Method for preparing methylene blue-containing silicon dioxide/carbon compound particles with high fluorescence intensity by means of hydrothermal method

Abstract

The invention provides a method for preparing methylene blue-containing silicon dioxide / carbon compound particles with high fluorescence intensity by means of a hydrothermal method, and belongs to thetechnical field of chemical raw material production. Firstly, after ammonium hydroxide, methylene blue and tetraethoxysilane are added into a mixed solution which contains water and ethyl alcohol, stirring is conducted for 4 hours, centrifugation and washing are conducted, drying is conducted at 70 DEG C, then prepared methylene blue-containing silicon dioxide particles are dispersed in a glucose-containing aqueous solution, reaction is carried out at 120-180 DEG C for 4 hours, centrifugal separation is conducted, and an obtained precipitate is dried at 80 DEG C after being washed, so that the methylene blue-containing silicon dioxide / carbon compound particles with the high fluorescence intensity are obtained. According to the method, the process is simple, the raw materials are cheap, industrial production is easy, and the obtained particles are good in biocompatibility, high in fluorescence intensity and good in fluorescence stability.

Description

technical field [0001] The invention discloses a method for preparing methylene blue-containing silicon dioxide / carbon composite particles with high fluorescence intensity by using a hydrothermal method, which belongs to the technical field of chemical raw material preparation. Background technique [0002] As one of the important nanomaterials, silica nanoparticles are non-toxic, chemically inert and have good biocompatibility. After proper modification, silica nanoparticles can effectively transfect cells, deliver and control drug molecules in vitro. released, can also label and track biological tissues and organs. Because high fluorescence intensity is crucial for precise tracking of biological targets and in-depth study of biological dynamics, researchers hope that silica-based nanoparticles will have a bright fluorescence (photoluminescence) effect. [0003] However, since silicon dioxide has a wide bandgap (approximately 9eV), it cannot directly make silicon dioxide f...

AI Technical Summary

Problems solved by technology

Despite the success in preparing carbon nanodots with high fluorescence intensity, it is still challenging to preserve the luminescent properties of carbon nanodots in solid materials, because it was found in past studies that carbon nanodots in the dry and aggregated state The dots will undergo a strong fluorescence quenching reaction, resulting in unsatisfactory solid-state luminescence properties of carbon nanodots. In order to meet the application requirements of carbon-based nanomaterials in different fields, researchers need to further study carbon-based materials with different structures. research

So far, the method of complexing amorphous carbon on the surface of methylene blue-containing silica particles by hydrothermal method and preparing methylene blue-containing silica / carbon composite particles with high fluorescence intensity has not been reported.

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