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Nano-crystalline cellulose/gelatin composite aerogel and application thereof

A nanocellulose and composite aerogel technology, applied in aerogel preparation, colloid chemistry, colloid chemistry, etc., can solve the problems of loss of mechanical properties and high degradation rate, and achieve good biocompatibility and degradability. Effect

Active Publication Date: 2019-01-18
NANJING FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The water solubility, biodegradability, biocompatibility and chemical modification of gelatin make it a promising drug carrier, but the rapid loss of its mechanical properties due to the high degradation rate limits its development to a certain extent. its application

Method used

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  • Nano-crystalline cellulose/gelatin composite aerogel and application thereof
  • Nano-crystalline cellulose/gelatin composite aerogel and application thereof
  • Nano-crystalline cellulose/gelatin composite aerogel and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045] 1. Preparation of nanocellulose dispersion by TEMPO-mediated oxidation

[0046] First, 10 g of dry fiber slurry was soaked in 500 mL of deionized water, followed by adding TEMPO (0.16 g) and NaBr (1.6 g) and stirring continuously at room temperature to make it evenly mixed. Then add 120mL NaClO (7.6mmol / L) solution to start the oxidation reaction. During the reaction, the pH value of the entire reaction system was maintained between 10-10.5 until the pH value no longer decreased, and 50 mL of ethanol was added to terminate the reaction. Soak the reacted slurry in 0.1mol / L HCl for acidification and washing. Then the washed slurry was quantified to 1%, the pH value of the quantified solution was adjusted to 10 again, and finally ultrasonic treatment was performed for 20 minutes under ultrasonic waves to obtain a uniform and transparent nanocellulose dispersion.

[0047] 2. Preparation of nanocellulose / gelatin composite airgel, the steps are as follows:

[0048] 1) The ...

Embodiment 2

[0072] Example 2 Preparation of nanocellulose / gelatin composite airgel loaded with 5-fluorouracil

[0073] A cylindrical HDPE cup (diameter 40 mm, height 50 mm) was used as a mold for preparing the composite airgel. The nanocellulose and gelatin solution were blended at a mass ratio of 3:7, and stirred rapidly with a magnetic stirrer at 60 °C for 2 h to disperse evenly. Add 2.5wt% (relative to the total mass of airgel) of 5-fluorouracil, and then add 10wt% gelatinized dialdehyde starch (relative to the total mass of nanocellulose and gelatin) to the homogeneously mixed nanocellulose and gelatin The mixed solution was reacted at 90°C for 4 h to obtain a uniform and transparent solution. The cross-linked sample solution was pre-cooled at 4°C for 12 hours to form a hydrogel, then quickly frozen with liquid nitrogen, and freeze-dried in a freeze dryer at -91°C for 3 days. Finally, the obtained airgel was cured in an oven at 110° C. for 2 hours to obtain a nanocellulose / gelatin a...

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Abstract

The invention discloses nano-crystalline cellulose / gelatin composite aerogel and an application thereof. The composite aerogel is prepared by steps as follows: 1), preparing a nano-crystalline cellulose dispersion liquid; 2), weighing gelatin particles, adding the gelatin particles to the nano-crystalline cellulose dispersion liquid for dissolving and blending, and performing stirring and uniformdispersing; 3), adding gelatinized dialdehyde starch to the nano-crystalline cellulose / gelatin mixed solution which is mixed uniformly, and performing temperature-control reaction to obtain a uniformand transparent solution; 4), precooling the solution obtained in step 3) to form hydrogel, quickly freezing the hydrogel by adopting liquid nitrogen, and performing freeze drying in a freeze dryer toobtain a nano-crystalline cellulose / gelatin aerogel sample; 5), curing the obtained aerogel in a drying oven to obtain the aerogel. The nano-crystalline cellulose / gelatin composite aerogel material is prepared by hydrogen-bond interaction and dialdehyde starch chemical crosslinking, has better biocompatibility and biodegradability, can be used as a drug sustained-release material and has good practicability.

Description

technical field [0001] The invention belongs to the technical field of gel and drug sustained release thereof, and in particular relates to a nanocellulose / gelatin composite airgel and an application thereof. Background technique [0002] In the past decades, drug delivery systems, especially those with targeted and sustained release, have received increasing attention due to potential advantages such as effective therapeutic effects and less side effects. The traditional route of intravenous administration can make the human body obtain complete drug utilization immediately and accurately administer the drug, but because the high-concentration drug will also be transported to normal tissues at the same time, this high-concentration drug has potential damage to normal tissues. Safety hazards (Deshpande A A, Rhodes C T, Shah N H, et al. Drug Development and Industrial Pharmacy, 1996, 22(6):531-539). Oral drug delivery has long been considered an ideal sustained-release drug ...

Claims

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Application Information

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IPC IPC(8): B01J13/00A61K9/19A61K31/513A61K47/38A61K47/42A61P35/00
CPCA61K9/19A61K31/513A61K47/38A61K47/42A61P35/00B01J13/0091
Inventor 吴伟兵宋如愿李建戴红旗
Owner NANJING FORESTRY UNIV
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