Detection method of flavoring additive in special medical use formula food

A formula food and detection method technology, applied in the direction of measuring devices, scientific instruments, material separation, etc., can solve the problems of weak mutagenic activity, cell death, dyspnea, etc., achieve less interference, simplify pretreatment steps, and high recovery rate Effect

Active Publication Date: 2019-04-16
ZHOUSHAN INST FOR FOOD & DRUG CONTROL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the use of vanillin and other additives in food for special medical needs is essential, and the safety of vanillin and other additives is still controversial at home and abroad. The use of large doses of vanillin and other additives has greater harm to the human body. Excessive intake can lead to headaches, nausea, vomiting, dyspnea, and even liver and kidney damage. At the same time, maltol has weak mutagenic activity and toxic effects of inducing cell death, etc.

Method used

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  • Detection method of flavoring additive in special medical use formula food
  • Detection method of flavoring additive in special medical use formula food
  • Detection method of flavoring additive in special medical use formula food

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Embodiment Construction

[0027] In order to illustrate the content of the present invention more clearly, specific examples are used to illustrate the following, and the specific examples do not limit the scope of the content of the present invention.

[0028] Instruments and reagents

[0029] Agilent1260LC liquid chromatograph (Agilent Corporation of the United States), configuration diode array detector (DAD); Chromatographic column: Poroshell 120SB-Aq, (4.6 × 100mm, 2.7μm); UV-2700 ultraviolet-visible spectrophotometer (Shimadzu Enterprise Management (China) Co., Ltd.) BS-124S ​​1 / 100,000 electronic balance (Beijing Sartorius Instrument System Co., Ltd.); FC204 1 / 100,000 electronic balance (Shanghai Precision Scientific Instrument Co., Ltd.); H20-I-2-TOC -T ultrapure water device (Sartorius Scientific Instrument Co., Ltd.); AllegraX-30R centrifuge (Beckman Coulter Co., Ltd.); MS3 vortex mixer (Germany IKA company); SPE column: (500mg / 6ml), (500mg / 6ml), Welchrom P-WAX, Captive EMR-Lipid small co...

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Abstract

The detection method of a flavoring additive in special medical use formula food is disclosed. Through a through-type solid-phase extraction technology, a suitable extraction method Captive EMR-Lipidpurification column is selected to purify a sample, activation and balance are not needed before sample loading, a sample liquid is directly loaded to a SPE column to adsorb the carbon chain of C5 andabove in the lipid of an FSMA sample so as to remove lipid and protein interferents, and achieve the purpose of purifying the 11 kinds of target flavoring additives. A small column can keep a filterelement without a solvent, gravity outflow can be realized, a sample pre-processing step is simplified, pre-treatment time is shortened and the interference of a sample impurity peak is reduced so asto significantly improve the reliability and the practicability of the method. Purification is performed by a solid-phase extraction SPE form and through Captive EMR-Lipid (enhanced lipid removal filtration column) and a high performance liquid chromatograph is used to detect. The method has the advantages of a high recovery rate, simple and rapid performance and the like and the daily requirementof the limited control of flavoring compounds in special medical food can be satisfied.

Description

technical field [0001] The invention relates to the technical field of food additive detection, in particular to a method for detecting flavor additives in formula food for special medical purposes. Background technique [0002] Formula food for special medical purposes (FSMA, hereinafter referred to as food for special medical purpose) is a formula food specially processed and formulated to meet the special needs of nutrients or diet for people with restricted eating, digestive and absorption disorders, metabolic disorders or specific disease states. The main ingredients are biologically active ingredients such as protein, fat, carbohydrates, and vitamins. It is an emerging food industry in China. However, the use of vanillin and other additives in food for special medical treatment is essential. The safety of vanillin and other additives is still controversial at home and abroad. The use of large doses of vanillin and other additives has greater harm to the human body. Ex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/14
CPCG01N30/02G01N30/06G01N30/14G01N2030/062G01N2030/143
Inventor 吴纤愫
Owner ZHOUSHAN INST FOR FOOD & DRUG CONTROL
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