Spiramycin dry suspension and preparation method thereof

A technology of spiramycin and dry suspension, which is applied in the directions of antifungal agents, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of small scope of applicable people, etc., and achieve the effect of solving bitterness and gritty feeling

Inactive Publication Date: 2019-01-15
WUXI FORTUNE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to disclose a kind of spiramycin dry suspension and its preparation method, solve the problem that the existing dosage forms are applicable to a small range of people, and effectively cover up the bitter taste of the medicine when it is taken after brewing.

Method used

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  • Spiramycin dry suspension and preparation method thereof
  • Spiramycin dry suspension and preparation method thereof
  • Spiramycin dry suspension and preparation method thereof

Examples

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Effect test

Embodiment 1

[0029] This embodiment discloses a kind of preparation method of spiramycin dry suspension:

[0030] A dry suspension of spiramycin consists of the following components:

[0031] 40-70 parts by weight of spiramycin, 10-25 parts by weight of lactose, 8-15 parts by weight of microcrystalline cellulose, 3-6 parts by weight of povidone, 2-5 parts by weight of colloidal silicon dioxide, magnesium stearate 2-5 parts by weight, 10-20 parts by weight of Eudragit, 2-5 parts by weight of stearic acid, 2-4 parts by weight of gum arabic, and 0.5-1 parts by weight of acesulfame potassium.

[0032] Prepared as follows:

[0033] (1) Place spiramycin, lactose, microcrystalline cellulose and colloidal silicon dioxide in a wet granulator and mix evenly, make a soft material with a 20% weight concentration of povidone aqueous solution, and place the soft material in an extrusion Extrude and spheronize in a spheronizer, dry the granules at 50°C, and take 60-80 mesh granules to obtain spiramycin...

Embodiment 2

[0037] This embodiment discloses the preparation method of another kind of spiramycin dry suspension:

[0038] A dry suspension of spiramycin consists of the following components:

[0039] 40-70 parts by weight of spiramycin, 10-25 parts by weight of lactose, 8-15 parts by weight of microcrystalline cellulose, 3-6 parts by weight of hydroxypropyl cellulose, 2-5 parts by weight of silicon dioxide, 2- 5 parts by weight, Eudragit 10-20 parts by weight, sodium lauryl sulfate 2-5 parts by weight, xanthan gum 2-4 parts by weight, sodium saccharin 0.5-1 parts by weight.

[0040] Prepared as follows:

[0041] (1) Put spiramycin, lactose, microcrystalline cellulose and silicon dioxide in a wet granulator and mix evenly, use 10% weight concentration of hydroxypropyl cellulose aqueous solution to make soft materials, and place the soft materials in extrusion Extrude and spheronize in a spheronizer, dry the granules at 60°C, and take 60-80 mesh granules to obtain spiramycin granules;

...

Embodiment 3

[0045] This embodiment discloses the preparation method of another kind of spiramycin dry suspension:

[0046] A dry suspension of spiramycin consists of the following components:

[0047] 40-70 parts by weight of spiramycin, 10-25 parts by weight of lactose, 8-15 parts by weight of microcrystalline cellulose, 3-6 parts by weight of ethyl cellulose suspension, 2-5 parts by weight of colloidal silicon dioxide, 2-5 parts by weight of talcum powder, 10-20 parts by weight of Eudragit, 2-5 parts by weight of sodium lauryl sulfate, 2-4 parts by weight of hydroxypropyl cellulose, and 0.5-1 part by weight of cyclamate.

[0048] Prepared as follows:

[0049] (1) Place spiramycin, lactose, microcrystalline cellulose and colloidal silicon dioxide in a wet granulator and mix them evenly, and use 15% weight concentration of ethyl cellulose suspension aqueous solution to make soft material, soft material Put it in an extrusion spheronizer, extrude and spheronize, dry the granules at 55°C,...

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Abstract

The invention discloses a spiramycin dry suspension and a preparation method thereof, which is composed of the following components: spiramycin 40-70 parts by weight, lactose 10-25 part by weight of microcrystalline cellulose 8-15 part by weight of adhesive 3-6 part by weight of fluidizing agent 2-5 part by weight of lubricant 2-5 parts by weight, Uttach 10-20 part by weight of surfactant 2-5 partby weight of suspending agent 2-4 part by weight and 0.5 part by weight of sweetener. 1 part by weight; The invention selects suitable auxiliary materials and adjusts the proportion of each componentto prepare the spiramycin granule which meets the requirements, and collocates the suitable aqueous coating solution to coat to prepare the spiramycin coating granule, finally adds a certain proportion of suspending agent, and the sweetener is mixed together to obtain the spiramycin dry suspension. The present invention makes up for the shortcomings of the prior preparation, effectively solves the bitterness and gravel feeling in the taste when taking, and is easy to be taken by the elderly and children patients, especially the patients who are difficult to swallow.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a spiramycin dry suspension and a preparation method thereof. Background technique [0002] Spiramycin is a macrolide antibiotic, its properties are white or slightly yellow powder, slightly hygroscopic, and it tastes extremely bitter when dissolved in water. Spiramycin is the acetate of acetylspiramycin, which shows strong antibacterial effect after oral administration. This product has strong antibacterial effect in vivo and post-antibacterial effect (PAE), can enhance the phagocytosis of phagocytes, is widely distributed in the body, has a higher concentration in tissue cells than erythromycin, and has less side effects than erythromycin. [0003] In recent years, the main dosage forms of spiramycin are tablets and capsules. These preparations will bring great inconvenience to the elderly and children, especially those who are difficult to swallow. After being made into a d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/32A61K47/38A61K31/7048A61P31/04A61P31/10
CPCA61K9/0095A61K9/5026A61K31/7048A61K47/38A61P31/04A61P31/10
Inventor 李标有张峰韩小霜郁晨燕薛丹露张亚伦
Owner WUXI FORTUNE PHARMA
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