 2. Composite coating preparation

[0030] After polishing the magnesium alloy with 200 mesh, 360 mesh, 400 mesh, 600 mesh, 800 mesh, 1000 mesh and 1500 mesh sandpaper in se...

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PUM

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Abstract

The invention discloses a preparation method of a magnesium alloy surface hydroxyapatite composite coating. The preparation method comprises the steps that the magnesium alloy surface is subjected togrinding, polishing and micro-arc oxidation treatment in sequence, soaked in polydopamine-modified hydroxyapatite dispersion liquid, subjected to heat preservation at 100-120 DEG C for 0.5-1h and taken out, the surface is cleaned with distilled water, dried and soaked in the polydopamine-modified hydroxyapatite dispersion liquid again, the operation is repeated for 3-5 times, and the hydroxyapatite composite coating is formed on the magnesium alloy surface. Since micro-arc oxidation treatment is carried out on the magnesium alloy surface with no oxidation layer, the hydroxyapatite composite coating with the good interface binding performance is formed on the outer surface of the polydopamine-modified hydroxyapatite, and the corrosion resistance and tissue compatibility of magnesium alloy are improved.

Description

technical field [0001] The invention relates to the technical field of composite materials, in particular to a method for preparing a hydroxyapatite composite coating on the surface of a magnesium alloy, and the obtained material can be used in the field of biomedical materials. Background technique [0002] The density and Young's modulus of magnesium alloys are the closest to those of human bones. Magnesium is an essential mineral for the human body and plays an important role in the metabolic process. Its degradation products are non-toxic to the human body and can be excreted through body fluids. Therefore, the medical community recognizes that magnesium and its alloys have good application prospects in the field of degradable biomedical materials. However, the corrosion and degradation rate of magnesium alloy is too fast in the human physiological environment, and the osteoinductivity is poor, which makes it difficult to match the tissue healing speed. Therefore, surfac...

Claims

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Application Information

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IPC IPC(8): C25D11/30C25D5/42C25F3/18A61L27/04A61L27/32A61L27/34A61L27/50
CPCC25D11/30A61L27/047A61L27/32A61L27/34A61L27/50A61L2300/412A61L2400/18A61L2420/02A61L2420/04C25D5/42C25F3/18C08L79/02
Inventor 张斌罗伶平
Owner 长沙瑞联材料科技有限公司
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