N-difluoromethylazole sulfur (selenium) urea derivative and preparation method thereof

A technology of difluoromethyl imidazole thiourea and difluoromethyl triazole thiourea, which is applied in the field of N-difluoromethyl azole thiourea derivatives and its preparation, and can solve the problem of functional group damage, difficulty in obtaining, unfavorable Problems such as the construction of drug molecular libraries, to achieve the effect of mild conditions
CN109369538AActive Publication Date: 2019-02-22SOUTH CHINA AGRI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SOUTH CHINA AGRI UNIV
Publication Date
2019-02-22

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Abstract

The invention discloses an N-difluoromethylazole sulfur (selenium) urea derivative and a preparation method thereof. The N-difluoromethylazole sulfur (selenium) urea derivative comprises N-difluoromethyl benzimidazole sulfourea, N-difluoromethyl imidazole sulfourea, N-difluoromethyl triazole sulfourea and an relevant N-difluoromethyl selenourea derivative; and a benzimidazole derivative, an imidazole derivative or a triazole derivative, elemental sulfur powder or selenium powder, and a catalyst are added into a reaction tube, an organic solvent is added into the reaction tube, halohydrocarbonis injected into the reaction tube, and reacting is carried out under a heating condition to obtain the N-difluoromethylazole sulfur (selenium) urea derivative. The preparation method is simple and easy to operate, the condition is mild, the cheap and economical effects are achieved, and the provided compounds have important potential application value in pesticides, medicines and organic functional materials.
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Description

technical field

[0001] The invention belongs to the technical field of organic chemical reactions, and in particular relates to an N-difluoromethylazole thio(selenium) urea derivative and a preparation method thereof. Background technique

[0002] Azole compounds such as benzimidazole, imidazole, triazole and other derivatives have important applications in the field of medicine and materials, and play an important role in the creation of new and efficient drugs. Due to their high efficiency, low toxicity, excellent biological activity and various structural changes, these compounds have been widely used in pesticides and medicines, and have always been the focus and focus of organic chemistry research. (Li Yan, Organic Chemistry, 2007, 28(2): 210-217; Zhang Ying, Pesticides, 2008, 47(3), 164-170). Selective fluorination and fluoroalkylation of organic compounds lead to dramatic changes in the electronic effects and skeletal characteristics of the products. Such fluorine-c...

Claims

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