Self-microemulsion of fructus forsythiae volatile oil and its preparation method

A technology of volatile oil and self-microemulsion, which is applied in the direction of pharmaceutical formula, emulsion delivery, medical preparations of non-active ingredients, etc., can solve the problems of low feasibility, unstable properties, poor water solubility, etc., and achieve improved drug release speed, Convenient clinical medication and high stability

Active Publication Date: 2019-01-25
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has poor water solubility, is volatile, and has unstable properties. At present, there are few research reports on related preparations, such as Li Fan. Research on pharmacodynamics and self-emulsifying drug delivery system of different fractions of Forsythia volatile oil [D]. Xi'an: Northwest University: 2009 33 (02): 1-72., use visual inspection and manual stirring to observe the area of ​​oil droplets on the emulsified liquid surface and whether it is layered to optimize the formula composition. There are human errors in the experimental data and lack of scientific basis. The optimized prescription and emulsification energy High, requires higher cost in actual production, complex operation, low feasibility

Method used

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  • Self-microemulsion of fructus forsythiae volatile oil and its preparation method
  • Self-microemulsion of fructus forsythiae volatile oil and its preparation method
  • Self-microemulsion of fructus forsythiae volatile oil and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Example 1. Preparation of Volatile Oil of Forsythia Suspense

[0022] Take 50g of Forsythia suspensa raw medicinal material in a flask, add 500ml of water and several glass beads, shake and mix, connect the volatile oil tester and reflux condenser. Add water from the upper end of the condenser tube to fill the scale part of the volatile oil tester and overflow into the flask. Slowly heat to boiling in an electric heating mantle, and keep it boiling for 5 hours until the oil in the tester no longer increases, stop heating, leave it for a while, turn on the piston at the lower end of the tester, and slowly release the water until the upper end of the oil layer reaches the mark Up to 5mm above the 0 line. Placed for more than 1 hour, recovered, and dehydrated by adding anhydrous sodium sulfate to obtain a light yellow clear oily liquid with an extraction rate of 1.7%, which is the volatile oil of Forsythia.

Embodiment 2

[0023] Example 2. Preparation of Forsythia Suspense Oil Self-Microemulsion

[0024] a. After mixing Tween-20 and ethanol at a volume ratio of 81:9, mix with ethyl oleate at a volume ratio of 90:10, and stir evenly to obtain Tween-20: ethanol: ethyl oleate (81: 9:10) mixture;

[0025] b. After the volatile oil of Forsythia is mixed with the mixed liquid at a volume ratio of 25:100, it is heated and dissolved in a water bath at 37°C, and stirred evenly to obtain a clear and transparent oil phase;

[0026] c. At the temperature of 37℃, the speed is 100r·min -1 Under magnetic stirring, the oil phase was dripped into 37℃ deionized water at a volume ratio of 1:100 to self-emulsify, and the light transmittance at 600nm wavelength was measured every 30s until the light transmittance was stable and the emulsification was complete. Let it stand for 24 hours to obtain the forsythia volatile oil self-microemulsion.

[0027] The following examples illustrate the beneficial effects of the present ...

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Abstract

The invention relates to a self-microemulsion of forsythia volatile oil, which is characterized in that the self-microemulsion is prepared from the following raw materials in parts by weight: 10 partsof ethyl oleate, 81 parts of tween-20, 9 parts of ethanol and 11-25 part of forsythia volatile oil. The invention also provides a preparation method of the self-microemulsion of the volatile oil of Forsythia suspensa, wherein the self-microemulsion of the volatile oil of Forsythia suspensa produced by the invention has the advantages of clear and transparent appearance, uniform light blue emulsion, particle size less than 100nm, and good stability.

Description

Technical field [0001] The invention relates to a self-microemulsion of forsythia volatile oil and a preparation method thereof. Background technique [0002] Self-microemulsifying drug delivery system (SMEDDS) is a solid or liquid system containing oil phase, emulsifier, and co-solvent. The free energy required for emulsification is very low. It can be used in a 37°C water bath in vitro, under gentle stirring, or gastrointestinal peristalsis in vivo It spontaneously spontaneously becomes a microemulsion, forming a self-emulsifying drug delivery system with a particle size below 100nm. SMEDDS has good physical stability and small size, which is a better oral administration form than emulsion. As an excellent drug delivery system, SMEDDS can effectively increase the solubility of poorly soluble drugs, and due to the large dispersion of the emulsion droplets and rapid drug absorption, it can significantly improve the bioavailability. [0003] Forsythia is the dried fruit of Forsy s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K36/634A61K47/26A61P29/00A61P31/04A61P31/10A61P31/12
CPCA61K9/0053A61K9/1075A61K36/634A61K47/26A61P29/00A61P31/04A61P31/10A61P31/12
Inventor 李芸霞曹小玉彭成郑立汤韵秋余琳媛周忆梦全云云刘美辰
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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