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Upper gastrointestinal flora-improving agent

A digestive tract and improver technology, applied in the direction of the digestive system, lactobacillus, bacteria used in food preparation, etc., can solve the problems associated with side effects, etc.

Active Publication Date: 2019-02-05
MEIJI CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned administration is accompanied by side effects, so it is desired to prevent or improve functional gastrointestinal disorders by a method without side effects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Contains Lactobacillus gasseri ( Lactobacillus gasseri ) OLL 2716 (FERM BP-6999) is a solid upper gastrointestinal microflora improving agent as an active ingredient, prepared by the following method. Raw material milk, skimmed milk powder, and water were appropriately prepared so that the milk fat content was 3.0% by weight and the non-fat milk solid content was 9.2% by weight, and the resulting mixture was homogenized by conventional methods, sterilized, and cooled. After that, Lactobacillus bulgaricus, Streptococcus thermophilus and Lactobacillus gasseri ( Lactobacillus gasseri ) OLL 2716 (FERM BP-6999), cultivated according to conventional methods, with the resulting culture as Example 1 (upper gastrointestinal flora improving agent). It should be noted that, for the sake of convenience, the agent for improving flora in the upper digestive tract is in the form of directly ingesting lactic acid bacteria containing active ingredients.

[0069] In this upper gastro...

test approach 1

[0071] An intervention test was carried out using the agent for improving flora in the upper gastrointestinal tract of Example 1 (hereinafter, this may be referred to as a test sample.).

[0072] Specifically, 24 pylori-negative patients with functional gastrointestinal disorders without organic disease were selected as subjects. In addition, as a control, 21 healthy persons without organic diseases and negative for pylori were used as subjects.

[0073] Then, the above-mentioned 24 patients with functional gastrointestinal disorders were asked to ingest the upper gastrointestinal flora improving agent at 118 g per day for 12 consecutive weeks.

[0074] Moreover, the gastric juices of the above-mentioned 24 patients with functional gastrointestinal disorders were passed through a nasogastric tube (naso-gastric tube) before taking the upper gastrointestinal microflora improving agent and after taking it continuously for 12 weeks. state, obtained directly from the stomach. Sim...

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PUM

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Abstract

The problem is solved by an upper gastrointestinal flora-improving agent, the agent containing lactobacilli as an active ingredient, to be used in persons positive and negative for Helicobacter pylori. Lactobacilli of the genus Lactobacillus are preferably used as the lactobacilli, more preferably Lactobacillus gasseri OLL 2716 (FERM BP-6999). Improvement of the upper gastrointestinal flora is, for example, a reduction in upper gastrointestinal bifidobacteria and / or an increase in upper gastrointestinal Prevotella bacteria.

Description

technical field [0001] The present invention relates to an agent for improving the flora in the upper gastrointestinal tract and the like for improving the flora in the upper gastrointestinal tract. Specifically, it relates to an upper gastrointestinal bifidobacterium reducing agent for reducing upper gastrointestinal bifidobacteria and / or an upper gastrointestinal endobacteria increasing agent for increasing upper gastrointestinal endobacteria. Background technique [0002] In the past, although endoscopic diagnosis has progressed, epigastric pain or discomfort, stomach fullness after meals, epigastric fullness, nausea / vomiting, epigastric pain (upper abdominal pain), burning heart Complaints of digestive system symptoms such as flu, and unexplained symptoms are still common. Although there are such complaints of digestive system symptoms, no organic diseases can be found through ordinary examinations including endoscopy, and no clear symptoms can be obtained. This state i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/744A23L33/135A61K35/747A61P1/00A61P43/00
CPCA23L33/135A61P1/00A61P43/00A23V2002/00A23C9/123A61K2035/115A61K35/747A61P1/14A23V2200/3202A23V2400/145
Inventor 古贺泰裕中江浩彦大津俊广
Owner MEIJI CO LTD
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