High-efficiency ionization probe electrospray mass spectrum ion source device and probe applicable to ion source device

Abstract

The invention relates to the technical field of detection and analysis, in particular to a high-efficiency ionization probe electrospray mass spectrum ion source device and a probe applicable to the ion source device. The high-efficiency ionization probe electrospray mass spectrum ion source device comprises a liquid phase capillary pipe, a probe fixed base, a nitrogen gathering system, a gas heating device, a three-dimensional fine adjustment control table and a probe. By the ion source device, the ionization efficiency and the ion transmission efficiency of a detection sample can be improved, so that the electrospray mass spectrum detection range of the probe is expanded. With the novel graphene oxide functional probe applicable to the high-efficiency ionization probe electrospray mass spectrum ion source device, provided by the invention, the enrichment capability and the enriching types of the probe can be improved, and the electrospray mass spectrum detection range of the probe isfurther expanded.

Description

Technical field [0001] The invention relates to the technical field of detection and analysis, in particular to a high-efficiency ionization probe electrospray mass spectrometry ion source device and a probe suitable for the ion source device. Background technique [0002] Hiaroka proposed "Probe Electrospray Ionization (PESI)", in which a certain voltage is applied to the tip of a conductive probe that has adsorbed a sample solution to achieve ionization of sample molecules. Various solid substrates can be used to prepare probes, including paper, toothpicks, surface-modified glass rods, copper, tungsten, stainless steel, etc. [0003] Fu et al. analyzed the inner and outer epidermal cells of onion cells by using porous metal probes obtained by corroding copper (Cu) wires with HCl and MALDI-TOF. Based on this method, they successfully analyzed the metabolites in onion cells at the single cell level. Identification analysis. Gong and other metabolites. Yu et al. used functionaliz...

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Problems solved by technology

However, in the process of sample ionization, in addition to adding auxiliary solvents to help sample desorption, there are no other auxiliary means to assist sample desorption and focus transmission to the mass spectrometer detector, resulting in low ionization efficiency and ion transmission efficiency, and the existing functions The enrichment ability of chemical probes is limited (mostly fructose and some lipids), which limits its detection range

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