Application of abietane type diterpene compounds

Abstract

The invention discloses an application of abietane type diterpene compounds. The formula of the abietane type diterpene compounds is represented by the formula I. At least one of the compounds represented by the formula I, and hydrates, pharmaceutically acceptable salts, tautomer, stereoisomer, and precursor thereof is taken as an active component to prepare drugs or health care food for inhibiting mast cell de-granulation. The results of experiments show that the compounds represented by the formula I can prominently inhibit mast cell de-granulation, can be used as an active component to prepare drugs or health care food for inhibiting mast cell de-granulation, further can be used as an active component to prepare a mast cell stabilizer, and can be used to prepare drugs or health care food for preventing or / and treating allergic diseases caused by mast cell de-granulation.

Description

technical field

[0001] The invention relates to a new application of an abietane-type diterpene compound and belongs to the technical field of medicine. Background technique

[0002] Allergy, also known as an allergic disease, is an overreaction of the immune system caused by substances in the environment that are not harmful to humans (McConnell T H. The nature of disease: pathology for the health professions[M]. Lippincott Williams&Wilkins, 2007 ). Common allergic diseases mainly contain hay fever, food allergy, atopic dermatitis and allergic asthma etc. (Kay A B.Allergy and allergic diseases[J].New England Journal of Medicine,2001,344(1):30- 37), the main symptoms are skin redness, itching, runny nose and shortness of breath. With the development of modern industrialization, allergy has become the sixth largest disease in the world, which is posing a continuous health threat to people. According to media reports, about 22% of the world's population suffers from allergi...

Images