Cordyceps sobolifera active substance and use thereof for preventing, delaying or treating cataract

A kind of active substance, cataract technology, applied in the field of cicada flower liquid fermentation mycelium active substance, and its pharmaceutical composition field

Inactive Publication Date: 2019-01-15
GRAPE KING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, hyaluronic acid is used to protect the corneal endothelial layer in cataract surgery, but there is no literature that clearly states that hyaluronic acid has preventive, delay or therapeutic effects on cataract
Because the cost of intraocular lenses is not affordable for people in all regions of the world, there are still risks of surgical side effects and complications

Method used

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  • Cordyceps sobolifera active substance and use thereof for preventing, delaying or treating cataract
  • Cordyceps sobolifera active substance and use thereof for preventing, delaying or treating cataract
  • Cordyceps sobolifera active substance and use thereof for preventing, delaying or treating cataract

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0047] 6. Preparation of health food containing cicadae active substance:

[0048] Those with ordinary knowledge in the technical field can use the cicada flower active substance of the present invention, the cicada flower liquid culture fermentation product containing the cicada flower active substance, the cicada flower freeze-dried product containing the cicada flower active substance or The cicadae flower water extract or cicadae flower alcohol extract that contains cicadae flower active substance, and food-grade additive (such as bulking agent, coloring agent, sweetener, spices, preservative etc.) are prepared for preventing or delaying Health food for cataract.

[0049] (2) Animal experiments:

[0050] Ultraviolet rays are classified into UVA (315-380nm), UVB (280-315nm) and UVC (100-280nm) according to their wavelength bands. Excessive exposure to ultraviolet rays will cause photochemical damage, especially UVB damage to the eyeball is the most obvious.

[0051] The ...

Embodiment 1

[0054] Embodiment one, the preparation of cicada flower liquid state fermentation culture and active substance

[0055] 1. Plate culture: Aseptically inoculate the mycelia of cicadae on a potato dextrose agar (PDA) plate medium, and culture at 25° C. for about 5 days.

[0056] 2. Flask culture: scrape the cicadae mycelium on the plate culture medium with aseptic technique and inoculate the culture medium in the flask (containing sucrose 2.0% by weight, yeast extract 0.5% by weight, soybean powder 1.0% by weight, Water was added to 100% by weight), and cultured with shaking at 25° C., pH 4.5, and 120 rpm for three days.

[0057] 3. Fermentation tank cultivation: the cicadae mycelium in the flask is aseptically inoculated in the culture medium of the fermentation tank. The composition of the medium in the fermenter was the same as that in the flask. At 25°C, 0.5-1.0kg / cm 2 Tank pressure, pH 4.5, 10rpm~150rpm stirring speed or non-stirring (air lift) and gas with 0.5-1.0VVM ae...

Embodiment 2

[0060] Example 2. Cataract Animal Model and Analysis of Related Indicators

[0061] 1. Establishment of cataract mouse animal model:

[0062] This example uses ICR strain, 6-week-old, 25-33 g female mice (purchased from Taiwan Lesco Biotechnology Co., Ltd.), which were raised in the Experimental Animal Center of Zhongshan Medical University, Taichung, Taiwan, and provided with normal clean feed and Drinking water, the feeding environment is 12 hours light and 12 hours dark cycle light, the temperature is controlled at 20±2°C, and the humidity is controlled at 50±5%.

[0063] 2. Feeding dosage and experimental steps:

[0064] Cataracts were induced in mice by ultraviolet UVB emitted from an ultraviolet lamp (French Vilber Lourmat Company, lamp tube model VL-6MCUVB). The experiment was carried out for 29 days in total. Before the experiment, the mice were randomly divided into 6 groups, with 3 mice in each group:

[0065] (1) Water-soluble control group: daily tube feeding of...

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Abstract

The invention discloses Cordyceps sobolifera mycelium for preventing, delaying or treating cataract, an active substance thereof, a mycelium liquid fermentation product thereof, a pharmaceutical composition thereof, and a method for preparing the product. The Cordyceps sobolifera mycelium, the active substance and the mycelium liquid fermentation product can be prepared as a health food for preventing or delaying cataract.

Description

technical field [0001] The present invention relates to an active substance. In particular, the present invention relates to a liquid fermented mycelia active substance of Cordyceps cicadae and its pharmaceutical composition, which are used for preventing, delaying or treating cataract. Background technique [0002] The crystals in the human eye are composed of water and protein fibers. The protein fibers are arranged in a specific way that makes the crystal clear and allows light to pass through. With the increase of age or exposure to risk factors, protein fibers degenerate and gather together, making the lens harden and cloudy, forming cataracts. At this time, it is impossible or difficult for light to pass through the lens from the cornea to focus and project on the retina, making the human body feel blurred vision and even unable to see objects. [0003] Therefore, cataract refers to the soluble protein in the lens gradually becomes insoluble protein and forms turbid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/068A61P27/12
CPCA61K36/068A23L33/10A23V2002/00A61K2236/19A23V2200/30A23V2250/208
Inventor 林培正张菡馨陈劲初陈炎鍊叶淑幸李丽雅徐瑞霞盛丽莎
Owner GRAPE KING
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