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A traditional Chinese medicine composition for preventing and treating proteinuria and its application

A composition and proteinuria technology, which is applied in the direction of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, can solve problems such as difficult quality control, complex polysaccharide and polypeptide extraction processes, and high cost

Active Publication Date: 2021-07-06
上海复活石医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the cocoon shell polypeptide and corn silk polysaccharide in this patent are only part of the active ingredients of silkworm cocoon shell and corn silk, but the extraction process of polysaccharide and polypeptide is complicated, and the quality control is difficult, which leads to relatively high cost

Method used

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  • A traditional Chinese medicine composition for preventing and treating proteinuria and its application
  • A traditional Chinese medicine composition for preventing and treating proteinuria and its application
  • A traditional Chinese medicine composition for preventing and treating proteinuria and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: oral liquid

[0018] The raw materials are taken according to the following weight ratio: 300 grams of cocoon shells, 300 grams of corn silk, 100 grams of astragalus, 60 grams of salvia miltiorrhiza, and 60 grams of chuanxiong. Add water to decoct the above 5 flavors twice, count from boiling, each time for 1 hour, add 10 times the amount of water for the first time, add 8 times the amount of water for the second time, after the decoction is completed, combine the two decoction liquids, and let cool 3000rpm Centrifuge for 10 minutes, remove the supernatant, concentrate, then add suitable auxiliary materials, make 1L of oral liquid according to the existing known method, and divide it into 10ml per bottle to get it. Oral 3 times a day, 1 bottle each time.

Embodiment 2

[0019] Embodiment 2: Granules

[0020] The raw materials are taken according to the following weight ratio: 300 grams of cocoon shells, 300 grams of corn silk, 100 grams of astragalus, 60 grams of salvia miltiorrhiza, and 60 grams of chuanxiong. Add water to decoct the above 5 flavors twice, count from boiling, each time for 1 hour, add 10 times the amount of water for the first time, add 8 times the amount of water for the second time, after the decoction is completed, combine the two decoction liquids, and let cool 3000rpm Centrifuge for 10 minutes, remove the supernatant, concentrate to an extract with a specific gravity of 1.35, add appropriate amount of dextrin and powdered sugar, dry at 70°C, make granules of 1000 g, granulate, and pack in 5 g per bag to obtain , orally 3 times a day, 1 bag each time.

[0021] The extraction method of sugar-free granules is the same as that of sugar-containing granules. When the extract is prepared into a 1.35 extract, add appropriate amo...

Embodiment 3

[0022] Embodiment 3: tablet

[0023] The raw materials are taken according to the following weight ratio: 300 grams of cocoon shells, 300 grams of corn silk, 100 grams of astragalus, 60 grams of salvia miltiorrhiza, and 60 grams of chuanxiong. Add water to decoct the above 5 flavors twice, count from boiling, each time for 1 hour, add 10 times the amount of water for the first time, add 8 times the amount of water for the second time, after the decoction is completed, combine the two decoction liquids, and let cool 3000rpm Centrifuge for 10 minutes, take the supernatant, reduce and concentrate to dry paste, and then make tablets according to the known method in the prior art, each tablet is 0.3 g, orally 3 times a day, 3 tablets each time.

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Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating proteinuria, which is composed of the following raw materials in parts by weight: 1-20 parts of silkworm cocoon shells, 1-20 parts of corn silk, 0-20 parts of astragalus, 0-20 parts of salvia miltiorrhiza, 0-20 parts of Chuanxiong ~20 servings. In addition, the invention also discloses the application of the traditional Chinese medicine composition in the preparation of medicines and health care products for preventing and treating proteinuria. Animal experiments and clinical experiments have shown that the present invention has good safety and good curative effect, and can reduce diabetic nephropathy, membranous nephropathy, primary nephritis, IgA nephropathy, purpura nephritis, lupus nephritis, hypertensive nephropathy, gouty nephropathy, etc. Proteinuria caused by different etiologies such as kidney disease, chronic renal failure, chronic nephritis, nephrotic syndrome, lupus nephritis, and urinary tract infection. The traditional Chinese medicine composition is effective in improving clinical symptoms, has little toxic and side effects, has good clinical application prospects, and has a simple extraction process, is easy to prepare, and reduces the preparation cost.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for preventing and treating proteinuria and its application. Background technique [0002] Globally, Chronic Kidney Disease (CKD) has been recognized as a major public health problem. According to statistics, in Asia, Europe, Australia and the United States, 10% to 16% of people suffer from chronic kidney disease to varying degrees. Since it takes several years for most patients with chronic kidney disease to gradually transform into the end-stage of chronic renal insufficiency, it is necessary to delay or even reverse the pathological changes of the kidneys in patients with chronic kidney disease. When the kidney is diseased, the permeability of the glomerular filtration membrane is increased, and proteinuria will appear; when the renal tubular reabsorption is dysfunctional, the protein reabsorption in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61P13/12A61P13/02A61P31/00A61K35/64
CPCA61K36/899A61P13/02A61P13/12A61P31/00A61K35/63A61K35/64A61K36/236A61K36/481A61K36/537A61K2300/00
Inventor 杨茗橘程芬
Owner 上海复活石医药科技有限公司
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