A nanocomposite anti-adhesion hernia repair sheet and its preparation method
A nano-composite, anti-adhesion technology, applied in the direction of prosthesis, surgery, coating, etc., can solve the problems of short anti-adhesion retention time, poor human safety, poor anti-adhesion performance, etc., and achieve low cost and improved performance. Excellent strength and anti-blocking performance, anti-blocking performance and mechanical properties
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Embodiment 1～108
[0050] A preparation method of a nanocomposite anti-adhesion hernia repair sheet, the steps are as follows:
[0051] (1) Medical-grade polypropylene monofilament is warp-knitted to obtain a polypropylene warp-knitted mesh patch, wherein the diameter of the polypropylene monofilament is 0.152mm, and the warp-knitted drawing density is 10 courses / cm, and the width is 1m. The organizational structure of the acrylic warp-knitted mesh patch is shown in Table 1, and the thickness is 0.5524-0.8169mm;
[0052] (2) Carry out heat-setting treatment to polypropylene warp-knitted mesh patch again, and the conditions of heat-setting treatment are shown in Table 1;
[0053] (3) Collagen and PEO are mixed and then dissolved in a mixed solvent of hexafluoroisopropanol and acetic acid and magnetically stirred at a speed of 400r / min for 24h to prepare an electrospinning solution, wherein the mass ratio of collagen to PEO is 70:30, The volume ratio of hexafluoroisopropanol to acetic acid is 1:1...
Embodiment 110
[0081] A preparation method of a nanocomposite anti-adhesion hernia repair sheet, the steps are as follows:
[0082] (1) Warp knitting the medical-grade polypropylene monofilament to obtain a polypropylene warp-knitted mesh patch, wherein the diameter of the polypropylene monofilament is 0.150mm, the warp-knitting pulling density is 12 courses / cm, and the width is 0.8m. The thickness of the polypropylene warp-knitted mesh patch is 0.60mm, and the polypropylene warp-knitted mesh patch is a warp satin weave. The weaving let-off amount: GB1 is 2800mm / rack, GB2 is 2400mm / rack, and its mesh shape is rhombus;
[0083] (2) carry out heat setting treatment to polypropylene warp knitted mesh patch again, the condition of heat setting treatment is identical with embodiment 5;
[0084] (3) After mixing the collagen and PEO, dissolve it in a mixed solvent of hexafluoroisopropanol and acetic acid and magnetically stir it at a speed of 400r / min for 24h to prepare an electrospinning solution...
Embodiment 111
[0090] A preparation method of a nanocomposite anti-adhesion hernia repair sheet, the steps are as follows:
[0091] (1) Warp knitting the medical-grade polypropylene monofilament to obtain a polypropylene warp-knitted mesh patch, wherein the diameter of the polypropylene monofilament is 0.147mm, the warp-knitting pulling density is 12 rows / cm, and the width is 0.5m. The thickness of the polypropylene warp-knitted mesh patch is 0.70mm. The warp-knitted mesh patch is a variable flat weave. The weaving let-off amount: GB1 is 2940mm / rack, GB2 is 2700mm / rack, and its mesh shape is round;
[0092] (2) carry out heat setting treatment to polypropylene warp knitted mesh patch again, the condition of heat setting treatment is identical with embodiment 20;
[0093] (3) After mixing collagen and PEO, dissolve it in a mixed solvent of hexafluoroisopropanol and acetic acid and magnetically stir at a speed of 400r / min for 24h to prepare an electrospinning solution, wherein the mass ratio o...
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