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Charged biomimetic implantation film material regulated and controlled through magneto-electric coupling and preparation method thereof

A technology of magnetoelectric coupling and membrane materials, which can be applied in tissue regeneration, medical formula, medical science, etc., can solve the problems of unstable long-term repair effect and potential attenuation, and achieve good bone defect repair effect, good flexibility and product effect stable effect

Pending Publication Date: 2019-03-01
PEKING UNIV SCHOOL OF STOMATOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the technical problems of potential attenuation after long-term implantation of existing charged biomaterials and unstable long-term repair effect, and provides a charged bionic implantation film with simple preparation method, stable product effect and high yield Materials and Preparation Methods

Method used

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  • Charged biomimetic implantation film material regulated and controlled through magneto-electric coupling and preparation method thereof
  • Charged biomimetic implantation film material regulated and controlled through magneto-electric coupling and preparation method thereof
  • Charged biomimetic implantation film material regulated and controlled through magneto-electric coupling and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0026] (1) Weigh 0.11g of cobalt ferrite nanoparticles, add them to 20ml of azatrimethylformamide, and vibrate ultrasonically for 3 hours to obtain a uniformly dispersed magnetic nanoparticle dispersion;

[0027] (2) Weigh 2g of polymer P (VDF-TrFE) and add it to the magnetic nanoparticle dispersion obtained in step (1) to make the concentration of the polymer solution 0.1g / ml, and make the cobalt ferrite magnetic particles in the polymer The mass percentage in the matrix is ​​5%, ultrasonic and stirring for 3 hours, so that the magnetic particles are uniformly dispersed in the polymer matrix, and a mixture of magnetic particles and ferroelectric polymer matrix is ​​obtained;

[0028] (3) Cast the mixed solution obtained in step (2) in a casting machine, and dry the film obtained by casting at a temperature of 40° C. to obtain a composite film material with a film thickness of 70 μm;

[0029] (4) The composite membrane material obtained in step (3) is annealed, the annealing temperat...

Embodiment 2

[0032] (1) Weigh 0.22 g of cobalt ferrite nanoparticles, add them to 20 ml of organic solvent nitrosidine dimethylformamide, and vibrate ultrasonically for 3 hours to obtain a uniformly dispersed magnetic nanoparticle dispersion;

[0033] (2) Weigh 2g of polymer P (VDF-TrFE) and add it to the magnetic nanoparticle dispersion obtained in step (1) to make the concentration of the polymer solution 0.1g / ml, and make the cobalt ferrite magnetic particles in the polymer The mass percentage in the matrix is ​​25%, ultrasonic and stirring for 3 hours, so that the magnetic particles are uniformly dispersed in the polymer matrix, and a mixture of magnetic particles and ferroelectric polymer matrix is ​​obtained;

[0034] (3) Cast the mixed solution obtained in step (2) in a casting machine, and dry the film obtained by casting at a temperature of 100°C to obtain a composite film material with a film thickness of 70 μm;

[0035] (4) The film material obtained in step (3) is annealed, and the an...

Embodiment 3

[0038] (1) Weigh 0.17 g of cobalt ferrite nanoparticles, add them to 20 ml of organic solvent nitrosidine dimethyl formamide, and vibrate ultrasonically for 3 hours to obtain a uniformly dispersed magnetic nanoparticle dispersion;

[0039] (2) Weigh 2g of polymer P (VDF-TrFE) and add it to the magnetic nanoparticle dispersion obtained in step (1) to make the concentration of the polymer solution 0.1g / ml, and make the cobalt ferrite magnetic particles in the polymer The mass percentage in the matrix is ​​15%, ultrasonic and stirring for 3 hours, so that the magnetic particles are uniformly dispersed in the polymer matrix, and a mixture of magnetic particles and ferroelectric polymer matrix is ​​obtained;

[0040] (3) Cast the mixed solution obtained in step (2) in a casting machine, and dry the film obtained by casting at a temperature of 70°C to obtain a composite film material with a film thickness of 70 μm;

[0041] (4) The film material obtained in step (3) is annealed, and the an...

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Abstract

The invention relates to a charged biomimetic implantation film material regulated and controlled through magneto-electric coupling and a preparation method thereof, aiming at solving the technical problems that the potential is attenuated and the long-period repair effect is not stable after an existing charged biological material is implanted for a long period. The charged biomimetic implantation film material is a thin-film-shaped material prepared from a ferroelectric high-molecular polymer, magnetic particle filler and an organic solvent. The invention also provides the preparation methodof the charged biomimetic implantation film material. The charged biomimetic implantation film material can be widely applied to the technical field of tissue defect repairing materials for surgicaloperations.

Description

Technical field [0001] The invention relates to the technical field of tissue defect repair materials for surgical operations, in particular to a charged bionic implant film material regulated by magnetoelectric coupling and a preparation method thereof. Background technique [0002] Repairing tissue defects by implantation is currently a common clinical treatment method. Due to the limited sources of autologous and allograft transplantation, secondary trauma infection in the donor site, and immune rejection, artificial repair materials have received extensive attention in recent years. With recent research, people have realized that the growth, development, and damage repair of organisms are related to the bioelectrical microenvironment in which they are located, and that the nervous system, cardiovascular system, and skeletal muscle all have physiological potentials. A large number of studies have confirmed that, Restoring the potential of the damaged area is helpful for the r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/50A61L27/54
CPCA61L27/446A61L27/50A61L27/54A61L2300/412A61L2400/12A61L2430/02C08L27/16
Inventor 刘雯雯邓旭亮张冯依
Owner PEKING UNIV SCHOOL OF STOMATOLOGY
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