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Preparation method of compound monoammonium glycyrrhizinate s sodium chloride injection

A technology of sodium chloride injection and monoammonium glycyrrhizinate, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, digestive system, etc. problems such as the dissolution of excipients, to achieve the effect of reducing the time required for preparation, improving the dissolution efficiency, and improving the preparation efficiency

Inactive Publication Date: 2021-04-20
湖北康沁药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the stability can be improved by preparing it into lyophilized powder, because the lyophilized powder needs to be further dissolved in clinical use, the chance of contamination is increased, so it is now mostly formulated into injection
In the preparation process of the traditional compound monoammonium glycyrrhizinate S sodium chloride injection, after adding the main drug monoammonium glycyrrhizinate, it becomes jelly-like, which is difficult to stir and dissolves slowly. It also affects the dissolution of other raw and auxiliary materials, which greatly increases the injection time. The difficulty and preparation time of liquid preparation affect production efficiency

Method used

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  • Preparation method of compound monoammonium glycyrrhizinate s sodium chloride injection
  • Preparation method of compound monoammonium glycyrrhizinate s sodium chloride injection
  • Preparation method of compound monoammonium glycyrrhizinate s sodium chloride injection

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The raw and auxiliary materials of the compound monoammonium glycyrrhizinate S sodium chloride injection include by parts by weight:

[0031]

[0032] Wherein, the compound monoammonium glycyrrhizinate S sodium chloride injection was made into 4000L in total;

[0033] The preparation steps are:

[0034] S1. Mix 2.0Kg of activated carbon with water for injection and activated carbon according to the ratio of 1L: 0.4Kg to make paste-like activated carbon;

[0035] S2. Add 36Kg of sodium chloride to 350L of water for injection, stir to dissolve, then add paste-like activated carbon containing 1Kg of activated carbon, heat and boil for 40 minutes, cool down, filter and remove carbon, and send it to the dilute distribution tank;

[0036] S3, add 600L of water for injection into the concentrated preparation tank, add 3.2Kg of anhydrous sodium sulfite, and stir to dissolve;

[0037] S4. Stir and dissolve 500g of sodium hydroxide with water for injection and sodium hydroxi...

Embodiment 2

[0044] The raw and auxiliary materials of the compound monoammonium glycyrrhizinate S sodium chloride injection include by parts by weight:

[0045]

[0046] Wherein, the compound monoammonium glycyrrhizinate S sodium chloride injection was made into 4000L in total;

[0047] The preparation steps are:

[0048] S1. Mix 2.0Kg of activated carbon with water for injection and activated carbon according to the ratio of 1L: 0.8Kg to make paste-like activated carbon;

[0049] S2. Add 36Kg of sodium chloride to 240L of water for injection, stir to dissolve, then add paste-like activated carbon containing 1.4Kg of activated carbon, heat and boil for 20 minutes, cool down, filter and remove carbon, and then send it to the dilute distribution tank;

[0050] S3, add 1000L of water for injection into the concentrated preparation tank, add 3.2Kg of anhydrous sodium sulfite, and stir to dissolve;

[0051] S4. Stir and dissolve 500g of sodium hydroxide with water for injection and sodium...

Embodiment 3

[0058] The raw and auxiliary materials of the compound monoammonium glycyrrhizinate S sodium chloride injection include by parts by weight:

[0059]

[0060]

[0061] Wherein, the compound monoammonium glycyrrhizinate S sodium chloride injection was made into 4000L in total;

[0062] The preparation steps are:

[0063] S1. Mix 2.0Kg of activated carbon with water for injection and activated carbon according to the ratio of 1L: 0.6Kg to make paste-like activated carbon;

[0064] S2. Add 36Kg of sodium chloride to 300L of water for injection, stir to dissolve, then add paste-like activated carbon containing 1.2Kg of activated carbon, heat and boil for 30 minutes, cool down, filter and remove carbon, and then send it to the dilution tank;

[0065] S3, add 800L of water for injection into the concentrated preparation tank, add 3.2Kg of anhydrous sodium sulfite, and stir to dissolve;

[0066]S4. Stir and dissolve 500g of sodium hydroxide with water for injection and sodium ...

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Abstract

A preparation method of compound monoammonium glycyrrhizinate S sodium chloride injection belongs to the field of preparation methods of injections, and comprises: monoammonium glycyrrhizinate, cysteine ​​hydrochloride, glycine, sodium chloride, anhydrous sodium sulfite, and Disodium dibasic acid, sodium hydroxide, gac, water for injection; In the present invention, sodium hydroxide is first dissolved in water for injection and is mixed with sodium hydroxide solution and then adds monoammonium glycyrrhizinate and stirs and dissolves, which can greatly reduce the concentration of glycyrrhizinate monoammonium. The dissolving time of ammonium improves the dissolving efficiency of monoammonium glycyrrhizinate; at the same time, in the present invention, some steps can be carried out at the same time, which greatly reduces the time required for preparation and improves the overall preparation efficiency, and the effect is obvious.

Description

technical field [0001] The invention relates to the field of preparation methods of injections, in particular to a preparation method of compound monoammonium glycyrrhizinate S sodium chloride injection. Background technique [0002] Compound monoammonium glycyrrhizinate is used for abnormal liver function caused by acute, chronic and persistent hepatitis; it has certain adjuvant therapeutic effect on toxic hepatitis, traumatic hepatitis and cancer. It can also be used for food poisoning, drug poisoning, drug allergy, etc. [0003] At present, the compound monoammonium glycyrrhizinate preparations for clinical application include injection, freeze-dried powder and the like. Although the stability can be improved by preparing it into lyophilized powder, because the lyophilized powder needs to be further dissolved during clinical use, the chance of contamination is increased, so it is now mostly formulated into injections. In the preparation process of the traditional compou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/198A61K31/704A61K47/02A61K9/08A61P1/16A61P35/00
CPCA61K9/0019A61K9/08A61K31/198A61K31/704A61K47/02A61P1/16A61P35/00A61K2300/00
Inventor 冯雨
Owner 湖北康沁药业股份有限公司