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Novel application of cordyceps sobolifera sporocarps

A technology of cicada flower seed and entity, applied in the field of cicada flower fruit body, which can solve the problems of rejection psychology, liver and kidney function damage, and reduced patient tolerance.

Inactive Publication Date: 2019-03-26
ZHEJIANG BIOASIA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In terms of treatment, several western medicines commonly used in clinic have obvious adverse reactions, such as common nausea, vomiting, diarrhea, etc., which can cause serious complications such as liver and kidney function damage, and the patient's tolerance gradually decreases, and then rejection of drug treatment

Method used

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  • Novel application of cordyceps sobolifera sporocarps
  • Novel application of cordyceps sobolifera sporocarps
  • Novel application of cordyceps sobolifera sporocarps

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 The effect of cicadae fruiting bodies on reducing uric acid

[0025] 1.1 Model establishment: Acute gout model mice were intragastrically administered corresponding doses of medicinal liquid for 7 days in each administration group, and 30 minutes before the last administration, the model and each administration group were intraperitoneally injected with hypoxanthine and subcutaneously injected with potassium oxonate to establish the model. 1.5 hours after the last administration, blood was collected from the animals to detect uric acid.

[0026] The rat model of chronic gout and each administration group were given intragastric administration of adenine and ethambutol hydrochloride every day to establish the model, and at the same time intragastric administration of corresponding doses of medicinal solution for 21 days. 1.5 hours after the last administration, blood was collected to detect uric acid.

[0027] 1.2 Grouping method: Acute and chronic gout experi...

Embodiment 2

[0043] Example 2 The effect of cicadae fruiting body on liver and kidney in chronic gout

[0044] 2.1 Model establishment: The rat model of chronic gout and each administration group were administered intragastrically with adenine and ethambutol hydrochloride every day to establish the model, and at the same time, the corresponding dosage of medicinal liquid was intragastrically administered for 21 days. 1.5 hours after the last administration, the left kidney and part of the right kidney were fixed for urate crystal staining and HE staining respectively.

[0045] 2.2 Grouping method: Chronic gout experiments were randomly divided into blank control group, model control group, positive control group, cicada pollen low, medium and high dose groups, 10 animals / group, a total of 6 groups.

[0046] 2.3 Dosage design: The daily recommended dosage of cicadae fruiting bodies for human body is 0.017g / kg body weight, and the clinical dosage for human body of the positive control drug A...

Embodiment 3

[0057] Get 10 g of cicadae fruiting body powder, add appropriate auxiliary materials for injections (including freeze-dried powder injections and sterile subpackaged dry powder injections), and prepare injections according to the injection (including freeze-dried powder injections and sterile subpackaged dry powder injections) process.

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PUM

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Abstract

The invention relates to an application of artificial cordyceps sobolifera sporocarps in preparing a drug for treating gout or reducing uric acid. The artificial cordyceps sobolifera sporocarps product has a certain improving effect to acute and chronic gout. An acute and chronic gout molding experiment verifies that the artificial cordyceps sobolifera sporocarps can reduce the level of serum uricacid of acute and chronic gout, improves the diseases such as degeneration and necrosis of kidney tubules, urate deposition of kidney tubules, expansion of kidney tubules, inflammatory cell infiltration of kidney tubules and cellular cast of kidney tubules induced by chronic gout to a certain extent, and can improve the liver index at the same time. The artificial cordyceps sobolifera sporocarpscan be used for preparing the drug for treating gout or reducing uric acid. The invention explores a novel path for applying the artificial cordyceps sobolifera and has curative meaning for patients with gout and hypeluricemia.

Description

technical field [0001] The invention relates to a new application of the cicadae fruiting body, in particular to a new application of the cicadae flowering fruiting body in treating gout and lowering uric acid. Background technique [0002] When the metabolism of purine substances in the human body is disturbed or the excretion of uric acid is obstructed, hyperuricemia will be caused. When the blood uric acid concentration in the human body is too high, the uric acid in the body will be deposited in the joints, cartilage and kidneys in the form of sodium salt. Inflammation of foreign body in tissues is caused, which is called gout. Now, due to changes in people's living and eating habits, the incidence of gout is gradually increasing. Repeated morbidity, joint inflammation, swelling, deformation, etc. have brought great misery to the patient. In terms of treatment, several western medicines commonly used in clinic have obvious adverse reactions, such as common nausea, vomi...

Claims

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Application Information

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IPC IPC(8): A61K36/068A61P19/06A61P13/12A61P1/16
CPCA61K35/64A61K36/068A61K2236/331A61K2236/333A61K2236/55A61K36/066A61K35/63A61P1/16A61P13/12A61P19/06
Inventor 闫文娟刘艳菊孙长胜
Owner ZHEJIANG BIOASIA PHARMA CO LTD
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