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Injectable type gelatin microsphere-based gel hemostatic material with negative charges as well as preparation method and application of hemostatic material

A hemostatic material and injection-type technology, which is applied in the field of biomedical materials, can solve the problems of poor adhesion, weak adhesion ability, inability to apply intracavity and deep wound hemostasis, etc., and achieve the effect of reducing secondary injuries and reducing blood flow

Inactive Publication Date: 2019-03-22
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the single alginate hemostatic material has poor adhesion and needs other dressings to fix it when used
Fibrin glue hemostatic materials, such as fibrin glue foam, is a spray that has a good effect on surface wound hemostasis, but related studies have shown that due to its poor dispersion and weak adhesion, it is not suitable for Intraluminal hemostatic effect is not ideal
Gelatin-based hemostatic materials have strong hydrophilicity. After absorbing water, they expand and compress damaged blood vessels to achieve hemostasis. At the same time, gelatin can also aggregate serum proteins and platelets and activate platelets to release coagulation factors. Most of the products currently used and clinically Is a gelatin hemostatic sponge (such as: and ), this type of hemostatic material is suitable for hemostasis of open wounds during surgery and sealing of anti-seepage fluid after surgery, but cannot be used for hemostasis of intracavitary and deep wounds
[0005] Due to the current hemostatic materials are either poor in biocompatibility and biodegradability, or the hemostatic effect is not ideal when applied in cavity and deep wound

Method used

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  • Injectable type gelatin microsphere-based gel hemostatic material with negative charges as well as preparation method and application of hemostatic material
  • Injectable type gelatin microsphere-based gel hemostatic material with negative charges as well as preparation method and application of hemostatic material
  • Injectable type gelatin microsphere-based gel hemostatic material with negative charges as well as preparation method and application of hemostatic material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Preparation of hemostatic material of the present invention

[0038] 1. Preparation method

[0039] The gelatin microspheres were prepared by the water-oil emulsification method. Add 300 mL of liquid paraffin and 9 mL of emulsifier Span-80 (Span-80) into a round-bottomed three-necked flask and heat it to 45°C. After mechanically stirring, slowly add 10 mL of Type B gelatin solution (10wt%), and mechanically stir at 1000 rpm for 15 minutes After obtaining the emulsion. Subsequently, the entire system was put into ice water for 15 minutes in an ice bath, and then 3 mL of 2.5% glutaraldehyde was added for cross-linking for 2 hours. After cross-linking, an appropriate amount of ethanol was added for dehydration and the gelatin microspheres in the emulsion were precipitated. The emulsion is filtered, and then washed alternately with acetone and isopropanol several times to remove liquid paraffin and unreacted glutaraldehyde, and dried at room temperature to obtain typ...

Embodiment 2

[0046] Example 2 Preparation of the hemostatic material of the present invention

[0047] 1. Preparation method

[0048] The gelatin microspheres were prepared by the water-oil emulsification method. Add 300 mL of liquid paraffin and 9 mL of emulsifier Span-80 into a round-bottomed three-necked flask and heat to 45° C., mechanically stir evenly, slowly add 10 mL of Type B gelatin solution (10 wt%), and mechanically stir at 300 rpm for 15 minutes to obtain an emulsion. Subsequently, the entire system was put into ice water for 15 minutes in an ice bath, and then 3 mL of 2.5% glutaraldehyde was added for cross-linking for 2 hours. After cross-linking, an appropriate amount of ethanol was added for dehydration and the gelatin microspheres in the emulsion were precipitated. The emulsion is filtered, and then washed alternately with acetone and isopropanol several times to remove liquid paraffin and unreacted glutaraldehyde, and dried at room temperature to obtain type B gelatin micros...

Embodiment 3

[0055] Example 3 Preparation of the hemostatic material of the present invention

[0056] 1. Preparation method

[0057] The gelatin microspheres were prepared by the water-oil emulsification method. Add 300 mL of liquid paraffin and 9 mL of emulsifier Span-80 into a round-bottomed three-necked flask and heat to 45°C. After mechanically stirring, 10 mL of Type A gelatin solution (10 wt%) is slowly added, and the emulsion is obtained after mechanical stirring at 1000 rpm for 15 minutes. Subsequently, the entire system was put into ice water for 15 minutes in an ice bath, and then 3 mL of 2.5% glutaraldehyde was added for cross-linking for 2 hours. After the cross-linking, an appropriate amount of ethanol was added for dehydration and the gelatin microspheres in the emulsion were precipitated. The emulsion is filtered, and then alternately washed with acetone and isopropanol several times to remove liquid paraffin and unreacted glutaraldehyde, and dried at room temperature to obtain...

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Abstract

The invention discloses an injectable type gelatin microsphere-based gel hemostatic material with negative charges. The gelatin microsphere-based gel hemostatic material is prepared into gelatin microsphere-based gel by enabling gelatin microspheres to generate hydration with water, the gelatin microsphere-based gel is endowed with injectability, and injection can be performed by a common injector; the requirement on accurate and rapid delivery of hemostatic gel to a point needing hemostasis is satisfied at a deep bleeding point and when intracavitary bleeding happens; meanwhile, gelatin has the characteristics of absorbing water to expand and being absorbable and degradable of gelatin, thus the injected hemostatic gel absorbs blood to expand and compress blood vessels at a wound, the reduction of blood flow volume is realized to stop bleeding, and the hemostatic gel does not require to be taken out, thereby reducing secondary damage to patients.

Description

Technical field [0001] The invention belongs to the field of biomedical materials, and specifically relates to a negatively charged injectable gelatin microsphere-based gel hemostatic material used for deep and intracavitary bleeding in clinical operations, and a preparation method and application thereof. Background technique [0002] During the surgical operation, the bleeding site of the patient can be stopped quickly and effectively, which is conducive to shorten the operation time and promote the smooth operation of the operation to increase the success rate of the operation, thereby saving more lives. At present, materials that can be used to stop bleeding in trauma mainly include inorganic hemostatic materials and organic hemostatic materials. [0003] Inorganic hemostatic materials mainly include zeolite and kaolin. Zeolite has good hemostatic properties, can significantly shorten the time of hemostasis and reduce the amount of bleeding. In the process of hemostasis, zeol...

Claims

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Application Information

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IPC IPC(8): A61L24/00A61L24/10
CPCA61L24/001A61L24/0031A61L24/0042A61L24/104A61L2400/04A61L2400/06
Inventor 李鸿李林杜艳吕国玉严永刚杨爱萍刘铁龙
Owner SICHUAN UNIV
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