Dual-emission fluorescent molecularly imprinted polymer nanoparticles and preparation method and application thereof

A dual emission fluorescence, molecular imprinting technology, applied in nanotechnology, nanotechnology, luminescent materials, etc., can solve the problems of dopamine human harm, complicated processing, expensive chromatography equipment, etc. fast effect
CN109370565AActive Publication Date: 2019-02-22JIANGSU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JIANGSU UNIV
Publication Date
2019-02-22

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Abstract

The invention relates to the technical field of preparation of bio-functional materials, in particular to dual-emission fluorescent molecularly imprinted polymer nanoparticles and a preparation methodand application thereof. carbon quantum dots are coated with silica nanospheres to form a core of a ratio fluorescence probe; red cadmium telluride quantum dots are used as response signals, acrylamide and 4-vinylbenzeneboronic acid are used as bifunctional monomers, N,N-methylene bisacrylamide is used as a crosslinker, dopamine is used as templating molecules, dual-emission fluorescent molecularly imprinted polymer nanoparticles having specific recognition sites for dopamine are synthesized in an alcohol phase under initiating of azodiisobutyronitrile, and fluorescent detection test paper with visualizing effect is prepared then by means of impregnating so as to provide visual detection for DA (dopamine); the fluorescent detection test paper is applied to the detection of DA in a human serum sample, and the results prove that the fluorescent detection test paper prepared herein is suitable for half-quantitative detection of DA in actual complex samples.
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Description

Technical field

[0001] The invention relates to the technical field of biological functional material preparation, in particular to a dual-emission fluorescent molecularly imprinted polymer nanoparticle, and a preparation method and application thereof. Background technique

[0002] Molecular imprinting technology (Molecular imprinting technology, MIT) is a process of preparing polymers with specific recognition ability for a specific molecule, and can be used to prepare molecularly imprinted polymers (MIPs) with specific selectivity. Fluorescence analysis has the advantages of fast, simple, sensitive, etc., and has great potential in the field of analysis. Compared with high-performance liquid chromatography and other advanced instrument analysis, it is relatively large in terms of solvent consumption, sample pre-processing, and test time. The advantages.

[0003] More and more scientific researchers choose quantum dots as the emission source of fluorescent signals, and use the s...

Claims

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