A kind of preparation method of dalbavancin

A technology of dalbavancin and synthetic route, which is applied in the field of antibiotic preparation, can solve the problems of high purification cost and difficulty in obtaining dalbavancin, and achieve the effects of reduced preparation cost, easy removal, and mild reaction conditions
CN109467592BActive Publication Date: 2020-07-03LIVZON NEW NORTH RIVER PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
LIVZON NEW NORTH RIVER PHARMA
Publication Date
2020-07-03

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Abstract

The invention discloses a method for preparing dalbavancin. The method comprises the following steps: protecting carboxyl of a complex A40926, carrying out an amidation reaction with 3,3-dimethylamino-1-propylamine, hydrolyzing in an alkaline solution, acidifying and purifying, so as to obtain the dalbavancin. According to the preparation method disclosed by the invention, the reaction conditionsare mild, the yield is high, the impurities are easily removed, and the preparation cost of the dalbavancin can be effectively reduced.
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Description

technical field

[0001] The invention relates to a preparation method of antibiotics, in particular to a preparation method of dalbavancin. Background technique

[0002] Dalbavancin (Dalbavancin), also known as Daucomycin, is a second-generation glycopeptide antibiotic with the following structural formula:

[0003]

[0004] Dalbavancin has the strongest activity among the second-generation glycopeptide antibiotics. Dalbavancin is one of the few drugs that can treat multidrug-resistant Staphylococcus aureus and Enterococcus infectious diseases, and has the properties of vancomycin and Teraconin has no anti-neisseria gonorrhoeae effect. It can be used to treat complicated skin and soft tissue infections and blood infections caused by urinary catheters, and is well tolerated. Indications for the treatment of skin and skin structure infection SSSI, approved for marketing in the United States (2014). Indications ABSSSI, acute bacterial skin and skin structure infection, was...

Claims

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