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Method for forming porous bone hydroxyapatite ceramic cytoskeleton based on photo-curing 3D printing technology

A bone hydroxyapatite and 3D printing technology, which is applied to ceramic molding machines, supply devices, manufacturing tools, etc., can solve the problems of inability to produce cell scaffold structures and complex structure hydroxyapatite samples, and achieve High molding precision, good biocompatibility, and the effect of promoting proliferation and differentiation

Pending Publication Date: 2019-01-18
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The traditional methods of making hydroxyapatite samples include dry press molding, injection molding, and grouting molding, etc., which cannot make hydroxyapatite samples with complex structures, nor can they produce voids with precise pore diameters. Cell Scaffold

Method used

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  • Method for forming porous bone hydroxyapatite ceramic cytoskeleton based on photo-curing 3D printing technology
  • Method for forming porous bone hydroxyapatite ceramic cytoskeleton based on photo-curing 3D printing technology
  • Method for forming porous bone hydroxyapatite ceramic cytoskeleton based on photo-curing 3D printing technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Embodiment 1, porous bovine bone hydroxyapatite cell scaffold

[0072] 1. The bovine cortical bone is pulverized with a pulverizer, dehydrated and degreased with ethanol, cleaned with ethanol ultrasonic wave, and dried. After calcining at 700°C for 2 hours, it was ground through a 100-mesh sieve.

[0073] 2. Put bovine cortical bone powder into a planetary ball mill, use zirconia balls with a diameter of 3 to 5 mm, the ball to material ratio is 1:4, the ball milling speed is 250 to 300 r / min, and the ball mill is 12 to 14 hours to obtain an average particle size of less than 20 μm bovine bone hydroxyapatite powder.

[0074] 3. The ball-milled bovine bone hydroxyapatite powder and carbon powder are dispersed by ball milling in a mass ratio of 4:1.

[0075] 4. Add the bone hydroxyapatite composite powder and other additives into the photocurable resin three times, and stir at normal pressure for 5-10 minutes after each addition until the weight of the bovine bone hydrox...

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Abstract

The invention discloses a method for forming a porous bone hydroxyapatite ceramic cytoskeleton based on a photo-curing 3D printing technology. The method mainly includes the five steps of ball-millingbone hydroxyapatite powder, mixing a pore forming agent, preparing photo-curing resin slurry, forming a ceramic blank through photo-curing, and degreasing and sintering the blank. The technological steps are simple, a complicated skeleton structure which cannot be formed through a traditional method can be formed, and the cytoskeleton similar to a human skeleton in structure and component can beprepared through a hollowed-out topological structure, especially a porous structure with two types of apertures.

Description

technical field [0001] The invention relates to a method for forming a porous bone hydroxyapatite ceramic cell scaffold based on photocuring 3D printing technology Background technique [0002] Hydroxyapatite is the most widely used bioactive ceramic (hydroxyapatite, referred to as HA or HAP), which is the main inorganic component of human and animal bones. one of the subjects. Hydroxyapatite has good biocompatibility. It is not only safe and non-toxic to implant in the body, but also has certain bone conduction. Hydroxyapatite material has a wide range of applications and broad development prospects in artificial hip joints, artificial prostheses, dentures, surgical scaffolds, and cell scaffolds. [0003] Hydroxyapatite is the main inorganic component of vertebrate bones and teeth. The content of hydroxyapatite in human tooth enamel is about 96Wt.% (92Vol.%), and it also accounts for about 69Wt.% in bones. Hydroxyapatite has excellent biocompatibility and bioactivity, an...

Claims

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Application Information

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IPC IPC(8): B28B1/00B28B13/02B33Y10/00B33Y40/00C04B35/447C04B35/634C04B38/02C04B38/06
CPCC04B35/447C04B35/634C04B38/02C04B38/067B28B1/001B28B13/0235B33Y10/00B33Y40/00C04B2235/6026
Inventor 沈理达刘子博焦晨田宗军顾凯杰曹颖顾嘉俊
Owner NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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