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A kind of compound electrolyte glucose injection and preparation method thereof

A technology of glucose injection and compound electrolyte, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve the problem of single ingredients and inability to fully meet the needs of human body water and electrolyte balance, etc. problem, to achieve the effect of reducing oxygen content, drug compliance and safety, and improving stability

Inactive Publication Date: 2021-07-20
JINAN KANGHE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Electrolyte injection mainly contains glucose and sodium chloride, which is relatively simple in composition and cannot fully meet the needs of the human body for water and electrolyte balance. Electrolyte ions, such as sodium ions, magnesium ions, calcium ions, organic acid ions, etc.

Method used

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  • A kind of compound electrolyte glucose injection and preparation method thereof
  • A kind of compound electrolyte glucose injection and preparation method thereof
  • A kind of compound electrolyte glucose injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044]

[0045] Preparation:

[0046] (1) Take by weighing 90% of the prescription amount of water for injection, keep it warm at 25°C, add the prescription amount of sodium bicarbonate, sodium chloride, potassium chloride, magnesium chloride, calcium chloride, sodium acetate, and L-malic acid into the water for injection in sequence, Stir to dissolve;

[0047] (2) add prescription amount of glucose and stir to dissolve; add acetic acid to adjust the pH of the above solution to 5.0;

[0048] (3) Constant volume, fine filtration through 0.22 μm filter membrane;

[0049] (4) Divide the obtained liquid medicine, fill with nitrogen, stopper, cover, and sterilize with damp heat at 126°C for 6 minutes to obtain the finished product.

Embodiment 2

[0051] Preparation:

[0052]

[0053] (1) Take by weighing 90% of the prescription amount of water for injection, keep it warm at 30°C, add the prescription amount of sodium bicarbonate, sodium chloride, potassium chloride, magnesium chloride, calcium chloride, sodium acetate, and L-malic acid into the water for injection in sequence, Stir to dissolve;

[0054] (2) Add the prescribed amount of glucose and stir to dissolve; add dilute hydrochloric acid to adjust the pH of the above solution to 6.0;

[0055] (3) Constant volume, fine filtration through 0.22 μm filter membrane;

[0056] (4) Divide the obtained liquid medicine, fill with nitrogen, stopper, cover, and sterilize with damp heat at 126°C for 10 minutes to obtain the finished product.

Embodiment 3

[0058]

[0059]

[0060] Preparation:

[0061] (1) Take by weighing 90% of the prescription amount of water for injection, keep it warm at 25°C, add the prescription amount of sodium bicarbonate, sodium chloride, potassium chloride, magnesium chloride, calcium chloride, sodium acetate, and L-malic acid into the water for injection in sequence, Stir to dissolve;

[0062] (2) add prescription amount of glucose and stir to dissolve; add acetic acid to adjust the pH of the above solution to 5.5;

[0063] (3) Constant volume, fine filtration through 0.22 μm filter membrane;

[0064] (4) Divide the obtained medicinal solution into packages, fill with nitrogen, stopper, cover, and sterilize with damp heat at 126°C for 8 minutes to obtain the finished product.

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PUM

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Abstract

The invention relates to a compound electrolyte glucose injection and a preparation method thereof. The 500ml injection includes: 0.8-3.0g sodium chloride, 0.4-1.2g potassium chloride, 0.1-0.4g magnesium chloride, 0.07-0.34g calcium chloride, 0.8-2.5g sodium acetate, 0.2-1.0g malic acid, Glucose 15-45g, sodium bicarbonate 0.5-2.0g, pH adjusted to 5.0-6.0. The preparation process of the injection comprises: dosing, filtering, filling, capping, sterilizing, and lamp inspection; the dosing adopts a one-step preparation method, and the preparation process adopts low-temperature preparation. This method is simple to operate and low in cost, and the prepared electrolyte glucose injection has good drug stability, less side effects, and high drug compliance and safety of patients, which meets the needs of patients for fluid replacement and electrolyte disturbance during surgery, and is suitable for liver Dysfunction, severe shock and pediatric patients.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a compound electrolyte glucose injection and a preparation method thereof. Background technique [0002] Compound Electrolyte Glucose Injection is suitable for patients who cannot eat, should not eat or eat seriously insufficient, and suffer from nutritional disorders and malnutrition after external gastrointestinal fistula, external pancreatic fistula or major pancreatectomy, total bowel or small bowel resection Preoperative preparation of patients; patients with poor general condition after receiving chemotherapy for malignant tumors; patients who cannot eat for a long time after major surgery are an important part of parenteral nutrition therapy. [0003] Glucose is a ubiquitous metabolic natural substrate in living cells. Glucose is the most important carbohydrate for energy supply under physiological conditions, and the energy supply of nerve tissue, e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K47/26A61K33/14A61P3/00A61P3/12A61K31/19A61K31/194A61K31/7004A61K33/00A61K33/06
CPCA61K9/0019A61K9/08A61K31/19A61K31/194A61K31/7004A61K33/00A61K33/06A61K33/14A61P3/00A61P3/12A61K2300/00
Inventor 王丽伟李鹏张颖张作平杨江勇李娟娟彭艳丽朱文霞
Owner JINAN KANGHE MEDICAL TECH
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