Antigen epitope polypeptide cd44-p3 based on prostate cancer stem cell marker cd44 and its application

A CD44-P3, antigen epitope technology, applied in the direction of CD44, receptor/cell surface antigen/cell surface determinant, application, etc., can solve the problem of limited killing effect, low specificity of anti-tumor treatment technology, easy tumor recurrence, etc. problem, to reduce recurrence, enhance clear effect, and enhance suppression effect
CN109608536BInactive Publication Date: 2020-09-15深圳市龙华区人民医院
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
深圳市龙华区人民医院
Publication Date
2020-09-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides an antigen epitope polypeptide CD44-P3 based on a prostate cancer stem cell marker CD44 and application thereof, and relates to the technical field of biological medicine engineering. According to the antigen epitope polypeptide CD44-P3 based on the prostate cancer stem cell marker CD44 and the application thereof provided by the invention, an antigen epitope polypeptide isdesigned and synthesized by adopting bioinformatics means on basis of the prostate cancer stem cell surface-marker CD44. The synthesized antigen epitope polypeptide is capable of specifically activating cytotoxic T lymphocytes, and has good killing effect; and thus, the antigen epitope polypeptide can be used for developing therapeutic peptide vaccines targeting prostate cancer stem cells, therebyproviding new technical schemes for precise immunotherapy of malignant prostate cancer. In addition, specific targeting on prostate cancer stem cells is also enabled so as to fundamentally reduce recurrence of prostate cancer.
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Description

technical field

[0001] The invention relates to the technical field of biomedical engineering, in particular to an epitope polypeptide CD44-P3 based on the prostate cancer stem cell marker CD44 and its application. Background technique

[0002] At present, the morbidity and mortality of prostate cancer are increasing year by year, and it has become the number one killer that seriously threatens human health. Although the surgical treatment, chemotherapy, radiotherapy and molecular targeted therapy of prostate cancer have made new progress, the effective treatment of prostate cancer is still a key problem to be solved.

[0003] In recent years, with the continuous revelation of the molecular mechanism and immune mechanism of prostate cancer, more and more attention has been paid to the specific immunotherapy of prostate cancer, and the key to tumor immunotherapy is to obtain an ideal tumor antigen. With the rapid development of immunological theoretical methods and molecular...

Claims

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